HOME >> BIOLOGY >> NEWS
'Conversation stoppers' fight deadly bacterial infections

SAN FRANCISCO, Sept. 10 -- Bacterial infections are becoming more deadly worldwide due to increased resistance to antibiotics. Now, chemists at the University of Wisconsin-Madison have developed a powerful strategy to fight these deadly infections: Instead of killing the bacteria directly, the scientists designed a group of compounds that can block the chemical signals that the bacteria use to communicate in an effort to stop their spread.

These compounds, small organic molecules that they call 'conversation stoppers,' could help deliver a powerful one-two punch to knock out deadly infections when combined with the killing power of antibiotics, the scientists say. In addition, these 'conversation stoppers' do not target bacterial growth, so the potential for the development of bacterial resistance is minimized. This research, which is funded by the National Institutes of Health, could lead to new drugs to fight infections, was described today at the 232nd national meeting of the American Chemical Society.

"There is an urgent, global need for new antibacterial therapies," says study leader Helen Blackwell, Ph.D., an assistant professor of chemistry at the University. "The ability to interfere with bacterial virulence by intercepting bacterial communication networks represents a new therapeutic approach and is clinically timely."

Bacteria use chemical signals to initiate the majority of human infections. When these signals reach a certain threshold (in a process known as quorum sensing), pathogenic bacteria will change their mode of growth and produce virulence factors that lead to infection. These chemical signals also trigger the bacteria to produce slimy biofilms that cloak the bacteria and make the colony physically resistant to antibiotics.

Attempts to block bacterial quorum sensing are being conducted by a growing number of research groups. Many of these studies have focused on a group of small molecules called N-acy
'"/>


10-Sep-2006


Page: 1 2

Related biology news :

1. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
2. CRESIB coordinates an international consortium to fight malaria caused by Plasmodium vivax
3. Tumor painting revolutionizes fight against cancer
4. Aphids make chemical weapons to fight off killer ladybirds
5. Neuroblastoma expert reviews progress and challenges in fighting difficult pediatric cancer
6. Researchers develop buckyballs to fight allergy
7. CSIRO scientists join fight to save Tassie devil
8. Scientists develop new drugs to fight colon and breast cancer more effectively
9. Leading the fight against food poisoning
10. Plant pathologists fighting global threat to wheat supply
11. Keeping the immune system from starting a food fight

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/28/2017)... BARCELONA , Spanien, 27. Februar 2017 /PRNewswire/ ... durch Iris-Scan, wird seine erstklassige biometrische Lösung ... Snapdragon™ 835 mit X16 LTE auf dem ... 2. März) am Qualcomm-Stand in Halle 3, ... 835-Prozessor beinhaltet die Sicherheitsplattform Qualcomm Haven™ – ...
(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader of ... elite iris biometric solution on the latest Qualcomm® ... at Mobile World Congress 2017 (February 27 ... in Hall 3, Stand 3E10. ... Haven™ security platform—a combination of hardware, software ...
(Date:2/21/2017)... -- Der weltweite Biobanking-Sektor wird bis zum ... mit mehr als 50 Vertretern aus verschiedenen Branchen wurde aber ... diese Prognose zu realisieren. ... Zu den Schwierigkeiten für ... für die Biobank, die Implementierung Zeit sparender Technologien, ein ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... WASHINGTON , March 28, 2017 /PRNewswire/ ... launch single-cell sequencing during the American Association for Cancer ... Convention Center in Washington, D.C. , ... differential gene expression of thousands of cells at the ... Experts on-hand at AACR to discuss ...
(Date:3/28/2017)... 28, 2017 Biostage, Inc. (Nasdaq: ... bioengineered organ implants to treat cancers and other life-threatening ... that Jim McGorry, CEO of Biostage, will ... panel at the MassBio 2017 Annual Meeting ... in Cambrige, Massachussetts. The 3D Printing and BioEngineering ...
(Date:3/28/2017)... March 28, 2017 /PRNewswire/ -RepliCel Life Sciences Inc. (OTCQB: REPCF) ... report compelling safety and clinical data from its phase 1/2 ... collagen-expressing, hair follicle-derived fibroblasts (RCT-01) as a treatment for Achilles ... ... complete safety profile at 6 months and showed no serious ...
(Date:3/27/2017)... Cousins Properties (NYSE: CUZ ) announced today that ... a 10-year, approximately 125,000 square-foot lease at Corporate Center, a ... Westshore submarket of Tampa, FL. ... Center for their new location in Tampa ... officer of Cousins Properties. "Amgen is a cutting-edge global company ...
Breaking Biology Technology:
Cached News: