HOME >> BIOLOGY >> NEWS
'Conversation stoppers' fight deadly bacterial infections

lated L-homoserine lactones (AHLs), which are key signaling molecules used by Gram-negative bacteria.

But discovery of these molecules has been a relatively slow process until now. Blackwell and her associates have found that the use of 'microwave-assisted chemistry,' a novel laboratory technique for heating chemical reactions using microwaves, can dramatically accelerate the synthesis of AHL analogs that can either block or stimulate bacterial communication.

"Using microwave heating and combinatorial techniques to generate libraries of molecules, we can now produce and test in one day a group of compounds that previously would have taken a month to study using conventional techniques," Blackwell says.

So far, the researchers have identified at least two compounds that show particular promise at blocking biofilm formation in Pseudomonas aeruginosa, a bacterium that is a common cause of death in people with cystic fibrosis, AIDS and severe burns. In collaborative research with Fred Ausubel, Ph.D., a molecular biologist at Massachusetts General Hospital in Boston, Blackwell and her colleagues demonstrated that several of these compounds can extend the lives of worms infected with P. aeruginosa.

Recently, Blackwell designed 'conversation stoppers' that are specific to one bacterial strain and not others, allowing more efficient, selective attack on specific bacterial strains. This selectivity can help avoid disrupting beneficial bacteria, such as those in the gut that aid digestion, she says.

Some 'conversation stoppers' also hold promise for fighting crop diseases, biofilm formation on medical implants and catheters, and even bioterror agents. More studies are needed, says Blackwell, adding that her compounds haven't been tested in humans or plants but says that those tests are anticipated.


'"/>


10-Sep-2006


Page: 1 2

Related biology news :

1. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
2. CRESIB coordinates an international consortium to fight malaria caused by Plasmodium vivax
3. Tumor painting revolutionizes fight against cancer
4. Aphids make chemical weapons to fight off killer ladybirds
5. Neuroblastoma expert reviews progress and challenges in fighting difficult pediatric cancer
6. Researchers develop buckyballs to fight allergy
7. CSIRO scientists join fight to save Tassie devil
8. Scientists develop new drugs to fight colon and breast cancer more effectively
9. Leading the fight against food poisoning
10. Plant pathologists fighting global threat to wheat supply
11. Keeping the immune system from starting a food fight

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 02, 2020 , ... ... announced a publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler ... (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions ... data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... hospitalized patients with severe COVID-19. This is the first study of an XPO1 ...
(Date:6/23/2020)... BOSTON (PRWEB) , ... June 23, 2020 , ... In ... feature interview with Dr. James L. Sherley, M.D., Ph.D., founder and director ... after the company announced on June 16 that starting July 5 it ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 26, 2020 , ... ... security solutions providers, today announced its strong opposition to the recently introduced bicameral ... impose a blanket ban on most federal use of nearly all biometric and ...
(Date:6/23/2020)... Ore. (PRWEB) , ... June 23, 2020 , ... ... of innovative CNS therapies, today announced that it has filed an Investigational New ... a Phase 2b clinical trial of its lead drug candidate NBTX-001 in patients ...
(Date:6/11/2020)... ... ... Reducing carbon emissions has been and will continue to be a major topic of ... reduce CO2 is something we can’t avoid. , To protect the environment, oil ... are created from recycled cooking oil or crops. Unfortunately, these sources are not sustainable. ...
(Date:5/28/2020)... , ... May 28, 2020 , ... ... today announced the release of Genedata Screener ® 17.0, the latest version ... data from all in-vitro screening assay technologies. Genedata will host a webinar on ...
Breaking Biology Technology:
Cached News: