HOME >> BIOLOGY >> NEWS
'Cookbook recipes' would cure disease with nontoxic DNA delivery systems

CHAMPAIGN, Ill. -- Scientists studying the structure and interaction of negatively charged lipids and DNA molecules have created a "cookbook" for a class of nontoxic DNA delivery systems that will assist doctors and clinicians in the safe and effective delivery of genetic medicine.

As reported in the Aug. 9 issue of the Proceedings of the National Academy of Sciences, researchers have now performed a careful, comprehensive study to see how negatively charged lipids stick to negatively charged DNA and self-organize into structures.

"Many research groups have made concoctions with ingredients in different proportions and then assessed their effectiveness in gene delivery, but this is hard and requires a lot of intuition," said Gerard Wong, a professor of materials science and engineering, physics, and bioengineering at the University of Illinois at Urbana-Champaign, and corresponding author of the paper.

"By understanding some of the physics, we now have recipes for assembling delivery systems with different structures, which can have intrinsically different, controllable DNA delivery efficiencies," Wong said. "We found that the same family of structures are generated for many different ions."

Gene therapy is one of the most promising strategies for developing cures for many hereditary and acquired diseases. Protocols have been approved for treating cancer, cystic fibrosis and neuromuscular disorders, for example, but delivering DNA to the proper location and getting the right amount of DNA expression without killing innocent cells has become the Achilles' heel in DNA delivery.

Positively charged (cationic) synthetic molecules will readily bond to negatively charged DNA molecules and have been used for DNA delivery, but these cationic molecules are often toxic to cells, Wong said. An alternative is to use naturally occurring negatively charged (anionic) lipids that won't harm cells.

"The problem then becomes: 'How do you
'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
10-Aug-2005


Page: 1 2

Related biology news :

1. AAAS analysis finds Congress would add billions to FY 2008 R&D investment
2. The bee that would be queen
3. Smallpox outbreak: How long would it take for vaccines to protect people? Would it work?
4. 2-protein team would be lost without each other
5. Healthy coastal wetlands would adapt to rising oceans
6. Is it ethical for scientists to do research abroad that would be forbidden at home?
7. Designer babies - what would you do for a healthy baby?
8. New discovery: If it werent for this enzyme, decomposing pesticide would take millennia
9. Proposal would allow wild animals to roam North America
10. Passage of Marin County GMO ban would encourage widespread use of harsh pesticides
11. Passage of GMO ban in San Luis Obispo would encourage use of harsh pesticides

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... Hong Kong (PRWEB) , ... May 22, 2017 ... ... the third year in a row in the Aragon Research Globe™ for Corporate ... that align with industry direction and market demand, and effectively perform against those ...
(Date:5/23/2017)... ... ... Vortex Biosciences , provider of circulating tumor cell (CTC) capture systems, ... Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. The peer ... Dr. Matthew Rettig at the University of California, Los Angeles. The publication describes the ...
(Date:5/23/2017)... ... May 23, 2017 , ... Kathy Goin is joining ... Operations. She brings years of expertise in establishing and leading clinical operations at ... a licensed occupational therapist, through a variety of leadership roles in Clinical Operations, ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Cambridge Semantics ... splash at this year’s Bio-IT World Conference and Expo in Boston May ... Lake® 4.0 solution. The Anzo Smart Data Lake is also a finalist for ...
Breaking Biology Technology:
Cached News: