HOME >> BIOLOGY >> NEWS
Cooling analgesia harnessed to relieve chronic pain

By experimentally activating a special protein involved in mediating sensations of coolness, researchers have made a breakthrough in understanding how the body's nervous system can be stimulated to relieve chronic pain. The findings are reported by a team led by Susan Fleetwood-Walker and Rory Mitchell of University of Edinburgh and appear in the August 22nd issue of the journal Current Biology, published by Cell Press.

Ancient Greek physicians knew of the benefits of cooling to relieve pain, and many traditional remedies use mint oil for relieving pain, but it is only now, in the 21st century, that a mechanism for such analgesic effects has been identified.

In their new work, the researchers looked for ways to relieve chronic pain in rats, and they found that certain cooling chemicals, either injected or simply applied in small doses to the skin, have a dramatic natural painkilling effect. The researchers showed that the analgesic effect occurs through activation of a recently identified protein, called TRPM8, that is expressed in nerve cells in the skin and responds to both cool temperatures and cooling chemicals, such as the active ingredients in mint.

TRPM8 belongs to an interesting class of proteins whose members mediate the sensation of diverse stimuli, including taste, temperature, and touch.

Approaches using cooling compounds that activate the TRPM8 protein could be used for chronic pain patients--for example, in treating neuropathic pain and arthritis in cases where conventional painkillers have little effect or are of limited use as a result of side effects. Such therapies would make use of the body's own capacity to suppress pain. The discovery of a novel biological mechanism by which cooling analgesia works therefore has great potential for relieving the suffering of millions of chronic pain patients.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
21-Aug-2006


Page: 1

Related biology news :

1. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
2. Brain enzyme treatment relieves memory lapse in Alzheimers mice
3. New data suggest pramipexole relieves symptoms of Restless Legs Syndrome (RLS) and is well-tolerated
4. Pain reliever may help treat life-threatening childhood disease
5. NIAID supports research into etiology of fungal-induced inflammation in chronic sinusitis
6. NIH awards VBI, Mayo Clinic $2.4M to study chronic rhinosinusitis
7. Scientists identify new strategy for preventing acute and chronic brain disease
8. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
9. Study shows food preparation may play a bigger role in chronic disease than was previously thought
10. How do the rules of immunity change during chronic infections?
11. The metabolic response to colitis varies depending upon whether inflammation is chronic or acute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: