HOME >> BIOLOGY >> NEWS
Coordinating DNA and histone methylation

In the November 15th issue of G&D, Dr. Sriharsa Pradhan (New England Biolabs) and colleagues demonstrate that the DNA methyltransferase, DNMT1, and the histone methyltransferase, G9a, interact to coordinate DNA and histone methylation during DNA replication. The researchers found that the two proteins co-localize and positively influence each other's catalytic activities. Furthermore, siRNA-mediated knockdown of DNMT1 not only impairs DNA methylation as expected, but also impairs histone H3K9 methylation. This work suggests that DNMT1 and G9a may cooperate to maintain epigenetic marks during cell division, and, as Dr. Pradhan points out, now that this interaction has been uncovered "we go to work on uncovering the coupling mechanism."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
2-Nov-2006


Page: 1

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Linking DNA and histone methylation
3. The meiotic histone code
4. ASBMB Schering-Plough Award lecture to focus on histone modifications in transcription
5. In Nature paper, scientists at U.Va. health system crack part of histone code

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval ... CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be assigned a ... The company’s solutions are the first Wharton’s jelly allograft product to be recognized as ...
(Date:7/22/2020)... ... 21, 2020 , ... USDM Life Sciences , a ... a new solution to manage regulated workloads on Microsoft Azure. , Regulated biotechnology, ... complies with FDA and global regulations. USDM's new managed service for regulated workloads ...
(Date:7/10/2020)... CHICAGO (PRWEB) , ... July 09, 2020 , ... Today ... Umami Advantage, which will share insight on the “fifth taste” phenomenon that is revolutionizing ... snacks. The Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SOMERSET, N.J (PRWEB) , ... July 29, 2020 ... ... editing company, and Catalent, the leading global provider of advanced delivery technologies, development, ... products, today announced that they have entered into a strategic partnership whereby Catalent ...
(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... ... ... fast-growing provider of cloud-based software for the life sciences industry, today announced ... and presentation platform designed specifically for Medical Science Liaisons (MSLs) and other ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt ... the market and we were pleased that the IFT jury recognized that.” reFRESH™ couples ... a natural way to extend the shelf life and improve the safety of perishable ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
Breaking Biology Technology:
Cached News: