HOME >> BIOLOGY >> NEWS
Coordinating DNA and histone methylation

In the November 15th issue of G&D, Dr. Sriharsa Pradhan (New England Biolabs) and colleagues demonstrate that the DNA methyltransferase, DNMT1, and the histone methyltransferase, G9a, interact to coordinate DNA and histone methylation during DNA replication. The researchers found that the two proteins co-localize and positively influence each other's catalytic activities. Furthermore, siRNA-mediated knockdown of DNMT1 not only impairs DNA methylation as expected, but also impairs histone H3K9 methylation. This work suggests that DNMT1 and G9a may cooperate to maintain epigenetic marks during cell division, and, as Dr. Pradhan points out, now that this interaction has been uncovered "we go to work on uncovering the coupling mechanism."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
2-Nov-2006


Page: 1

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Linking DNA and histone methylation
3. The meiotic histone code
4. ASBMB Schering-Plough Award lecture to focus on histone modifications in transcription
5. In Nature paper, scientists at U.Va. health system crack part of histone code

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... OHAUS Corporation, ... the launch of its new line of Heavy-Duty Orbital Shakers today. , Eight ... and digital) for laboratory applications. These shakers are ideal for load capacities ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... long-standing innovation strategy. A website (openinnovation.pioneer.com) dedicated to connecting third-party innovators ... – trait discovery, plant breeding, enabling technologies, biologicals and digital solutions. , “DuPont ...
(Date:7/14/2017)... , ... July 14, 2017 , ... ... EMS company . Sonic Manufacturing Technologies has installed a solar system on its ... a three-year period,” the President of Sonic, Kenneth Raab stated. The company’s proud ...
(Date:7/13/2017)... Muncie, IN (PRWEB) , ... July 13, 2017 , ... ... throughout July and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie ... even try to earn spots on US teams that participate in world championships. , ...
Breaking Biology Technology:
Cached News: