HOME >> BIOLOGY >> NEWS
Cortex area thinner in youth with Alzheimer's-related gene

A part of the brain first affected by Alzheimers disease is thinner in youth with a risk gene for the disorder, a brain imaging study by researchers at the National Institute of Mental Health (NIMH), one of the National Institutes of Health (NIH), has found. A thinner entorhinal cortex, a structure in the lower middle part of the brains outer mantle, may render these youth more susceptible to degenerative changes and mental decline later in life, propose Drs. Philip Shaw, Judith Rapoport, Jay Giedd, and NIMH and McGill University colleagues. They report on how variation in the gene for apoliproprotein (ApoE), which plays a critical role in repair of brain cells, affects development of this learning and memory hub in the June, 2007 Lancet Neurology.

"People with the Alzheimers-related variant of the ApoE gene might not be able to sustain much aging-related tissue loss in the entorhinal cortex before they cross a critical threshold," explained Shaw. "But the early thinning appears to be a harmless genetic variation rather than a disease-related change, as it did not affect youths intellectual ability. Only long-term brain imaging studies of healthy aging adults will confirm whether this anatomical signature detectible in childhood predisposes for Alzheimers."

It was already known that adults destined to develop Alzheimers disease tend to have a smaller and less active entorhinal cortex. This structure is the first to shrink in volume and to develop the neurofibrillary tangles characteristic of the disorder.

Previous studies had also implicated in Alzheimers one of three versions of a gene that produces ApoE. The ApoE4 variant occurs in 10-25 percent of the general population, but in 40 percent of late-onset Alzheimers patients. The strongest genetic risk factor for the disease discovered to date, ApoE4 has been linked to altered brain activity in adults and impaired neuronal development.

Shaw and colleagues s
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
23-Apr-2007


Page: 1 2

Related biology news :

1. Cortex matures faster in youth with highest IQ
2. Study provides insight into how the brain loses plasticity of youth
3. Fear circuit flares as bipolar youth misread faces
4. Brain activity in youth may presage Alzheimers pathology
5. For young canaries learning their song, freedom in youth gives way to rules in adulthood
6. UCLA scientists uncork fountain of youth for HIV-fighting cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... Conn. and TORONTO (PRWEB) , ... May 08, ... ... growth recapitalization of Axiom Real-Time Metrics (“Axiom”), a premier provider of unified eClinical ... II and III clinical trials and observational studies. Axiom is a leading e-clinical ...
(Date:5/7/2019)... (PRWEB) , ... May 07, 2019 , ... ... world’s first on-site Legionella DNA test in the UK. , In May, Landsec ... qPCR Legionella results in 45 minutes, enabling operators to take corrective action within ...
(Date:5/2/2019)... PHILADELPHIA (PRWEB) , ... April 30, 2019 , ... ... & Nadel LLP is pleased to announce that Gunes Bender, Ph.D., a ... firm’s life sciences practice group. In his new role, Bender provides technical support ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – ...
(Date:5/2/2019)... ... , ... Boston Robotic Hair Restoration announces the most advanced ... of painful hair transplant procedures. Boston Robotic Hair Restoration offers the newest, state-of-the-art ... solution to offer a minimally invasive procedure. With the ARTAS® iX robotics, patients ...
(Date:4/25/2019)... FRANCISCO (PRWEB) , ... April 24, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced global availability ... center software providers and enterprises of all sizes to harness the power of ...
(Date:4/16/2019)... FREDERICK, Md. (PRWEB) , ... April 16, 2019 ... ... will honor Blue Sources and their project partner, the U.S. Army Center for ... Retransfer of Aquatic Biomonitor Through Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company ...
Breaking Biology Technology:
Cached News: