Counting cells in blood samples may predict cancer treatment's effectiveness

ANN ARBOR, Mich. -- Counting the amount of a type of normal cell circulating in the blood of people with cancer could predict whether a tumor progresses or responds to therapy, a new study led by the University of Michigan Comprehensive Cancer Center has found. The finding could give doctors an early indication of whether a treatment will be successful, sparing patients months of an ineffective therapy.

Researchers looked at the number of endothelial cells normal cells lining the blood vessels that were circulating in the blood of people with sarcoma. Previous studies have shown that higher levels of circulating endothelial cells are found in people with cancer compared to people who are cancer-free. In this study, researchers found patients whose cancer grew after two months of treatment had high levels of circulating endothelial cells before beginning therapy, while patients whose cancer remained stable had low levels of these cells.

"This test can be used to predict the patient's outcome and survival. In addition, there are a number of drugs available in the clinic, and it may be possible to use this test to monitor the effectiveness of a drug in an individual patient," says Laurence Baker, D.O., professor of internal medicine and pharmacology at the University of Michigan Medical School. Baker will present the study results Saturday, May 14, at the American Society of Clinical Oncology annual meeting in Orlando, Fla.

Circulating endothelial cells are the target of new anti-angiogenesis drugs, which are designed to inhibit the growth of blood vessels that feed tumors. Angiogenesis, the natural process of blood vessel formation, is believed to contribute to the growth and development of cancer cells.

In this multicenter trial, researchers took blood samples from 88 people with advanced sarcoma, a cancer of the soft tissues, and analyzed it to determine the number of endothelial cells circulating in the blood. Angiogenesis inhibito


Page: 1 2 3

Related biology news :

1. Counting heads or measuring space?
2. Is more better: Counting birds may only tell part of the story
3. Newly created cancer stem cells could aid breast cancer research
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. OHSU turns mouse into factory for human liver cells
6. UCLA scientists produce functioning neurons from human embryonic stem cells
7. UCF research links proteins, stem cells and potential Alzheimers treatment
8. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
9. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
10. How cells change the pace of their steps
11. Discredited Korean embryonic stem cells true origins revealed

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... Brilliant , the leading smart ... its products are now available for purchase in the U.S., Canada, and Puerto Rico ... and low-voltage products. In addition to being available for purchase through ADI’s Digital ...
(Date:9/3/2020)... ... September 03, 2020 , ... Litmus ... an extensive third-party assessment of the company’s security practices has been completed. The ... security regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing them to ...
(Date:8/26/2020)... ... August 24, 2020 , ... ... treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan ... Drug Discovery. , Dr. Canan previously served as Executive Director of Global Health ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... ... industries, announces it has closed on the purchase of greenfield for a new, ... TX and includes over 21 acres in the initial acquisition, with an option ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
Breaking Biology Technology:
Cached News: