HOME >> BIOLOGY >> NEWS
Creation of gene targeting earns Smithies March of Dimes honor

CHAPEL HILL--For developing an indispensable tool for genetic disease research, two scientists have been named co-recipients of this year's March of Dimes Prize in Developmental Biology, to be awarded Monday (May 16) in Washington, D.C.

Drs. Oliver Smithies, Excellence Professor of pathology and laboratory medicine at the University of North Carolina at Chapel Hill School of Medicine, and Mario R. Capecchi, Distinguished Professor of human genetics at the University of Utah, are being honored for developing gene targeting.

Their technique gives scientists around the world the ability to alter particular genes in cultured cells and transfer those targeted genes to laboratory mice. Gene targeting thus allows them to design and produce "knockout" lab mice to study how the disabled gene works.

The same technology also makes it possible to change the function of a gene "knock in" -- or restore the function of a disabled gene. Because humans share the vast majority of their genes with mice, gene-targeted mice are used to reproduce diseases that occur in humans.

The March of Dimes Prize is a cash award of $250,000 and a silver medal in the design of the Roosevelt dime, in honor of President Franklin Delano Roosevelt, who founded the March of Dimes.

"Before gene targeting, researchers could not pinpoint how a specific gene worked, which was very frustrating," said Dr. Jennifer L. Howse, president of the March of Dimes. "Dr. Capecchi and Dr. Smithies, working independently, made a technological breakthrough that completely revolutionized biomedical research and our ability to study human disease and development. We're reaping the benefits every day with advances in genetic medicine."

Gene targeting is now practiced routinely by thousands of scientists all over the world, enabling them to address the most complex and critical biological problems, including the causes and treatment of birth defects and many other disorders, such
'"/>

Contact: David Williamson
919-962-8596
University of North Carolina at Chapel Hill
11-May-2005


Page: 1 2

Related biology news :

1. Creation of an international industrial chair in life cycle assessment
2. Creation of an international research network
3. Creation of antibiotic in test tube holds promise for better antibiotics
4. Creationism is not science making the case for Darwin at UCL
5. Bulls-eye -- Programs targeting math, science teacher shortage may get boost
6. AACR Annual Meeting showcases significant developments in understanding and targeting cancers
7. Researchers find stem-cell therapy effective in targeting metastatic cancer
8. By analyzing and targeting specific germs, hospital hopes to improve pneumonia treatment
9. Pain killer fights breast cancer by targeting key enzyme
10. Oncologists could gain therapeutic advantage by targeting telomere protein
11. Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
(Date:3/20/2017)... 2017 At this year,s CeBIT Chancellor Dr. ... DERMALOG. The Chancellor came to the DERMALOG stand together with the Japanese ... CeBIT partner country. At the largest German biometrics company the two government ... and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/9/2017)... , Australia , March 9, 2017 ... data at the prestigious World Lung Imaging Workshop at ... Andreas Fouras , was invited to deliver the latest ... medicine. This globally recognised event brings together leaders at ... the latest developments in lung imaging. ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... 2017  Agriculture technology company Cool Planet has closed ... conversion to commercialize its Cool Terra and Cool Fauna ... products that are simultaneously profitable as well as sustainable ... 18 months. This latest round of funding was led ... The company,s primary product, Cool Terra, can ...
(Date:3/22/2017)... , March 22, 2017  Ascendis Pharma ... its innovative TransCon technology to address significant unmet ... results for the full year ended December 31, ... year for our company as we broadened our ... leading, integrated rare disease company with an initial ...
(Date:3/22/2017)... 22, 2017 The global chronic ... research report by Transparency Market Research (TMR). The top ... and AbbVie Inc., accounted for a share of only ... in this market are focusing aggressively on mergers, acquisitions, ... is likely to lead to market consolidation in the ...
(Date:3/22/2017)... (PRWEB) , ... March 21, 2017 , ... Premier executive ... & Life Science Search Firm by Hunt Scanlon Media. , Hunt Scanlon ... and the most widely referenced global news source in the human capital sector. , ...
Breaking Biology Technology:
Cached News: