HOME >> BIOLOGY >> NEWS
Creation of gene targeting earns Smithies March of Dimes honor

CHAPEL HILL--For developing an indispensable tool for genetic disease research, two scientists have been named co-recipients of this year's March of Dimes Prize in Developmental Biology, to be awarded Monday (May 16) in Washington, D.C.

Drs. Oliver Smithies, Excellence Professor of pathology and laboratory medicine at the University of North Carolina at Chapel Hill School of Medicine, and Mario R. Capecchi, Distinguished Professor of human genetics at the University of Utah, are being honored for developing gene targeting.

Their technique gives scientists around the world the ability to alter particular genes in cultured cells and transfer those targeted genes to laboratory mice. Gene targeting thus allows them to design and produce "knockout" lab mice to study how the disabled gene works.

The same technology also makes it possible to change the function of a gene "knock in" -- or restore the function of a disabled gene. Because humans share the vast majority of their genes with mice, gene-targeted mice are used to reproduce diseases that occur in humans.

The March of Dimes Prize is a cash award of $250,000 and a silver medal in the design of the Roosevelt dime, in honor of President Franklin Delano Roosevelt, who founded the March of Dimes.

"Before gene targeting, researchers could not pinpoint how a specific gene worked, which was very frustrating," said Dr. Jennifer L. Howse, president of the March of Dimes. "Dr. Capecchi and Dr. Smithies, working independently, made a technological breakthrough that completely revolutionized biomedical research and our ability to study human disease and development. We're reaping the benefits every day with advances in genetic medicine."

Gene targeting is now practiced routinely by thousands of scientists all over the world, enabling them to address the most complex and critical biological problems, including the causes and treatment of birth defects and many other disorders, such
'"/>

Contact: David Williamson
919-962-8596
University of North Carolina at Chapel Hill
11-May-2005


Page: 1 2

Related biology news :

1. Creation of an international industrial chair in life cycle assessment
2. Creation of an international research network
3. Creation of antibiotic in test tube holds promise for better antibiotics
4. Creationism is not science making the case for Darwin at UCL
5. Bulls-eye -- Programs targeting math, science teacher shortage may get boost
6. AACR Annual Meeting showcases significant developments in understanding and targeting cancers
7. Researchers find stem-cell therapy effective in targeting metastatic cancer
8. By analyzing and targeting specific germs, hospital hopes to improve pneumonia treatment
9. Pain killer fights breast cancer by targeting key enzyme
10. Oncologists could gain therapeutic advantage by targeting telomere protein
11. Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... , ... July 15, 2019 , ... ... science expertise exclusively for Life Sciences and Healthcare companies, announces the availability of ... advisory services and strategic direction to start-up and emerging bio-pharma companies interested in ...
(Date:7/10/2019)... FRANCISCO (PRWEB) , ... July 10, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced its role ... experience and streamline the operational efficiency of its franchisees. A key part of ...
(Date:7/5/2019)... Calif. (PRWEB) , ... July 05, 2019 , ... ... with Microsoft to bring its patented Tractus™ Platform to governments around the world. ... bring cutting edge technology and point of care solutions to operating theatres worldwide ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World Congress ... Association (NCGA) announced the winners of the Consider Corn Challenge II. Three winners ... field corn to produce biobased materials. , “Corn is a sustainable, abundant and ...
(Date:6/18/2019)... and SOMERSET, N.J. (PRWEB) , ... June 17, ... ... Biologics, today announced that they have entered into an agreement for production and ... candidates, IC-100 for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and ...
(Date:6/11/2019)... ... June 10, 2019 , ... Advancements ... an upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings for more ... educate viewers about how its technology facilitates laboratories to improve efficiency and quality ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
Breaking Biology Technology:
Cached News: