HOME >> BIOLOGY >> NEWS
Creation of gene targeting earns Smithies March of Dimes honor

CHAPEL HILL--For developing an indispensable tool for genetic disease research, two scientists have been named co-recipients of this year's March of Dimes Prize in Developmental Biology, to be awarded Monday (May 16) in Washington, D.C.

Drs. Oliver Smithies, Excellence Professor of pathology and laboratory medicine at the University of North Carolina at Chapel Hill School of Medicine, and Mario R. Capecchi, Distinguished Professor of human genetics at the University of Utah, are being honored for developing gene targeting.

Their technique gives scientists around the world the ability to alter particular genes in cultured cells and transfer those targeted genes to laboratory mice. Gene targeting thus allows them to design and produce "knockout" lab mice to study how the disabled gene works.

The same technology also makes it possible to change the function of a gene "knock in" -- or restore the function of a disabled gene. Because humans share the vast majority of their genes with mice, gene-targeted mice are used to reproduce diseases that occur in humans.

The March of Dimes Prize is a cash award of $250,000 and a silver medal in the design of the Roosevelt dime, in honor of President Franklin Delano Roosevelt, who founded the March of Dimes.

"Before gene targeting, researchers could not pinpoint how a specific gene worked, which was very frustrating," said Dr. Jennifer L. Howse, president of the March of Dimes. "Dr. Capecchi and Dr. Smithies, working independently, made a technological breakthrough that completely revolutionized biomedical research and our ability to study human disease and development. We're reaping the benefits every day with advances in genetic medicine."

Gene targeting is now practiced routinely by thousands of scientists all over the world, enabling them to address the most complex and critical biological problems, including the causes and treatment of birth defects and many other disorders, such
'"/>

Contact: David Williamson
919-962-8596
University of North Carolina at Chapel Hill
11-May-2005


Page: 1 2

Related biology news :

1. Creation of an international industrial chair in life cycle assessment
2. Creation of an international research network
3. Creation of antibiotic in test tube holds promise for better antibiotics
4. Creationism is not science making the case for Darwin at UCL
5. Bulls-eye -- Programs targeting math, science teacher shortage may get boost
6. AACR Annual Meeting showcases significant developments in understanding and targeting cancers
7. Researchers find stem-cell therapy effective in targeting metastatic cancer
8. By analyzing and targeting specific germs, hospital hopes to improve pneumonia treatment
9. Pain killer fights breast cancer by targeting key enzyme
10. Oncologists could gain therapeutic advantage by targeting telomere protein
11. Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Creation gene targeting earns Smithies March Dimes honor

(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
(Date:11/4/2014)... University School of Medicine announced today that it ... funded by the Bill & Melinda Gates Foundation. ... Gynecology and Reproductive Sciences; and Vice Chair of ... of Medicine will pursue an innovative global health ... to Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Jet-fueled electricity at room temperature 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
(Date:11/22/2014)... During his lifetime Richard L. Sharp was ... himself with great people and take risks to achieve ... marveled at his extraordinarily courageous attitude when taking on ... even with his death impending—that’s how he continued looking ... ultimately take his life. , Carrying on Sharp’s relentless ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 RURO, ... solutions provider, has released Limfinity® version 5.1.4. , ... projects of Limfinity® than ever in RURO’s 8 ... and minority framework enhancement. Limfinity® version 5.1.4 is ... above and beyond bug fixes! , Limfinity® 5.1.4 ...
(Date:11/22/2014)... 22, 2014 Respiratory therapy students ... proper management of life-like respiratory ailments using the ... . Grand Rapids-based, Michigan Instruments Inc. developers of ... of the respiratory simulation units to the pro-gram, ... Valley and Muskegon Community College are collaborating to ...
(Date:11/21/2014)... Quebec , November 21, 2014 ... como responsable comercial   Mariano Rodríguez es ...   KLOX está en marcha para comenzar ... de cura de heridas de reciente aprobación en Europa   ... "la compañía") se complace al anunciar los siguientes nombramientos: ...
Breaking Biology Technology:Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3RURO Announces Limfinity® version 5.1.4 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
Cached News: