HOME >> BIOLOGY >> NEWS
Critical pairing

How did life originate on Earth? Until now, there have only been theories to answer this question. One of the fundamental steps leading to living organisms is the development of molecules that can replicate and multiply themselves--the first genetic material. A team led by Ramanarayanan Krishnamurthy and Albert Eschenmoser at The Scripps Research Institute in La Jolla, California, is researching how this molecule might have looked.

Our own genetic material is DNA. Its backbone is made of sugar and phosphate building blocks. Like a strand of pearls, the four "letters" of the genetic code are arranged along this backbone. Two complementary strands of DNA form a double helix because the purine bases adenine (A) and guanine (G) form specific pairs with the pyrimidine bases thymine (T) and cytosine (C), attaching to each other through two or three docking sites. This type of structure could also be the basis for the first genetic material. However, it is doubtful that its backbone consisted of sugar and phosphate; it may have consisted of peptide-like building blocks. Amino acids, from which peptides are made, were already present in the "primordial soup". However, the bases may also have looked different in their primitive form.

To find the right track in searching for the origins of life, the team is trying to put together groups of potential building blocks from which primitive molecular information transmitters could have been made. The researchers have taken a pragmatic approach to their experiments. Compounds that they test do not need to fulfill specific chemical criteria; instead, they must pass their "genetic information" on to subsequent generations just as simply as the genetic molecules we know today--and their formation must have been possible under prebiotic conditions. Experiments with molecules related to the usual pyrimidine bases (pyrimidine is a six-membered aromatic ring containing four carbon and two nitrogen atoms), among others, seem
'"/>

Contact: R. Krishnamurthy
rkrishna@scripps.edu
John Wiley & Sons, Inc.
17-Nov-2006


Page: 1 2

Related biology news :

1. Critical protein prevents DNA damage from persisting through generations
2. Critical hearing gene helps send auditory messages to brain
3. Critical step traced in anthrax infection
4. Critical role in programmed cell death identified
5. Mouse study: Critical Down syndrome region isnt
6. Fish eyes could hold clue to repairing damaged retinas in humans
7. Pregnancy hormone key to repairing nerve cell damage
8. Getting on your nerves ... and repairing them
9. A silent pandemic: Industrial chemicals are impairing the brain development of children worldwide
10. Novel stem cell technology develops a new cell for repairing spinal cord injuries
11. Mice brains shrink during winter, impairing some learning and memory

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Critical pairing

(Date:10/28/2014)... of Health (NIH) announced awards to expand the ... National Center for Advancing Translational Sciences (ORDR-NCATS) collaborative ... the network, physician scientists at 22 consortia will ... clinical research and investigate new treatments for patients ... by $29 million in fiscal 2014 funding from ...
(Date:10/27/2014)... researchers have delivered a scientific one-two punch with a ... self-assemble via their sticky ends. , Collagen is the ... bone and the fibrous tissues that support cells and ... better synthetic collagen for tissue engineering and cosmetic and ... has been studying synthetic collagen for a decade, teasing ...
(Date:10/27/2014)... 27, 2014) — Recent breakthroughs may pave the ... infected by parasitic helminths. These flatworms, including tapeworms ... and blood flukes (schistosomes), infect more than 300 ... life years lost due to chronic illness and ... , professor of microbiology, immunology, and tropical medicine, ...
Breaking Biology News(10 mins):NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 2NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 3'Sticky' ends start synthetic collagen growth 2'Sticky' ends start synthetic collagen growth 3GW researcher adapting breakthrough technologies to combat parasitic worm infections 2
(Date:10/30/2014)... The severe flooding that devastated a wide swath of ... the bridges, roads and other infrastructure had been upgraded ... University of Colorado Denver. , "People need to understand ... PhD, associate professor of structural engineering at the CU ... author the study. "There is an assumption that a ...
(Date:10/27/2014)... Kalorama Information says that PCR is demonstrating ... the United States and is the ... said the FDA,s Emergency Use Authorization (EUA) to authorize the ... detection of the Ebola virus was an indication that ... the IVD industry and its biennial survey on diagnostics ...
(Date:10/27/2014)... 2014 Pressure BioSciences, Inc. (OTCQB: PBIO) ... the development and sale of high pressure-based sample ... today announced that Professor Ruedi Aebersold ... reproducible, and robust method to allow – for ... on small needle biopsy samples by mass spectrometry ...
(Date:10/25/2014)... The report “Adipic Acid Market by ... Global Trends & Forecast to 2019” report analyzes ... drivers, opportunities, and trends in different regions. , ... spread through 217 slides and in-depth TOC on ... to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers will ...
Breaking Biology Technology:CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
Cached News: