Alterations in the receptor for a known inflammatory response pathway are strongly associated with Crohn's disease and ulcerative colitis, according to a report by a consortium of American and Canadian researchers in the October 26 online Science Express.
Crohn's disease and ulcerative colitis, collectively called inflammatory bowel disease (IBD), are chronic disorders that cause abdominal pain, diarrhea and gastrointestinal bleeding and affect over one million Americans. Because IBD tends to run in families and is more frequent in certain ethnic populations, especially Ashkenazi Jews, scientists have long suspected a significant genetic component.
According to senior author Judy H. Cho, M.D., associate professor in the Departments of Medicine and Genetics at Yale School of Medicine, the team found that mutations in a receptor gene associated with the interleukin-23 (IL-23) pathway, are linked to Crohn's disease. The IL-23 pathway is known to target organ-specific inflammatory responses.
"This finding is particularly intriguing because we appear to have identified a gene variant that protects against development of IBD," said Cho, who also directs the Inflammatory Bowel Disease Center at Yale. "It causes us to think about the genetics of health as well as about the genetics of the disease. One mutation appears to offer significant protection from IBD, and will be a crucial target for drugs that might better manage Crohn's disease and ulcerative colitis."
Previous genetic studies found a link between Crohn's disease and mutations in a gene known as CARD 15, but those mutations alone did not account for all of the genetic components of the disease.
To identify additional genes associated with IBD, the international research team scanned the genome, testing more than 300,000 single nucleotide polymorphisms, or SNPs, in people with Crohn's disease. They compared results with the SNPs in a similar number of pe
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Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
26-Oct-2006