HOME >> BIOLOGY >> NEWS
Crucial progress in understanding Fragile X mental retardation protein

Researchers in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine have identified a new regulatory target for the Fragile X mental retardation protein (FMRP), laying the groundwork for possible new treatments for Fragile X syndrome(FXS), the leading inherited form of mental retardation.

The findings, published in the early online edition of the June Proceedings of the National Academy of Sciences, also have implications for autism, which shares a common physiological pathway with FXS.

Fragile X syndrome is mainly caused by a mutation in the FMR1 gene on the X chromosome, leading to the loss of FMRP, which is abundantly expressed in the brain and testes. Without this protein, brain development is hampered and nerve cells cannot communicate with each other appropriately, resulting in the reduced ability to learn and memorize. Fragile X syndrome affects about one in 4,000 males and one in 8,000 females. About 20 percent of children with FXS have autism and about five percent of autistic children have FXS.

The research team led by Yingqun Huang, M.D., assistant professor in Yale Ob/Gyn, previously found that FMRP interacts with a nuclear mRNA export protein NXF2, in the mouse brain and testes. In this study, the team used mouse neuronal cells to explore the functional characteristics of this interaction.

We found that FMRP, together with NXF2, acts to down-regulate the expression of its target, the messenger RNA that encodes NXF1, which is an essential protein needed to transport most mRNAs from the nucleus to the cytoplasm of cells, said Huang. Our findings explain why the NXF1 protein level is much lower in the hippocampal neurons involved in learning and memory than in many other cells. This may suggest that a high level of NXF1 might hinder the function of these cells.

We are one of the first two labs to show that FMRP regulates gene expression at the mRNA stability le
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
6-Jun-2007


Page: 1 2

Related biology news :

1. Crucial site for endangered frogs and birds saved
2. Crucial evolutionary link points to origins of modern cells
3. Study begins to reveal clues to the cause and progression of sepsis
4. ACMG recognizes progress made in newborn screening
5. Neuroblastoma expert reviews progress and challenges in fighting difficult pediatric cancer
6. Scripps research scientists show protein accelerates breast cancer progression in animal models
7. Inflammation is at the origin and progression of diseases such as diabetes or cancer
8. Los Alamos National Laboratory making progress in Groundwater Protection Program
9. Yin and yang -- Balance could play key role in progression of Alzheimers disease
10. Cancer scientists create human leukemia process to map how disease begins, progresses
11. Treatment-induced growth factor causes cancer progression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/14/2019)... POWAY, Calif. (PRWEB) , ... November 13, 2019 , ... ... successfully enrolled the first patients in an FDA approved clinical trial for stem ... anniversary of the formation of the company as a subsidiary of VetStem Biopharma. , ...
(Date:11/12/2019)... HAUPPAUGE, N.Y. (PRWEB) , ... November 12, 2019 ... ... made-in-the-USA germicidal ultraviolet air and water purifiers, announced today that distributors voted their ... ® and MEGATRON ® water purifiers. , The most frequent maintenance task ...
(Date:11/6/2019)... ... November 06, 2019 , ... NDA Partners Chairman ... pharmaceutical industry executive with expertise in clinical pharmacology and pharmacometrics and a widely ... data analytics, has joined the firm as an Expert Consultant. , Dr. Stanski ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... Fiberstar, Inc., a global ... industry launched a new innovative website. , After extensive research, Fiberstar ... global visitors updated ingredient usage tables by food application and video tutorials. And, ...
(Date:11/6/2019)... (PRWEB) , ... November 06, 2019 , ... Diversified ... whole pieces of fruits and vegetables per hour to improve processing. , The DTI ... of multiple tons per hour to increase juice yields by up to 50% and ...
(Date:11/5/2019)... POWAY, Calif. (PRWEB) , ... November 05, 2019 , ... Ole, a German Shepherd, was ... difficulty with stairs and jumping. Though his energy level and his willingness to play ... to veterinary surgeon Dr. Holly Mullen of VCA Emergency Animal Hospital and Referral Center ...
(Date:10/30/2019)... ... October 30, 2019 , ... While using cold plasma ... students at South Dakota School of Mines & Technology are exploring new ... healthy cells alive. , If successful, the technique would prove to be a ...
Breaking Biology Technology:
Cached News: