HOME >> BIOLOGY >> NEWS
Cytokinetics presents data on CK-1827452

South San Francisco, CA, September 19, 2005 Cytokinetics, Incorporated (Nasdaq: CYTK) announced that the company presented a scientific poster on CK-1827452, a novel small molecule activator of cardiac myosin, today at the 2005 Annual Heart Failure Society of America Meeting in Boca Raton, Florida. The moderated oral poster presentation highlighted data relating to the mechanism of action of CK-1827452 as well as its characterization in a heart failure model in animals. CK-1827452 is the first clinical drug candidate to arise from the company's cardiac myosin activator program, research that leverages Cytokinetics' expertise in cytoskeletal pharmacology and muscle contractility. CK-1827452 is currently the subject of a first-time-in-human Phase I clinical trial designed to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profile of this novel drug candidate.

The poster titled, "Direct Activation of Cardiac Myosin by CK-1827452 Improves Cardiac Function in a Dog Heart Failure Model." [Poster Presentation #017] has been displayed today and will be presented at 5:45 pm ET by Fady Malik, M.D., Ph.D., F.A.C.C., Director, Cardiovascular Programs, Cytokinetics. The presentation details research directed to the discovery and optimization of small molecules that improve cardiac function in a manner consistent with the therapeutic hypothesis, specifically that improving cardiac contractility by directly activating cardiac myosin can potentially address the liabilities of current inotropic drugs. The data demonstrate that CK-1827452 selectively activates cardiac myosin. In cardiac myocytes, CK-1827452 increases contractility without changes in the cellular calcium transient, a finding consistent with its mechanism of action. In addition, CK-1827452 demonstrates an improvement in cardiac function and output, hemodynamics and efficiency in a dog model of heart failure in a manner that supports the therapeutic hypothesis.

The presen
'"/>

Contact: Justin Jackson
jjackson@burnsmc.com
212-213-0006
Burns McClellan
19-Sep-2005


Page: 1 2 3 4

Related biology news :

1. Progenika Biopharma presents a biochip that guarantees safety in blood transfusions
2. SNM presents awards on Capitol Hill
3. ESA presents the sharpest ever satellite map of Earth
4. New book presents neurobiology from an evolutionary perspective
5. Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
6. Childrens Hospital and Research Center-Oakland presents a new maternal diet study
7. USGS presents a world of science at GSA in Philadelphia
8. Childrens Hospital Boston presents at the 2006 American Academy of Pediatrics National Conference
9. DFG presents the 2006 MAK and BAT value list
10. Childrens Hospital Boston presents at the 2006 Pediatric Academic Societies annual meeting
11. Kereos presents at AAAS, discusses nanotech-based disease diagnosis and treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week ... , “We help innovative projects connect with Chinese pharma and investors in healthcare innovation,” ... on to explain that as a part of Biotech Week Boston – the annual ...
(Date:8/14/2019)... ... ... Julie Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... her own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his ... body was weak, and he struggled to play fetch and other games with his family. ...
(Date:8/6/2019)... ... August 06, 2019 , ... VetStem Biopharma ... and GMP manufacturing experience. In November it spun out a human regenerative ... experience and one of the first cGMP cell manufacturing facilities in California ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), a ... the FDA for use of a person’s own adipose-derived stem cells to treat their ... the knee. This IND is the first of several planned clinical trials which ...
(Date:6/11/2019)... ... June 10, 2019 , ... Thought Technology Ltd is pleased ... Biofeedback Tech Ltd as its authorised distributor for the UK and ... therapeutic treatments and clinical assessment protocols to treat stress related disorders as well ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. ... continually expanding library of more than 20 million articles, sourced from more than ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative ... Inc. (PSC) , has announced that their GMP facility for cell production is ... for manufacturing. This is an important milestone for VetStem as it expands ...
Breaking Biology Technology:
Cached News: