HOME >> BIOLOGY >> NEWS
Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

A new study conducted by researchers from the University of Verona and the Institute G. Gaslini in Genova, Italy, confirms the pivotal role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis.

Atherosclerosis is the main cause of morbidity and mortality worldwide. Classic risk factors including smoking, diabetes, hypertension and high cholesterol levels are known to play a pivotal role in the pathogenesis of the disease that also recognises a genetic influence. However, it is well known that acute cardiovascular events may happen without the presence of the mentioned common risk factors. Recently inflammation and infectious agents have been shown to play an important role in the onset of acute cardiovascular events.

The online, open-access PLoS ONE publishes a new study on the relationship between Cytomegalovirus infection and atherosclerosis, conducted by Prof. Roberto Corrocher and Claudio Lunardi from the University of Verona and by Prof. Antonio Puccetti from the Institute G. Gaslini in Genova, Italy.

The same researchers have already shown that Cytomegalovirus infection can be responsible of the initial vascular lesions typical of the atherosclerotic process. The mechanism involved in the vascular lesion is of autoimmune origin: antibodies directed against particular proteins of the virus are able to bind molecules expressed on the surface of the cells that line the arterial walls (endothelial cells) and to cause their death (apoptosis) through a mechanism called "molecular mimicry."

Using a biocomputational technique, the new study shows that the same anti-Cytomegalovirus antibodies, isolated from patients with coronary artery disease, are able to induce the activation not only of genes involved in apoptosis but also of many other genes that encode for proteins involved in different aspects of the atherosclerotic process (lipid metabolism, inflammation, adhesion molecules, etc.). For the first
'"/>

Contact: Claudio Lunardi
claudio.lunardi@univr.it
Public Library of Science
29-May-2007


Page: 1 2

Related biology news :

1. Cigarette smoke exacerbates alcohols effects on defense against Streptococcus pneumoniae
2. Cigarette smoking exacerbates alcohol-induced brain damage
3. High cholesterol diets modify gene expression in atherosclerosis
4. Two drugs may stabilize plaques in atherosclerosis
5. Beyond lipids: understanding the mechanics of atherosclerosis
6. PET/CT offers superior view of atherosclerosis plaque, may identify those at risk for heart attack
7. Japanese researchers get to the heart of atherosclerosis
8. Chronic stress accelerates atherosclerosis following angioplasty procedure
9. Inherent vascular repair key to atherosclerosis
10. New findings in innate immunity may lead to treatments for atherosclerosis
11. Experimental lupus drug may also work against atherosclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... ... Experiential tourism, a trend encompassing culinary travel, cultural exploration and activity-based travel ... according to a recent report by Skift, a media company for the travel industry, ... are wanting their journeys to be authentic and unique, and good cuisine has shown ...
(Date:5/21/2019)... , ... May 20, 2019 , ... ... health care field, today announced a 96.15% pass rate for first-time test takers ... This surpasses the national average of 76.43% by nearly 20 points. , ...
(Date:5/14/2019)... ... 14, 2019 , ... IMMUNE 3D®, a privately held biotechnology ... of autoimmunity, fibrosis and skin immunology. In addition, the company will leverage its ... efforts. , IMMUNE 3D®’s proprietary platform aims to study factors that affect ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... ... April 30, 2019 , ... By ... USA Inc. has demonstrated its ability to provide various services and products ... enhance customer satisfaction through the effective implementation of its quality management system, ...
(Date:5/2/2019)... ... , ... Boston Robotic Hair Restoration announces the most advanced ... of painful hair transplant procedures. Boston Robotic Hair Restoration offers the newest, state-of-the-art ... solution to offer a minimally invasive procedure. With the ARTAS® iX robotics, patients ...
(Date:4/16/2019)... (PRWEB) , ... April 16, 2019 , ... ... Blue Sources and their project partner, the U.S. Army Center for Environmental Health ... Aquatic Biomonitor Through Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company located at ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... locked into multiple agreements to help companies advance their innovations to clinical ... ranging from synthetic biology companies that are gene editing therapeutic cells for ...
Breaking Biology Technology:
Cached News: