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DARPA grant supports research toward realizing tissue regeneration

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  • Lorraine Gudas, Ph.D., chairman of the pharmacology department and Revlon Pharmaceutical Professor of Pharmacology and Toxicology, Weill Medical College of Cornell University, New York City, an expert in retinoid pharmacology, stem cells and cell differentiation
  • Ellen Heber-Katz, Ph.D., professor, molecular and cellular oncogenesis program, The Wistar Institute in Philadelphia, who previously identified a unique mouse model, the MRL mouse, with unusual regenerative properties and has been studying the genetics and the cellular, molecular and immune pathways involved in this response
  • Shannon Odelberg, Ph.D., assistant professor, departments of internal medicine and neurobiology and anatomy, University of Utah, Salt Lake City, whose work focuses on the molecular basis for limb regeneration in newts
  • Hans-Georg Simon, Ph.D., a developmental biologist and assistant professor of pediatrics, Children's Memorial Research Center and Northwestern University in Chicago, who studies the relationship between vertebrate limb development and limb regeneration

    "We sincerely believe that the ability to promote tissue restoration in humans is not only possible, it will in fact be a reality some day. By working as a team and capitalizing on our collective expertise and experience, we're in a better position to succeed at unlocking the regenerative potential of mammals than would be possible working in the silos of our individual labs," said Dr. Badylak. The investigators believe their goal is attainable due to a convergence of recent discoveries made in their labs as well as at other institutions in the areas of stem cell research, extracellular matrix biochemistry and the regulation of gene expression.

    To some extent, humans already have the capacity for regeneration. For instance, certain cells, such as liver cells and red blood cells, can self-renew; and during embry
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    • 2-May-2006


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