The re-evaluation of earlier MAK values was conducted intensively, also in close cooperation with the European (SCOEL) and the American (TLV) Commissions. It was decided in the course of this examination to suspend the MAK values of three substances (antimony, trinitroglycerol, and vanadium pentoxide) because of their suspected carcinogenicity and of disulphur decafluoride, fluorine, and iodine because of insufficient data for a health evaluation.
Twenty-two working substances were also examined with respect to being particularly harmful during pregnancy. Acrylic acid, fluorides, d-limonenes, methacryl acid, perfluorooctane acid, phosphor pentachloride, phosphoric acid, and hydrogen peroxide were assigned to group C which contains those substances for which no teratogenicity is anticipated if the MAK values are adhered to. 2-ethylhexanol, hydrogen fluoride, glutardialdehyde, methyl acetate, methyl methacrylate, N-methyl-2-pyrrolidone, and phosphorus pentoxide remain in this group. By contrast, 2-butine-1,4-diol, phosphorus trichloride, m-phthalic acid, p-phthalic acid, and tetrahydrothiophene were assigned to pregnancy group D which essentially states that classification into group C is not yet possible due to the available data. A risk of harming the embryo currently appears unlikely if the MAK values are complied with but cannot be ruled out with sufficient certainty. Despite new studies, N,N-dimethylformamide remains in Group B for substances, for which teratogenicity cannot be ruled out even if the MAK value is not exceeded.
This year, a total of 16 working substances were examined for their respiratory tract and skin sensitising properties. New labelling was assigned to eleven chemicals, i. e. benomyl, bromelain, 2-butene-1,4-diol, tert-butylacrylate, p-chloro-m-cresol, 3,4-Dichloroaniline, fa
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Contact: Dr. Jutta Rateike
Jutta.Rateike@dfg.de
49-228-885-2665
Deutsche Forschungsgemeinschaft
22-Jul-2005