HOME >> BIOLOGY >> NEWS
DNA ends: Common tool, different job

Every time a cell repairs or replicates its DNA, the resulting single strand is wrapped up by a dedicated protein complex. In eukaryotes or organisms whose cells have a nucleus, this job is handled by a tripartite complex called replication protein A (RPA). Researchers at the Salk Institute for Biological Studies have now unearthed a novel RPA-like complex that specifically homes in on the short single-stranded DNA "tail" end of yeast chromosomes.

Their findings, reported in the online edition of Nature Structural & Molecular Biology, will help scientists to better understand the dynamics that keep chromosomes ends, called telomeres, intact.

"Identification of this new RPA-like complex, which is targeted to a specific region of the genome, suggests that multiple RPA-like complexes have evolved, each making individual contributions to genomic stability," says the study's lead author Vicki Lundblad, Ph.D., a professor in the Molecular Cell Biology Laboratory at the Salk Institute.

With each round of cell division, telomeres long stretches of repetitive DNA erode a little bit further. Some have likened this progressive shortening to a genetic biological clock that winds down over time. In fact, when telomeres reach a "critical length," the cell can no longer multiply a characteristic sign of cellular senescence.

In certain cells, such as our germ cells or baker's yeast cells, which need to divide indefinitely, an enzyme called telomerase elongates telomeres to compensate for the continual attrition at chromosome ends. At the same time, telomerase activity is the main mechanism by which human tumor cells achieve immortal growth.

In addition, the natural ends of chromosomes could potentially look like broken strands of DNA that a cell's repair machinery is designed to fix. This has been a long-standing puzzle, because mending chromosome ends as though they were double-strand breaks would result in either unregulat
'"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100, ext. 1340
Salk Institute
13-Feb-2007


Page: 1 2

Related biology news :

1. Common environmental chemicals in diet affect fetal ovarian development
2. Common cancer gene sends death order to tiny killer
3. Common treatment for methamphetamine overdose may damage brain cells
4. Common genetic variation is linked to substantial risk for heart attack
5. Common fungicide causes long-term changes in mating behavior
6. Common gene version optimizes thinking -- but with a possible downside
7. Common mechanisms for viral DNA replication
8. Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia
9. Common cause of heart disease, diabetes may be treatable with malaria drug
10. Commonplace sugar compound silences seizures
11. Common garden plant threatened by climate change

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... LAKE CITY, and MARTINSRIED, Germany (PRWEB) , ... ... ... in high-throughput antibody screening and characterization, announced today that they have opened a ... Carterra’s platform has fueled the need for the new office. , The Munich ...
(Date:8/14/2019)... JOLLA, Calif. (PRWEB) , ... August 14, 2019 , ... ... insight into their future children, announces inclusion in the 38th annual Inc. 500|5000 ... been eligible to apply. To qualify, companies must have been founded and generating revenue ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in healthcare to ... patients will visit urgent care centers (UCC) in the coming years, according to a ... The Market for Urgent Care Centers , is a detailed look at the current ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... ... on prepackaged mobile phases for QC laboratories. After gaining a few significant clients, ... sciences approach into a valued supplier of manufacturing processing solutions, including reagents for ...
(Date:8/6/2019)... ... August 06, 2019 , ... ... characterizing microbiome populations down to the strain level, has announced partnerships with six ... other products to companies and research organizations in Australia, Benelux, Indonesia, Korea, Malaysia, ...
(Date:7/30/2019)... SAN DIEGO (PRWEB) , ... July 30, 2019 ... ... Lajollacooks4u, San Diego’s premiere team building and cooking events company. Not only has ... but it has also started offering Private Cooking Parties to its guests. , ...
(Date:7/19/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... July 18, ... ... who is also known as “Ravi Everest,” will be joining forces with California-based ... to be held from July 20-22nd. Coalition Duchenne raises awareness and funding for ...
Breaking Biology Technology:
Cached News: