HOME >> BIOLOGY >> NEWS
DNA ends: Common tool, different job

ed degradation or end-to-end fusions. Such repair events are lethal for the genome, and in certain settings, can promote the development of cancer.

About 10 years ago, Lundblad discovered that Cdc13, a protein that binds single-stranded telomeric DNA, plays a central role at the telomeres of baker's yeast. But the function of two Cdc13-associated proteins, Stn1 and Ten1, remained unclear.

When members of the Lundblad laboratory searched the Protein Data Bank for relatives of Stn1, they dug up Rpa2, the middle subunit of the RPA complex. In particular, Stn1 and Rpa2 share similarities in a region known as oligonucleotide/oligosaccharide-binding fold or OB-fold, a protein fold that is commonly used to recognize and bind to either DNA or RNA.

Based on these findings, Lundblad and her colleagues developed a model, which predicts that Cdc13, Stn1 and Ten1 come together at the very end of chromosomes to form a telomere-dedicated RPA-like complex they dubbed the t-RPA complex.

Graduate student and first author Hua Gao tested this model, using detailed biochemical experiments which revealed that Stn1 and Ten1 behave just like their counterparts in the conventional RPA complex. However, Stn1 and Ten1 have the same predilection for single-stranded telomeric DNA as Cdc13, thereby helping to ensure that this complex only targets chromosome tips.

According to Lundblad, this finding raises important questions about the potential biological parallels between the conventional RPA complex and the newly discovered t-RPA complex.

"Whereas the conventional RPA complex acts elsewhere in the genome to raise a red flag to attract the attention of the repair machinery," says Lundblad, "curiously, the t-RPA complex performs the exact opposite function at chromosome ends, ensuring that these tips do not become targets for DNA repair."


'"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100, ext. 1340
Salk Institute
13-Feb-2007


Page: 1 2

Related biology news :

1. Common environmental chemicals in diet affect fetal ovarian development
2. Common cancer gene sends death order to tiny killer
3. Common treatment for methamphetamine overdose may damage brain cells
4. Common genetic variation is linked to substantial risk for heart attack
5. Common fungicide causes long-term changes in mating behavior
6. Common gene version optimizes thinking -- but with a possible downside
7. Common mechanisms for viral DNA replication
8. Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia
9. Common cause of heart disease, diabetes may be treatable with malaria drug
10. Commonplace sugar compound silences seizures
11. Common garden plant threatened by climate change

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... , ... May 27, 2020 , ... ... Workforce Advisor™ , a solution that uniquely combines lab testing insights and ... employers systematically support the ongoing health and safety of employees returning to the ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... IntegritySM technology-based services specializing in background and medical screening, announces the launch ... planning and keeping their workforce safe. The new service is provided by ...
(Date:5/15/2020)... ... May 15, 2020 , ... The National Institutes of Health (NIH) ... based in Frederick, Maryland and Tysons Corner, Virginia, to provide patent legal services under ... another in the field of chemistry. The firm is one of nine firms in ...
Breaking Biology News(10 mins):
(Date:5/30/2020)... ... May 29, 2020 , ... The ... the first newsletter solely dedicated to the unique role of the Chief Medical ... perspectives on the responsibilities, problem-solving, best practices and career development of CMOs and ...
(Date:5/26/2020)... ... May 26, 2020 , ... Brilliant , the leading smart home ... garage door openers, announce a new integration to bring more convenience, simplicity, and security ... powered by Aladdin Connect® can now be controlled from Brilliant’s in-wall touchscreen control panels ...
(Date:5/21/2020)... ... May 19, 2020 , ... Eaton Square is pleased to announce its ... Company, a biotechnology and medical technology-focused strategy and M&A advisory firm. , This is ... States, linking US and Asia Pacific healthcare innovators with capital and investors. , Popper ...
(Date:5/15/2020)... ... 2020 , ... Children with defective heart valves often have ... adults. The reason: there are no heart valve prosthetics designed to grow with ... Defense has awarded Draper, Boston Children’s Hospital and Seattle Children’s Research Institute a ...
Breaking Biology Technology:
Cached News: