HOME >> BIOLOGY >> NEWS
DNA layer reduces risk of reserve parts being rejected

Dutch researchers Jeroen van den Beucken and John Jansen have given body implants a DNA layer. This layer ensures a better attachment, more rapid recovery of the surrounding tissue and less immune responses. The older we get the more 'reserve-parts' we need. Up until now placing such parts yielded advantages, but also disadvantages such as inflammations and immune responses. Van den Beucken's invention makes it easier and more reliable to use implants and has already been patented.

Van den Beucken reasoned that a DNA coating should have a lot of advantages. Such a coating approximates the body's own material with the result that a less intense immune response occurs. Further DNA is rich in phosphate groups that can speed up the attachment to bone tissue and therefore the integration of bone implants in the native bone tissue. Finally, DNA can be enriched with biologically active factors that, for example, facilitate the formation of bone tissue and blood vessels. All in all, a DNA coating could be safe, reduce the immune response, facilitate bone attachment and be functionalisable.

Layer by layer

However, enzymes in the body will quickly break down a DNA coating. A method therefore had to be found to firmly attach the DNA to the implant surface. Van den Beucken used the Layer-by-Layer deposition technique (see Figure 1) to produce a multilayer coating. This coating was tested in cell cultures and animal experiments for its safety, immune response, bone attachment and functionalisation. The DNA layer was also found to speed up the deposition of calcium phosphate and could, for example, be adapted to promote bone and blood vessel formation. The good research results led to the patenting of DNA coatings for implants. A biomedical company is currently investigating whether they can take over the patent.

Layer-by-Layer deposition technique. With this technique, ultra-thin DNA layers can be built up and immobilized. The fir
'"/>

Contact: Jeroen van den Beucken
j.vandenbeucken@dent.umcn.nl
312-436-4461
Netherlands Organization for Scientific Research
25-Mar-2007


Page: 1 2

Related biology news :

1. Throwing motion in young baseball players may actually protect shoulder
2. Weizmann Institute scientists discover a key player in embryonic muscle development
3. Plant size morphs dramatically as scientists tinker with outer layer
4. Birth rate, competition are major players in hominid extinctions
5. New player in commitment to life as a fat cell
6. Brown cancer biologists identify major player in cell growth
7. Hopkins researchers uncover critical player in cell communication
8. A new player in nuclear import of HIV-1
9. Pregnant drivers, football players safer thanks to a top Virginia Tech researcher
10. Dartmouth researchers find key player in immune system regulation
11. Ghrelin: A player in diabetes but not obesity?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... August 15, 2019 , ... Deep Science Ventures (DSV), ... Agriculture practice, a new unit dedicated to building 100 companies over the next 10 ... and supply chains. , Deep Science Ventures was founded to create a better ...
(Date:8/14/2019)... ... August 14, 2019 , ... Join Jonathan Riek, PhD, VP, Musculoskeletal & ... September 10, 2019 at 1pm EDT to learn about two common imaging methods in ... NAFLD is the most common diffuse liver disease, with a worldwide prevalence of 20-46 ...
(Date:8/9/2019)... ... , ... With a demand in healthcare to lower unneeded emergency room visits ... centers (UCC) in the coming years, according to a new report on the industry ... Centers , is a detailed look at the current state of these healthcare outlets, ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... , ... July 08, 2019 , ... ... The company’s SmartLight Indicator was recognized as the 2019 Innovative Product of the ... forward. The prestigious awards were during Sensors Expo & Conference 2019, ...
(Date:6/26/2019)... , ... June 26, 2019 , ... Alice Branton today ... on improving physicochemical properties of Magnesium Gluconate, which can prove to be beneficial for ... alteration of characteristic differentiation peak, change in crystallite size , Over 142% ...
(Date:6/18/2019)... Calif. (PRWEB) , ... June 18, 2019 , ... ... an Investigational New Drug (IND) application to the FDA for use of a person’s ... cells as a treatment of osteoarthritis in the knee. This IND is the ...
(Date:6/11/2019)... ... 10, 2019 , ... Thought Technology Ltd is pleased to ... Biofeedback Tech Ltd as its authorised distributor for the UK and Ireland. ... treatments and clinical assessment protocols to treat stress related disorders as well as ...
Breaking Biology Technology:
Cached News: