DNA 'packaging' linked with cancer

f normal cells, the entire genome became resistant to enzyme digestion. The UIC scientists were able to induce exactly the same effect after just one edge of a normal cell came into contact with laminin, a component of the extracellular matrix.

"Tests showed that in the presence of laminin, the activity of close to 1,000 genes was affected," Folberg said.

Additional experiments demonstrated that the molecules outside a cell exert their influence not by chemical means but mechanically, manipulating the skeletal framework of the cell and the proteins that envelop DNA. These proteins keep the string of DNA -- really, a stiff wire with component nucleotides -- tightly compressed; if the proteins are removed, the genes spring out like a jack-in-the-box.

When the researchers disassembled a cell's skeletal elements -- microtubules, actin and intermediate filaments -- not only did the cell's shape change, but its DNA took on new contours. Segments of DNA became buried inside the wad of genetic material, inaccessible to enzyme digestion.

"Medical research has for decades focused on finding the underlying genetic abnormalities that cause disease, but this work demonstrates that genes themselves are controlled by components outside the nucleus and these, in turn, are regulated by the cell's microenvironment," Maniotis said.

The discovery that normal, benign and malignant tissues respond differently to enzyme digestion could lead to a new diagnostic tool for distinguishing different types of tumors.

The researchers also believe that their findings suggest new therapeutic strategies for combating cancer.

"Many current forms of chemotherapy target DNA directly and are associated with significant side effects," Folberg said. "We're developing methods of manipulating the genome that may be non-toxic and still highly effective."

Other researchers involved in the study were Klara Valyi-Nagy, John Karavitis, Jonas Mos

Contact: Sharon Butler
University of Illinois at Chicago

Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Risk of common vaginal infection linked to preterm birth appears higher for blacks
3. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
4. Antibody linked to MS significantly higher in spinal fluid of blacks
5. Loss of cells antenna linked to cancers development
6. Scientists identify first gene linked to scoliosis
7. Gum disease in postmenopausal women linked to oral bone loss
8. Screening approach leads to discovery of gene linked to breast cancer
9. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
10. Dietary preferences and patterns may be linked to genes
11. Malaria and Epstein-Barr virus linked to pediatric cancer in Africa

Post Your Comments:

(Date:8/23/2017)... public,s help is being enlisted in what,s thought to be the biggest ... human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date ... project's goal is to help advance scientific knowledge of the role of ... The ...
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
(Date:10/10/2017)... Parks Associates announced today that Tom Kerber , Director ... , October 11 in Scottsdale, Arizona . Kerber will ... safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction of ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, announces a ... in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: