HOME >> BIOLOGY >> NEWS
DNA scans reveal possible location of lung cancer genes

BOSTON--With equipment designed to probe the smallest segments of the genetic code, researchers at Dana-Farber Cancer Institute and collaborating institutions have found something much larger: sections of the chromosomes of lung cancer cells where cancer-related genes may lurk.

In a study in the July 1 issue of the journal Cancer Research, the researchers used single nucleotide polymorphism (SNP) array technology, which focuses on the building blocks of individual genes, to identify regions of chromosomes where genes were either left out or multiplied over and over mistakes that are often associated with cancer. In this effort, SNP (pronounced "snip") arrays have been used to find gene-copy errors in lung cancer cells.

"In a previous study, we showed that SNP arrays offer a unique way of locating copy-number changes in cell chromosomes and of determining when genes on a pair of chromosomes are mismatched," says the study's senior author, Matthew Meyerson, MD, PhD, of Dana-Farber. "The current study demonstrates that high-resolution SNP technology is powerful enough to identify copy-number alterations that previously hadn't been found in lung cancer cells."

Working with 70 specimens of lung cancer tissue and 31 laboratory-grown lines of lung cancer cells, the investigators used high-resolution machinery to scan the cells' chromosomes in 115,000 locations. They found several areas that had already been identified as having copy-number errors, plus five new ones two where genes had been deleted, and three where they had been highly over-copied.

The next step will be to identify the specific genes involved in these alterations. That, in turn, could lead to new diagnostic tests and treatments for lung cancer, by far the most common form of cancer in the United States, and one of the most difficult to treat.

There is increasing evidence that therapies aimed at specific gene abnormalities can be effective in treating cance
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
1-Jul-2005


Page: 1 2

Related biology news :

1. Ancient Etruscans were immigrants from Anatolia, or what is now Turkey
2. Ancient Etruscans unlikely ancestors of modern Tuscans, statistical testing reveals
3. Numerical processing similar in children and adults, brain scans reveal
4. Expert system developed to enhance diagnostic accuracy of Alzheimers disease with FDG PET scans
5. PET scans predict development of lung disease following trauma
6. Brain scans reveal how gene may boost schizophrenia risk
7. PET/MRI scans may help unravel mechanisms of prenatal drug damage
8. Automated scans let scientists track drugs broad effects on cells
9. Study begins to reveal clues to the cause and progression of sepsis
10. Satellite tracking reveals threats to Borneo pygmy elephants
11. New technology reveals seal behavior

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, based ... entered into license agreements with Housey Pharma’s HMI subsidiary to gain access to ... have annual Research and Development spending in excess of US $10 billion. , ...
(Date:8/7/2020)... ... 06, 2020 , ... Nine middle school teachers from eight ... a unique professional development program that provides advanced STEM (science, technology, engineering and ... nationwide. , Created in partnership between the National Stem Cell Foundation and The ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, ... contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) ... develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... testing services and products, announces a significant expansion of laboratory operations through its ... collection for agencies implementing testing programs. , Bode-CARES provides a ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien ... announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical ... development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an Emeritus ...
(Date:7/1/2020)... CHARLOTTE, N.C. (PRWEB) , ... June 29, 2020 ... ... has reported year to date growth of 40% in 2020, despite many obstacles ... medical technology, MedShift aims to increase revenue for its partnered medical practices and ...
(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... The Indoor ... launch of Safe Space™ for businesses of all types to ensure cleanliness, distancing and ... , A Safe Space™ enabled business will provide a health performance index ...
Breaking Biology Technology:
Cached News: