HOME >> BIOLOGY >> NEWS
DNA sieve -- Nanoscale pores can be tiny analysis labs

ncharged polymer polyethylene glycol (PEG) were substituted for biomolecules. Each type of PEG molecule reduced the nanopore's electrical conductance differently as it moved through, allowing the researchers to distinguish one size of PEG chain from another.

As a control, a solution of a highly purified PEG of a specific size was characterized with the nanopore. The resulting "fingerprint" closely matched the one identifying samples of the same size polymer in the mixed chain solution.

Further enhancement of the data from both the experimental and control tests yielded mass measurements and identifications of the different PEG chains that correlate with those made by traditional mass spectrometry.

Because the dimensions of the lipid bilayer and the alpha-hemolysin pore, as well as the required amount of electrical current, are at the nanoscale level, the "single-molecule mass spectrometry" technology may one day be incorporated into "lab-on-a-chip" molecular analyzers and single-strand DNA sequencers.


'"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
11-May-2007


Page: 1 2

Related biology news :

1. MIT microsieve could aid study of diseases
2. MITs molecular sieve advances protein research
3. AEA, UAlbany College of Nanoscale Science and Engineering to partner on CIRCA 07
4. Nanoscale microscope sheds first light on gene repair
5. Researchers track how spores break out of dormant state
6. Single molecular mark seen as pivotal for genome compaction in spores and sperm
7. Airborne mold spores increase kids risk for multiple allergies
8. Researchers solve mystery of how nuclear pores duplicate before cell division
9. Anthrax spores may survive water treatment
10. Pillows - a hot bed of fungal spores
11. Virginia Tech experts available to speak on the possible discovery of Asian Soybean Rust spores

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... LOUISVILLE, Ky. (PRWEB) , ... August 06, 2020 ... ... been selected to participate in the prestigious National STEM Scholar Program, a unique ... national network building, and project support for middle school science teachers nationwide. , ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today announced a ... Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the Department of ... a highly efficient mammalian cell culture-based bioprocess suitable to meet surge requirement needs ...
(Date:7/18/2020)... ... 2020 , ... A study has been published in the ... noise control device to attenuate typical noises in a simulated neonatal intensive care ... sounds from patient monitors, ventilators and other bedside devices that would affect the ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... ... announces it has closed on the purchase of greenfield for a new, expanded ... and includes over 21 acres in the initial acquisition, with an option to ...
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its ... MediVet Biologics since its formation in 2016, the company is relaunching itself under the ... on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products ... three different materials for use with CRM, neurostimulation, vascular, and related devices. , ... meet specific design requirements, performance, and cost criteria; especially where solid wire is ...
Breaking Biology Technology:
Cached News: