HOME >> BIOLOGY >> NEWS
DNA to the defense

CAMBRIDGE, U.K., Fri., Aug 4, 2006 -- A team of scientists headed by Dr. Sara Melville at the University of Cambridge has shown that the parasite known to cause African sleeping sickness has evolved an unusual chromosomal structure as a result of environmental adaptation. In this parasite, the chromosomes are highly enriched in subtelomeric sequences dynamic and variable regions that connect the chromosome ends to the gene-rich cores. These subtelomeres, in some cases comprising 75% of the total chromosome length, contain a large repertoire of genes involved in circumventing the human immune response. This finding challenges scientists' general view of how a chromosome is functionally organized. An article describing the research will appear online this week in the journal Genome Research.

African sleeping sickness, or trypanosomiasis, is caused by a protozoan parasite known as Trypanosoma brucei. Endemic to sub-Saharan Africa, it is transmitted by tsetse flies and infects a variety of mammals, including humans. There are no vaccines against T. brucei, and most drugs to treat the disease have dangerous side effects or are scarce in the countries most heavily afflicted. Each day, the disease kills approximately 100 people.

In order to avoid destruction by mammalian immune systems, T. brucei continually changes the expression of the proteins on its outer surface. These proteins are encoded by VSGs, or variant surface glycoprotein genes. While the immune system attacks most of the parasites in a given host, some trypanosomes rapidly evolve and express new variants of VSG, thereby allowing the parasite to persist and spread through a population.

In the current study, Sergio Callejas, a Marie Curie Research Fellow in Melville's laboratory and the first author on the manuscript, conducted a series of experiments to demonstrate that T. brucei has used a strategy of chromosomal expansio
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
3-Aug-2006


Page: 1 2

Related biology news :

1. Rapid evolution of defense genes in plants may produce hybrid incompatibility
2. Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores
3. Research ends debate over benefits of butterfly defenses
4. On the defense: Conserved features of plant innate immunity
5. How plague-causing bacteria disarm host defense
6. Biodesign Institute takes part in $14.4M NIH chemical defense grant
7. Gene knockouts reveal FoxOs vital functions in cancer defense, health of stem cells
8. ASM Biodefense and Emerging Diseases Research Meeting
9. Molecular on/off switch controls immune defenses against viruses
10. Newly discovered immune defense may be impaired in CF airways
11. Counter defense strategy of virus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... 15, 2017 After spending the past two years building ... data collection, GeneFo now offers this platform to healthcare stakeholders (hospitals, ... support, adherence, and data collection vis a vis their members, under ... successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... PA (PRWEB) , ... August 15, 2017 , ... ... one of the largest Asian exhibitions for analytical and scientific instruments. This year’s ... will be “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation ...
(Date:8/15/2017)... York, NY (PRWEB) , ... August 15, 2017 , ... ... the first time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming panels ... be held February 7-9, 2018, at The Roosevelt Hotel in New York City. , ...
(Date:8/14/2017)... ... August 14, 2017 , ... ... performing antibodies. Key researchers in the antibody community have recently come together to ... for antibodies in the laboratory. , The team at Thermo ...
Breaking Biology Technology:
Cached News: