HOME >> BIOLOGY >> NEWS
DNA to the defense

CAMBRIDGE, U.K., Fri., Aug 4, 2006 -- A team of scientists headed by Dr. Sara Melville at the University of Cambridge has shown that the parasite known to cause African sleeping sickness has evolved an unusual chromosomal structure as a result of environmental adaptation. In this parasite, the chromosomes are highly enriched in subtelomeric sequences dynamic and variable regions that connect the chromosome ends to the gene-rich cores. These subtelomeres, in some cases comprising 75% of the total chromosome length, contain a large repertoire of genes involved in circumventing the human immune response. This finding challenges scientists' general view of how a chromosome is functionally organized. An article describing the research will appear online this week in the journal Genome Research.

African sleeping sickness, or trypanosomiasis, is caused by a protozoan parasite known as Trypanosoma brucei. Endemic to sub-Saharan Africa, it is transmitted by tsetse flies and infects a variety of mammals, including humans. There are no vaccines against T. brucei, and most drugs to treat the disease have dangerous side effects or are scarce in the countries most heavily afflicted. Each day, the disease kills approximately 100 people.

In order to avoid destruction by mammalian immune systems, T. brucei continually changes the expression of the proteins on its outer surface. These proteins are encoded by VSGs, or variant surface glycoprotein genes. While the immune system attacks most of the parasites in a given host, some trypanosomes rapidly evolve and express new variants of VSG, thereby allowing the parasite to persist and spread through a population.

In the current study, Sergio Callejas, a Marie Curie Research Fellow in Melville's laboratory and the first author on the manuscript, conducted a series of experiments to demonstrate that T. brucei has used a strategy of chromosomal expansio
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
3-Aug-2006


Page: 1 2

Related biology news :

1. Rapid evolution of defense genes in plants may produce hybrid incompatibility
2. Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores
3. Research ends debate over benefits of butterfly defenses
4. On the defense: Conserved features of plant innate immunity
5. How plague-causing bacteria disarm host defense
6. Biodesign Institute takes part in $14.4M NIH chemical defense grant
7. Gene knockouts reveal FoxOs vital functions in cancer defense, health of stem cells
8. ASM Biodefense and Emerging Diseases Research Meeting
9. Molecular on/off switch controls immune defenses against viruses
10. Newly discovered immune defense may be impaired in CF airways
11. Counter defense strategy of virus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... , March 15, 2016 ... report published by Transparency Market Research "Digital Door Lock Systems ... Forecast 2015 - 2023," the global digital door lock systems ... Mn in 2014 and is forecast to grow at a ... of micro, small and medium enterprises (MSMEs) across the world ...
(Date:3/11/2016)... -- --> --> ... Market by Technology (Pattern Recognition), by Component (Hardware, Software, ... (On-Premises and Cloud), by Industry Vertical and by Region ... global market is expected to grow from USD 12.49 ... at a CAGR of 19.1%. , ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... May 4, 2016 According to ... "Metabolomics Market - Global Industry Analysis, Size, Share, Growth, ... is anticipated to expand at a CAGR of 17.1% ... by 2024. Metabolomics is the extensive study ... biofluids, tissues or organisms. Together, these small molecules and ...
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published by the Boston Business ... fastest-growing private companies; a small percentage of the state's 615,000+ small businesses. The list ... change in revenue from 2012 to 2015. , As this award comes ...
(Date:5/3/2016)... , May 3, 2016 ... Assessing Developers and Producers of Those Competitor Biologics  ... to Companies, Activities and Prospects ,  Who ... companies? And what are their sales potentials? Discover, ... you see results, trends, opportunities and revenue forecasting. ...
(Date:5/2/2016)... ... May 02, 2016 , ... Meister Media Worldwide launches ... look and added functionality give the agricultural world a taste of Meister Media ... in agriculture – from precision farming via satellites and Unmanned Aerial Vehicles (UAVs) ...
Breaking Biology Technology:
Cached News: