HOME >> BIOLOGY >> NEWS
DNA to the defense

CAMBRIDGE, U.K., Fri., Aug 4, 2006 -- A team of scientists headed by Dr. Sara Melville at the University of Cambridge has shown that the parasite known to cause African sleeping sickness has evolved an unusual chromosomal structure as a result of environmental adaptation. In this parasite, the chromosomes are highly enriched in subtelomeric sequences dynamic and variable regions that connect the chromosome ends to the gene-rich cores. These subtelomeres, in some cases comprising 75% of the total chromosome length, contain a large repertoire of genes involved in circumventing the human immune response. This finding challenges scientists' general view of how a chromosome is functionally organized. An article describing the research will appear online this week in the journal Genome Research.

African sleeping sickness, or trypanosomiasis, is caused by a protozoan parasite known as Trypanosoma brucei. Endemic to sub-Saharan Africa, it is transmitted by tsetse flies and infects a variety of mammals, including humans. There are no vaccines against T. brucei, and most drugs to treat the disease have dangerous side effects or are scarce in the countries most heavily afflicted. Each day, the disease kills approximately 100 people.

In order to avoid destruction by mammalian immune systems, T. brucei continually changes the expression of the proteins on its outer surface. These proteins are encoded by VSGs, or variant surface glycoprotein genes. While the immune system attacks most of the parasites in a given host, some trypanosomes rapidly evolve and express new variants of VSG, thereby allowing the parasite to persist and spread through a population.

In the current study, Sergio Callejas, a Marie Curie Research Fellow in Melville's laboratory and the first author on the manuscript, conducted a series of experiments to demonstrate that T. brucei has used a strategy of chromosomal expansio
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
3-Aug-2006


Page: 1 2

Related biology news :

1. Rapid evolution of defense genes in plants may produce hybrid incompatibility
2. Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores
3. Research ends debate over benefits of butterfly defenses
4. On the defense: Conserved features of plant innate immunity
5. How plague-causing bacteria disarm host defense
6. Biodesign Institute takes part in $14.4M NIH chemical defense grant
7. Gene knockouts reveal FoxOs vital functions in cancer defense, health of stem cells
8. ASM Biodefense and Emerging Diseases Research Meeting
9. Molecular on/off switch controls immune defenses against viruses
10. Newly discovered immune defense may be impaired in CF airways
11. Counter defense strategy of virus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... ... communications and collaboration solutions, was present at Microsoft Ignite 2018, in Orlando, Florida, ... solutions. , Microsoft issued a statement about the new direction of Skype for ...
(Date:10/5/2018)... ... 2018 , ... EDETEK, the premier provider of digital clinical trial platforms, today ... MD on October 8-12, 2018. EDETEK is also a Gold Sponsor of the Bay-area ... , CDISC Interchanges are global events held annually on three continents with hundreds of ...
(Date:10/5/2018)... SAN DIEGO (PRWEB) , ... October 04, 2018 , ... ... team-building cooking classes have become so popular. , Cooking appeals to companies ... such as group interaction, team cohesion, collaboration and decision-making skills. It’s also appealing ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... ... September 28, 2018 , ... ... to increase the availability of the GlycoMark test, the only FDA-cleared blood test ... the partnership, PMLS will promote and offer the GlycoMark test to its network ...
(Date:9/27/2018)... ... September 26, 2018 , ... NDA Partners Chairman ... quality, regulatory, and in vitro diagnostic device expert with more than 28 years ... the firm as an Expert Consultant. Her experience includes leadership roles in regulatory ...
(Date:9/27/2018)... ... September 26, 2018 , ... Medable was ... aims to build the first human digitome, a digital representation of human health ... a seamless integration of all data sources. Dr. Michelle Longmire, Co-Founder and CEO ...
(Date:9/27/2018)... ... 27, 2018 , ... This past weekend at the TB ... Inc. announced they will formally merge companies and integrate their technologies to create ... other diseases. These two social enterprise corporations, both of which focus heavily on ...
Breaking Biology Technology:
Cached News: