DNA to the defense

n to diversify its repertoire of VSG genes. Most of these genes are concentrated in subtelomeric regions, which in T. brucei, are hemizygous: only one copy of this region is present in the chromosome. In contrast, the gene-rich cores of T. brucei chromosomes are diploid, meaning that the standard two copies are present.

"The main observation from our work is that subtelomeres can dominate a chromosome to such an extent that a very small proportion of a chromosome is truly diploid," Melville explains. "These huge subtelomeres are largely non-coding DNA, yet they contain 'contingency genes' that the parasite multiplies and diversifies for future use."

In previous studies, Melville's group showed that trypanosome chromosomes were quite variable in size. "The range of size variation we observe in African trypanosomes far exceeds anything reported in other organisms to date," Melville says. "This, coupled with the potential size of the VSG repertoire in these huge subtelomeres suggests an unrivalled capacity for new immune-resistant strains of African trypanosomes."

Analysis of the genome sequence of T. brucei was published just last year, amid increasing calls for research into new control strategies for this neglected disease. The current study underscores this parasite's reputation as a master of adaptation, devoting unprecedented resources to avoiding immune attack. Since the VSG coat appears to prevent access to other non-variable parasite proteins, such capacity for variation further dims hopes for an effective vaccine for affected populations in rural Africa.


Contact: Maria Smit
Cold Spring Harbor Laboratory

Page: 1 2

Related biology news :

1. Rapid evolution of defense genes in plants may produce hybrid incompatibility
2. Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores
3. Research ends debate over benefits of butterfly defenses
4. On the defense: Conserved features of plant innate immunity
5. How plague-causing bacteria disarm host defense
6. Biodesign Institute takes part in $14.4M NIH chemical defense grant
7. Gene knockouts reveal FoxOs vital functions in cancer defense, health of stem cells
8. ASM Biodefense and Emerging Diseases Research Meeting
9. Molecular on/off switch controls immune defenses against viruses
10. Newly discovered immune defense may be impaired in CF airways
11. Counter defense strategy of virus

Post Your Comments:

(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... 2015 Munich, Germany ... technology (ASGM) automatically maps data from mobile eye tracking ... , so that they can be quantitatively analyzed with ... Munich, Germany , October 28-29, 2015. SMI,s Automated ... mobile eye tracking videos created with SMI,s Eye ...
(Date:10/26/2015)... , October 26, 2015 ... --> ReportnsReports.com adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> http://www.reportsnreports.com/reports/427352-biometrics-market-shares-market-strategies-and-market-forecasts-2015-to-2021.html ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( http://www.frost.com/sublib/display-report.do?id=P86A-01-00-00-00&src=PR ), finds that the market earned ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
Breaking Biology Technology:
Cached News: