HOME >> BIOLOGY >> NEWS
DNA to the defense

n to diversify its repertoire of VSG genes. Most of these genes are concentrated in subtelomeric regions, which in T. brucei, are hemizygous: only one copy of this region is present in the chromosome. In contrast, the gene-rich cores of T. brucei chromosomes are diploid, meaning that the standard two copies are present.

"The main observation from our work is that subtelomeres can dominate a chromosome to such an extent that a very small proportion of a chromosome is truly diploid," Melville explains. "These huge subtelomeres are largely non-coding DNA, yet they contain 'contingency genes' that the parasite multiplies and diversifies for future use."

In previous studies, Melville's group showed that trypanosome chromosomes were quite variable in size. "The range of size variation we observe in African trypanosomes far exceeds anything reported in other organisms to date," Melville says. "This, coupled with the potential size of the VSG repertoire in these huge subtelomeres suggests an unrivalled capacity for new immune-resistant strains of African trypanosomes."

Analysis of the genome sequence of T. brucei was published just last year, amid increasing calls for research into new control strategies for this neglected disease. The current study underscores this parasite's reputation as a master of adaptation, devoting unprecedented resources to avoiding immune attack. Since the VSG coat appears to prevent access to other non-variable parasite proteins, such capacity for variation further dims hopes for an effective vaccine for affected populations in rural Africa.


'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
3-Aug-2006


Page: 1 2

Related biology news :

1. Rapid evolution of defense genes in plants may produce hybrid incompatibility
2. Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores
3. Research ends debate over benefits of butterfly defenses
4. On the defense: Conserved features of plant innate immunity
5. How plague-causing bacteria disarm host defense
6. Biodesign Institute takes part in $14.4M NIH chemical defense grant
7. Gene knockouts reveal FoxOs vital functions in cancer defense, health of stem cells
8. ASM Biodefense and Emerging Diseases Research Meeting
9. Molecular on/off switch controls immune defenses against viruses
10. Newly discovered immune defense may be impaired in CF airways
11. Counter defense strategy of virus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
(Date:3/20/2017)... , March 20, 2017 At this year,s ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand ... is this year,s CeBIT partner country. At the largest German biometrics ... in use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics ... ...
(Date:3/13/2017)... Germany , March 13, 2017 Future of security: ... ... DERMALOGs Face Matching enables to match face ... forms the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... Franz ... Lisp (CL) development tools, and market leader for Semantic Graph Database ... now available within the most effective system for developing and deploying applications to ...
(Date:4/25/2017)... PROVIDENCE, R.I. , April 25, 2017 /PRNewswire/ ... EpiVax, Inc. ("EpiVax") has licensed its novel immune-modulating technology ... in autoimmune disease and allergy. Tregitopes, ... discovered in human immunoglobulin by EpiVax CEO ... Martin. Similar to intravenous immunoglobulin G, an autoimmune ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... Partners.     , Covalent’s Analytical Services unit provides high-quality data to clients, ... within 24 hours of receipt. There are no price premiums, and customers are ...
(Date:4/24/2017)... ... April 24, 2017 , ... It is well established that ... the broad application of this cellular target engagement concept to drug discovery has ... thermal stabilization assays are valuable methods for particular applications, but they can require ...
Breaking Biology Technology:
Cached News: