HOME >> BIOLOGY >> NEWS
DNA-wrapped carbon nanotubes serve as sensors in living cells

Single-walled carbon nanotubes wrapped with DNA can be placed inside living cells and detect trace amounts of harmful contaminants using near infrared light, report researchers at the University of Illinois at Urbana-Champaign. Their discovery opens the door to new types of optical sensors and biomarkers that exploit the unique properties of nanoparticles in living systems.

"This is the first nanotube-based sensor that can detect analytes at the subcellular level," said Michael Strano, a professor of chemical and biomolecular engineering at Illinois and corresponding author of a paper to appear in the Jan. 27 issue of the journal Science. "We also show for the first time that a subtle rearrangement of an adsorbed biomolecule can be directly detected by a carbon nanotube."

At the heart of the new detection system is the transition of DNA secondary structure from the native, right-handed "B" form to the alternate, left-handed "Z" form.

"We found that the thermodynamics that drive the switching back and forth between these two forms of DNA structure would modulate the electronic structure and optical emission of the carbon nanotube," said Strano, who is also a researcher at the Beckman Institute for Advanced Science and Technology and at the university's Micro and Nanotechnology Laboratory.

To make their sensors, the researchers begin by wrapping a piece of double-stranded DNA around the surface of a single-walled carbon nanotube, in much the same fashion as a telephone cord wraps around a pencil. The DNA starts out wrapping around the nanotube with a certain shape that is defined by the negative charges along its backbone.

When the DNA is exposed to ions of certain atoms -- such as calcium, mercury and sodium -- the negative charges become neutralized and the DNA changes shape in a similar manner to its natural shape-shift from the B form to Z form. This reduces the surface area covered by the DNA, perturbing the electronic s
'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
26-Jan-2006


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Experiment suggests limitations to carbon dioxide tree banking
3. Decoding mushrooms secrets could combat carbon, find better biofuels and safer soils
4. Scientists close in on missing carbon sink
5. Human activities increasing carbon sequestration in forests
6. Researchers examine carbon capture and storage to combat global warming
7. Soils offer new hope as carbon sink
8. Before selling carbon credits, read this
9. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
10. Seeing the trees for the forest: WHRC scientists creating national biomass and carbon dataset
11. Satellites play vital role in understanding the carbon cycle

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2020)... ... April 28, 2020 , ... Pebble Labs USA Inc. , a biotechnology ... aquaculture with the mission of improving global food security, announced today that they have ... Heroes in Food- and Ag-Tech ' virtual event, a global initiative to drive innovation ...
(Date:4/26/2020)... (PRWEB) , ... April 23, 2020 , ... A team ... GenScript, is developing a synthetic antibody to SARS-CoV-2, the virus that causes coronavirus disease ... and would be another potential treatment option for COVID-19. , The efforts are being ...
(Date:4/22/2020)... ... 21, 2020 , ... Worcester Polytechnic Institute (WPI) is expanding an existing science ... address the expected spike of COVID-19 cases. As part of its longtime Math and ... printers and other materials to be sent to six countries to facilitate the manufacturing ...
Breaking Biology News(10 mins):
(Date:4/1/2020)... ... March 30, 2020 , ... A joint venture between ... formed earlier this year to bring telehealth to various government agencies, has now ... Company officials are currently?awaiting an Emergency Use Authorization (EUA) waiver from the FDA?to?perform?AI?testing ...
(Date:4/1/2020)... Calif. (PRWEB) , ... March 31, 2020 , ... Carterra® ... Institute for Immunology (LJI), announced today that they will use Carterra’s proprietary LSA™ platform ... therapeutic candidates to the clinic as early as this summer. , La Jolla ...
(Date:3/27/2020)... ... March 25, 2020 , ... ... its veterinary histopathology laboratory located centrally in the midwest for high-quality, quick-turn, ... work with a highly motivated, independent, professional team that is focused on ...
(Date:3/19/2020)... Md. (PRWEB) , ... March ... ... a clinical supply and manufacturing collaboration agreement with pioneering gene circuit company ... cell therapies for ovarian cancer and other solid tumor indications. The collaboration ...
Breaking Biology Technology:
Cached News: