Damage to sperm DNA affects older men's chances of fathering children

Copenhagen, Denmark: Damage to DNA in sperm is significantly higher in older men than in those who are younger, according to research presented today (Tuesday 21 June 2005) at the 21st annual conference of the European Society of Human Reproduction and Embryology.

Dr. Sergey Moskovtsev, of the Mount Sinai Hospital, Toronto, Canada, told the conference that an increase in the average maternal and paternal ages at the time of attempted first pregnancy made this particularly significant. "Older men tend to reproduce with older women", he said, "and the combination of increased female factor infertility, increased sperm DNA damage, low levels of DNA repair, and increased abnormalities in conventional semen parameters present in this population will have a pronounced impact on their reproductive potential."

Dr. Moskovtsev and his team examined the relationship of DNA integrity, a novel semen parameter related to fertility potential, to age in 2134 men presenting for evaluation of their fertility. They identified damaged and normal sperm by means of a fluorescent dye that attaches to DNA, staining red when attached to damaged DNA and green to normal. Using 20 000 sperm per sample, they calculated DNA damage in each specimen via the ratio of red to green plus red. They found that DNA damage was significantly higher in men over 45 years old than in all younger age groups, and that the damage was doubled in those men 45 years and older compared with those less than 30 years old.

"Sperm DNA damage cannot be repaired", said Dr. Moskovtsev, "and appears to be a marker of reduced fertility potential rather than a predictor of fertility. Men with normal DNA integrity may be infertile for various reasons. We need to investigate the possibility of developing techniques to identify and select sperm without DNA damage for use in assisted reproduction techniques." IVF and ICSI cannot overcome abnormalities in DNA integrity, sa

Contact: Mary Rice
European Society for Human Reproduction and Embryology

Page: 1 2

Related biology news :

1. Damaged Iraq marshes show renewed signs of life
2. Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
3. First research to show that diabetes damages DNA in mens sperm and may affect fertility
4. Early-stage sperm cells created from human bone marrow
5. Maternal beef diet could impact sperm counts, UR study suggests
6. Link between beef consumption during pregnancy and reduced sperm quality in sons
7. Tracking sperm whales and jumbo squid
8. Rodent sperm work together for better results
9. Single molecular mark seen as pivotal for genome compaction in spores and sperm
10. Chromosomal abnormalities in sperm higher after vasectomy reversal
11. Study links high levels of nitric oxide to infertility and sperm DNA damage

Post Your Comments:

(Date:6/4/2019)... ... ... Harper was three years old when her owners took her to the veterinarian ... in the joints. She was referred to a veterinary specialist to perform “salvage ... Christopher Eich of Southern California Veterinary Specialty Hospital , examined Harper and recommended ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... Windows and mobile, announces the launch of version 13.1. The new version extends ... Management API, and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s ...
(Date:5/26/2019)... (PRWEB) , ... May 24, 2019 , ... Zolgensma (Novartis, ... as AVXS-101, was approved for clinical use in the United States by the Food ... virally-delivered gene therapy approved to treat inherited genetic disorders in the United States and ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... , ... June 11, 2019 , ... ... Personalized Stem Cells Inc. (PSC) , has announced that their GMP facility ... Food and Drug Branch for manufacturing. This is an important milestone for ...
(Date:6/6/2019)... ... 05, 2019 , ... WCCT Global, Inc ., a full-service early phase ... they will be receiving 3 awards at the 2019 CRO Leadership Awards, to be ... the categories of overall Quality and Compatibility (Access to desired markets, cultural fit, timely ...
(Date:5/31/2019)... Redwood City, California (PRWEB) , ... ... ... received allowance of our patent applications from the USPTO providing proprietary interest ... SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object ... announce the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the ... ownership and commercialization rights to a full spectrum of botulinum neurotoxins, as well ...
Breaking Biology Technology:
Cached News: