HOME >> BIOLOGY >> NEWS
Damage to sperm DNA affects older men's chances of fathering children

Copenhagen, Denmark: Damage to DNA in sperm is significantly higher in older men than in those who are younger, according to research presented today (Tuesday 21 June 2005) at the 21st annual conference of the European Society of Human Reproduction and Embryology.

Dr. Sergey Moskovtsev, of the Mount Sinai Hospital, Toronto, Canada, told the conference that an increase in the average maternal and paternal ages at the time of attempted first pregnancy made this particularly significant. "Older men tend to reproduce with older women", he said, "and the combination of increased female factor infertility, increased sperm DNA damage, low levels of DNA repair, and increased abnormalities in conventional semen parameters present in this population will have a pronounced impact on their reproductive potential."

Dr. Moskovtsev and his team examined the relationship of DNA integrity, a novel semen parameter related to fertility potential, to age in 2134 men presenting for evaluation of their fertility. They identified damaged and normal sperm by means of a fluorescent dye that attaches to DNA, staining red when attached to damaged DNA and green to normal. Using 20 000 sperm per sample, they calculated DNA damage in each specimen via the ratio of red to green plus red. They found that DNA damage was significantly higher in men over 45 years old than in all younger age groups, and that the damage was doubled in those men 45 years and older compared with those less than 30 years old.

"Sperm DNA damage cannot be repaired", said Dr. Moskovtsev, "and appears to be a marker of reduced fertility potential rather than a predictor of fertility. Men with normal DNA integrity may be infertile for various reasons. We need to investigate the possibility of developing techniques to identify and select sperm without DNA damage for use in assisted reproduction techniques." IVF and ICSI cannot overcome abnormalities in DNA integrity, sa
'"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
20-Jun-2005


Page: 1 2

Related biology news :

1. Damaged Iraq marshes show renewed signs of life
2. Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
3. First research to show that diabetes damages DNA in mens sperm and may affect fertility
4. Early-stage sperm cells created from human bone marrow
5. Maternal beef diet could impact sperm counts, UR study suggests
6. Link between beef consumption during pregnancy and reduced sperm quality in sons
7. Tracking sperm whales and jumbo squid
8. Rodent sperm work together for better results
9. Single molecular mark seen as pivotal for genome compaction in spores and sperm
10. Chromosomal abnormalities in sperm higher after vasectomy reversal
11. Study links high levels of nitric oxide to infertility and sperm DNA damage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/12/2019)... ... April 11, 2019 , ... Neal O’Farrell is one of the first ... He is executive director of the consumer advocacy non-profit the Identity Theft Council as ... member of the Federal Communications Commission’s Cybersecurity Roundtable and is currently a fellow of ...
(Date:4/9/2019)... ... April 09, 2019 , ... The McLeod Center ... Center following a rigorous and voluntary audit conducted by an independent, third-party panel ... eight Novalis Certified Centers in the United States, McLeod is the only such cancer ...
(Date:4/4/2019)... (PRWEB) , ... April 02, 2019 , ... ... 23, 2019 at 1pm EDT will provide insight into the connectivity between product ... the use of eClinical platforms in supporting this process. , With increasing global ...
Breaking Biology News(10 mins):
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National ... on the importance of healthy meals and good nutrition. This month, Chef Jodi ... Bank’s volunteer chef. , The first segment addressed the nutritional value of ...
(Date:3/19/2019)... , ... March 19, 2019 , ... The AACR annual ... great opportunity to see the most cutting-edge cancer research. The Visikol team will be ... 3D cell culture assays as well as their digital pathology services . ...
(Date:3/19/2019)... , ... March 19, 2019 , ... This free webinar will review strategies ... , Learn how to reduce study build times by up to 30 percent, reducing ... cloud platform enables mid-study changes without the need to migrate data – reducing risk and ...
(Date:3/15/2019)... ... March 15, 2019 , ... ... Inc. and affiliate companies including AVAPCO LLC and API Intellectual Properties Holdings. ... Biorefinery and R&D center in Thomaston, Georgia, operations, research, and business development ...
Breaking Biology Technology:
Cached News: