Dana Farber and 454 life sciences announce breakthrough in DNA sequencing for cancer research

BRANFORD, Conn. June 25, 2006 454 Life Sciences Corporation, a majority-owned subsidiary of CuraGen Corporation (Nasdaq: CRGN), in collaboration with scientists at Dana Farber Cancer Center and Broad Institute, today reported a new method for the detection of cancer gene mutations present at extremely low levels. The research, published online (ahead of print) in the journal Nature Medicine, describes how the 454 SequencingTM method identifies rare cancer-associated genetic variations at the molecular level, potentially enabling the personalization of targeted therapies.

454 SequencingTM technology was used to analyze mutations in five exons of the Epidermal Growth Factor Receptor (EGFR) gene in tumor samples from 22 patients with lung cancer. The EGFR gene is the target for several new anti-cancer drugs called EGFR inhibitors. This research proposes that 454 SequencingTM may help to validate the ability of EGFR mutations to predict patient responsiveness to treatment with an EGFR inhibitor.

It has been realized that genetic mutations are responsible for sensitizing some tumor cells to chemotherapy, while other mutations render tumor cells completely resistant to drug treatments. Historically, research progress has been slowed by the complex mix of cells in a tumor sample, compounded by cost-prohibitive, conventional low-resolution sequencing methods that lack sufficient accuracy to characterize the DNA in cancerous cells. 454 SequencingTM is the first advanced sequencing technology that can generate hundreds of thousands of DNA sequences in one run, rapidly and comprehensively conducting high-throughput nucleotide sequencing, with specific application to sequencing of whole genomes and ultra-deep sequencing of target genes. By enabling a method of sequencing that is more comprehensive and less expensive than conventional sequencing methods, 454 SequencingTM may be us

Contact: Benjamin Carmichael
Noonan/Russo Communications

Page: 1 2

Related biology news :

1. Neurosciences and music meet in Montreal
2. Nottingham biosciences million pound injection
3. New perspectives for the geosciences and climate research
4. Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences
5. InfoSNM highlights advances in computer, information sciences for molecular imaging
6. Malaria in pregnancy: What can the social sciences contribute?
7. AIBS honors outstanding contributions to the biological sciences
8. Protein sciences
9. Powerful ally in life sciences: UH research head to give keynote
10. Brave new world in life sciences
11. NIEHS Director unveils new strategic plan for environmental health sciences

Post Your Comments:

(Date:7/4/2020)... ... 2020 , ... Aesthetics Biomedical (ABM), a leading aesthetics product ... only the products and treatments developed, but also the dedicated team behind the ... brands built by ABM have received several honors already for 2020, each of ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global leader in ... Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of Japan. , ... Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode ... in accelerated Point of Care Testing solutions (POCT). Check local listings for more info. ... at medical offices and are shipped to labs throughout the country. Results are then ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a ... has closed on the purchase of greenfield for a new, expanded manufacturing facility. ... over 21 acres in the initial acquisition, with an option to purchase an ...
(Date:7/31/2020)... ... 29, 2020 , ... Diversified Technologies, Inc. has introduced a ... to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter Systems ... a push-pull configuration; yielding fast fall time for a capacitive load. These all ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... for the life sciences industry, today announced the release of its signature ... for Medical Science Liaisons (MSLs) and other field medical professionals. , ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a leading ... food industries, is pleased to announce that Charles Galea has joined its clinical ... Charles is an accomplished and results-driven sales executive with over 10 years of ...
Breaking Biology Technology:
Cached News: