HOME >> BIOLOGY >> NEWS
Dartmouth, GlycoFi researchers make leap in protein bioengineering

Investigators at Dartmouth's Thayer School of Engineering, the Dartmouth-Hitchcock Medical Center, and the biotechnology firm GlycoFi, Inc., report a breakthrough in using yeast to produce antibodies with human sugar structures.

Antibodies are proteins with sugars attached to them, and they are emerging as a major class of drugs in the treatment of cancer. In the global effort to increase the potency of antibodies, the interdisciplinary work by the Dartmouth/GlycoFi team, published in the February issue of Nature Biotechnology, represents a major advance. The work shows that antibodies with increased cancer-killing ability can be produced by controlling the sugar structures that are attached to them.

"This work demonstrates, for the first time, that an antibody with human sugar structures can be produced in a non-mammalian host," says Tillman Gerngross, GlycoFi's Chief Scientific Officer and professor of engineering at Dartmouth's Thayer School.

Huijuan Li, the Associate Director of Analytical Development at GlycoFi and the lead author on the study, adds, "By controlling the sugar structures on antibodies we have shown that the antibodies ability to kill cancer cells can be significantly improved and that proteins can be optimized by controlling their sugar structures."

While the current report focuses on antibodies, the approach taken by the GlycoFi team can be applied to any therapeutic glycoprotein. Currently glycoproteins comprise about 70 percent of all approved therapeutic proteins and the therapeutic protein market is expected to grow at over 20 percent annually over the next decade, according to the researchers.

"GlycoFi is the world leader in protein glyco-engineering, and this work is an example of the exciting translational research that has been spun out of Dartmouth," says Gerngross.


'"/>

Contact: Sue Knapp
Sue.Knapp@Dartmouth.edu
603-646-3661
Dartmouth College
22-Jan-2006


Page: 1

Related biology news :

1. Dartmouth and GlycoFi report full humanization of therapeutic proteins from yeast
2. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
3. GlycoFi announces the first production of antibodies with human glycosylation in yeast
4. Innovative tagging technique may help researchers better protect fish stocks
5. Penn researchers discover how key protein stops inflammation
6. ASU researchers partner with UOP to make biofuel for military jets a reality
7. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. U-M researchers find family of on switches that cause prostate cancer
10. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
11. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2017)... VIEW, Calif. , March 9, 2017 ... 23andMe , the leading personal genetics company, are using ... now provide customers with personalized nutrition plans that consider ... but also genetic markers impacting how their body may ... food decision support platform uses biometrics such as Body ...
(Date:3/7/2017)... , March 7, 2017   HireVue , the ... global companies identify the best talent, faster, today announced ... Sales Officer (CSO) and Diana Kucer as ... out a seasoned executive team poised to drive continued growth ... on a year of record bookings in 2017. ...
(Date:3/2/2017)... -- Summary This report provides all the information ... and activities since 2010. ... Read the full report: http://www.reportlinker.com/p03605615-summary/view-report.html ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... Looking ... team-building and cooking events company, offers one-of-a-kind gifts, ranging from gourmet cooking experiences ... California cuisine, and guests leave inspired with new cooking tips and techniques, thanks ...
(Date:4/26/2017)... Palo Alto, CA, USA (PRWEB) , ... April ... ... ComplianceOnline’s popular seminar on FDA’s GMP expectations for phase I clinical trials comes ... was attended by various biotechnology and pharma professionals representing FDA regulated organizations such ...
(Date:4/26/2017)... ... 26, 2017 , ... Baltimore bio tech firm, PathSensors, Inc., ... solution at the National Postal Forum 2017 in Baltimore, Maryland, May 21st through ... easy to use and low cost threat detection solution for government and commercial ...
(Date:4/26/2017)... RESTON, Va. (PRWEB) , ... April 26, 2017 ... ... to make headlines and drive high-level conversations among healthcare industry stakeholders, the discussion ... Healthcare Environment – taking place May 15-18, 2017 in Los Angeles, Calif. Hosted ...
Breaking Biology Technology:
Cached News: