HOME >> BIOLOGY >> NEWS
Dartmouth, GlycoFi researchers make leap in protein bioengineering

Investigators at Dartmouth's Thayer School of Engineering, the Dartmouth-Hitchcock Medical Center, and the biotechnology firm GlycoFi, Inc., report a breakthrough in using yeast to produce antibodies with human sugar structures.

Antibodies are proteins with sugars attached to them, and they are emerging as a major class of drugs in the treatment of cancer. In the global effort to increase the potency of antibodies, the interdisciplinary work by the Dartmouth/GlycoFi team, published in the February issue of Nature Biotechnology, represents a major advance. The work shows that antibodies with increased cancer-killing ability can be produced by controlling the sugar structures that are attached to them.

"This work demonstrates, for the first time, that an antibody with human sugar structures can be produced in a non-mammalian host," says Tillman Gerngross, GlycoFi's Chief Scientific Officer and professor of engineering at Dartmouth's Thayer School.

Huijuan Li, the Associate Director of Analytical Development at GlycoFi and the lead author on the study, adds, "By controlling the sugar structures on antibodies we have shown that the antibodies ability to kill cancer cells can be significantly improved and that proteins can be optimized by controlling their sugar structures."

While the current report focuses on antibodies, the approach taken by the GlycoFi team can be applied to any therapeutic glycoprotein. Currently glycoproteins comprise about 70 percent of all approved therapeutic proteins and the therapeutic protein market is expected to grow at over 20 percent annually over the next decade, according to the researchers.

"GlycoFi is the world leader in protein glyco-engineering, and this work is an example of the exciting translational research that has been spun out of Dartmouth," says Gerngross.


'"/>

Contact: Sue Knapp
Sue.Knapp@Dartmouth.edu
603-646-3661
Dartmouth College
22-Jan-2006


Page: 1

Related biology news :

1. Dartmouth and GlycoFi report full humanization of therapeutic proteins from yeast
2. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
3. GlycoFi announces the first production of antibodies with human glycosylation in yeast
4. Innovative tagging technique may help researchers better protect fish stocks
5. Penn researchers discover how key protein stops inflammation
6. ASU researchers partner with UOP to make biofuel for military jets a reality
7. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. U-M researchers find family of on switches that cause prostate cancer
10. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
11. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate

Post Your Comments:
(Date:5/22/2015)... 2015 According to a new ... 3D, Thermal, Emotion, Forensic), by Software (Middleware, Databases), by Hardware ... Consumer and Home) - Global Forecast to 2020", published ... Billion in 2015 to $6.19 Billion by 2020, at ... market data Tables and   43 Figures spread through ...
(Date:5/21/2015)... The Sync Project™ , a global ... today announced a collaborative partnership with Berklee,s Institute ... on collaboration on original research, joint course development and ... collaboration, The Sync Project and BerkleeICE are exploring the ... the 2015-2016 academic year.  The course ...
(Date:5/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... 3D-ID LLC, a company engaged in biometric identification is ... technology portion of the recently awarded TIES (Technical Information ... the Army. 3D-ID LLC has a suite ... enforcement and security agencies. Gino Pereira ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3
(Date:5/21/2015)... May 21, 2015 Tunnell Consulting, ... the firm as senior statistician and Principal, a position ... experience in the management and analysis of complex and ... chemical industries. , “We’re delighted to have Julia join ... data analytics,” said Dr. Philippe Cini, Group Vice President ...
(Date:5/20/2015)... MECHANICSBURG, Pa. , May 20, 2015 /PRNewswire/ ... announced that the Federal Trade Commission granted early ... (HSR) Antitrust Improvements Act of 1976, as amended, ... by MJ Acquisition Corporation, a joint venture that ... XII, L.P. As previously announced, MJ ...
(Date:5/20/2015)... -- Haemonetics Corporation (NYSE: HAE ) announced today that ... at The Jefferies 2015 Global Healthcare Conference in ... , 2015 at 8:30am Eastern time.  ... webcast at: http://wsw.com/webcast/jeff88/hae ... a global healthcare company dedicated to providing innovative blood ...
(Date:5/20/2015)... (PRWEB) May 20, 2015 Optivia ... assay services for Drug-Drug Interactions (DDI), Metabolism and ... a world leader in assessing impact of drugs ... Pharmacology supported by biosimulation, announced today that they ... allows both companies to expand their product and ...
Breaking Biology Technology:Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 3
Cached News: