Dartmouth, GlycoFi researchers make leap in protein bioengineering

Investigators at Dartmouth's Thayer School of Engineering, the Dartmouth-Hitchcock Medical Center, and the biotechnology firm GlycoFi, Inc., report a breakthrough in using yeast to produce antibodies with human sugar structures.

Antibodies are proteins with sugars attached to them, and they are emerging as a major class of drugs in the treatment of cancer. In the global effort to increase the potency of antibodies, the interdisciplinary work by the Dartmouth/GlycoFi team, published in the February issue of Nature Biotechnology, represents a major advance. The work shows that antibodies with increased cancer-killing ability can be produced by controlling the sugar structures that are attached to them.

"This work demonstrates, for the first time, that an antibody with human sugar structures can be produced in a non-mammalian host," says Tillman Gerngross, GlycoFi's Chief Scientific Officer and professor of engineering at Dartmouth's Thayer School.

Huijuan Li, the Associate Director of Analytical Development at GlycoFi and the lead author on the study, adds, "By controlling the sugar structures on antibodies we have shown that the antibodies ability to kill cancer cells can be significantly improved and that proteins can be optimized by controlling their sugar structures."

While the current report focuses on antibodies, the approach taken by the GlycoFi team can be applied to any therapeutic glycoprotein. Currently glycoproteins comprise about 70 percent of all approved therapeutic proteins and the therapeutic protein market is expected to grow at over 20 percent annually over the next decade, according to the researchers.

"GlycoFi is the world leader in protein glyco-engineering, and this work is an example of the exciting translational research that has been spun out of Dartmouth," says Gerngross.


Contact: Sue Knapp
Dartmouth College

Page: 1

Related biology news :

1. Dartmouth and GlycoFi report full humanization of therapeutic proteins from yeast
2. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
3. GlycoFi announces the first production of antibodies with human glycosylation in yeast
4. Innovative tagging technique may help researchers better protect fish stocks
5. Penn researchers discover how key protein stops inflammation
6. ASU researchers partner with UOP to make biofuel for military jets a reality
7. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. U-M researchers find family of on switches that cause prostate cancer
10. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
11. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate

Post Your Comments:

(Date:10/29/2015)... Oct. 29, 2015 Daon, a global leader ... has released a new version of its IdentityX ... North America have already installed IdentityX ... includes a FIDO UAF certified server component ... to activate FIDO features. These customers include some of ...
(Date:10/27/2015)... 27, 2015 In the present market scenario, ... for various industry verticals such as banking, healthcare, defense, ... growing demand for secure & simplified access control and ... as hacking of bank accounts, misuse of users, , ... as PC,s, laptops, and smartphones are expected to provide ...
(Date:10/26/2015)... NEWARK, Calif. , Oct. 26, 2015  Delta ... convenient biometric authentication to mobile and PC devices, announced ... Fujitsu,s smartphone, the arrows NX F-02H launched by NTT ... arrows NX F-02H is the second smartphone to include ... this technology in ARROWS NX F-04G in May 2015, ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... 2015 --> ... companion diagnostics is one of the major ... pharmaceutical companies and diagnostic manufacturers working together ... http://www.rnrmarketresearch.com/global-cancer-biomarkers-market-2015-2019-market-report.html . --> http://www.rnrmarketresearch.com/global-cancer-biomarkers-market-2015-2019-market-report.html ... global cancer biomarkers market spread across 89 ...
(Date:11/25/2015)... 26, 2015 --> ... 2016 - 2020 report analyzes that automating biobanking ... quality in long-term samples, minimizing manual errors, improving ... minimizes manual errors such as mislabeling or inaccurate ... it plays a vital role in blood fractionation, ...
(Date:11/25/2015)... Studies reveal the differences in ... pave the way for more effective treatment for one of ...   --> --> Gum ... in cats, yet relatively little was understood about the bacteria ... been conducted by researchers from the WALTHAM Centre for Pet ...
(Date:11/25/2015)... QUEBEC CITY , Nov. 25, 2015 /PRNewswire/ ... "Company"), affirms that its business and prospects remain ... , Zoptrex™ (zoptarelin doxorubicin) recently received DSMB ... program to completion following review of the final ... met Phase 2 Primary Endpoint in men with ...
Breaking Biology Technology:
Cached News: