HOME >> BIOLOGY >> NEWS
Dartmouth researchers identify a gene that enhances muscle performance

A team of researchers, led by scientists at Dartmouth Medical School and Dartmouth College, have identified and tested a gene that dramatically alters both muscle metabolism and performance. The researchers say that this finding could someday lead to treatment for muscle diseases, including helping the elderly who suffer from muscle deterioration and improving muscle performance in endurance athletes.

The researchers report that the enzyme called AMP-activated protein kinase (or AMPK) is directly involved in optimizing muscle activity. The team bred a mouse that genetically expressed AMPK in an activated state. Like a trained athlete, this mouse enjoyed increased capacity to exercise, manifested by its ability to run three times longer than a normal mouse before exhaustion. One particularly striking feature of the finding was the accumulation of muscle glycogen, the stored form of carbohydrates, a condition that many athletes seek by "carbo-loading" before an event or game. The study appears in the Nov. 14 online issue of the American Journal of Physiology: Endocrinology and Metabolism.

"Our genetically altered mouse appears to have already been an exercise program," says Lee Witters, the Eugene W. Leonard 1921 Professor of Medicine and Biochemistry at Dartmouth Medical School and professor of biological sciences at Dartmouth College. "In other words, without a prior exercise regimen, the mouse developed many of the muscle features that would only be observed after a period of exercise training."

Witters, whose lab led the study, explains that this finding has implication for anyone with a muscle disease and especially for the growing proportion of the population that is aging. Deteriorating muscles often make the elderly much more prone to fall, leading to hip and other fractures. According to Witters, there is tremendous interest in the geriatric field to find ways to improve muscle performance.

"We now wonder if it's pos
'"/>

Contact: Sue Knapp
sue.knapp@dartmouth.edu
603-646-3661
Dartmouth College
15-Nov-2006


Page: 1 2

Related biology news :

1. Dartmouth professor makes case for ethically universal stem cell lines
2. Plants that produce more vitamin C may result from UCLA-Dartmouth discovery
3. Vitamin extends life in yeast, Dartmouth Medical School researchers find
4. Dartmouth researchers find that arsenic triggers unique mechanism in rare leukemia
5. Dartmouth researchers find that low doses of arsenic have broad impact on hormone activity
6. Dartmouth study contributes to research addressing malnutrition and iron deficiency
7. Genetic variation impacts aspirins effectiveness in preventing colon cancer, Dartmouth study finds
8. Dartmouth researchers find a neural signature of bilingualism
9. Dartmouth and GlycoFi report full humanization of therapeutic proteins from yeast
10. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
11. Dartmouth researchers find key player in immune system regulation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... ... ... Greffex, a pioneering vaccine and gene therapy company based in Houston, Texas, welcomes ... a global perspective to make an impact in a post pandemic world,” said Co-Chairman ... independent, director of the company. , “The Greffex board is excited to have Neil ...
(Date:5/30/2020)... ... May 29, 2020 , ... eInfochips, a leading provider of ... with EchoNous Inc. to develop the cloud-based connected health KOSMOS platform that has ... has been clinically tested versus expert measurements, yielding improved results in precision and ...
(Date:5/28/2020)... (PRWEB) , ... May 27, 2020 , ... ... hc1 Workforce Advisor™ , a solution that uniquely combines lab testing insights ... help employers systematically support the ongoing health and safety of employees returning to ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 30, 2020 , ... ... that the launch of a new clinical diagnostics immuno-oncology service, TissueInsight ... microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, ...
(Date:6/23/2020)... ... 23, 2020 , ... Kerafast Inc. , developers of ... the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, ... SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) ...
(Date:6/19/2020)... ... , ... The Vitaspace project was founded by the famous Russian ... life and find a way (medicine or technology) that will help to preserve youth, ... scientists from all over the world, doctors, and all people who care. , The ...
(Date:6/3/2020)... MONTREAL (PRWEB) , ... June 03, 2020 , ... ... designed to highlight various applications of biofeedback. In the next installment, Dr. Inna ... a practice whereby individuals learn to bring their attention to the feelings, thoughts, ...
Breaking Biology Technology:
Cached News: