HOME >> BIOLOGY >> NEWS
Data presented at ISHLT meeting confirm RNA analysis can identify rejection in lung transplant recip

SAN FRANCISCO, April 27, 2007 Recent data from the Lung Allograft Rejection Gene expression Observational (LARGO) study provides compelling evidence that profiling gene expression in peripheral blood can detect organ rejection in lung transplant patients. Refining the Identification of Discriminatory Genes for Rejection in Lung Transplantation: The LARGO Study will be presented today by Shaf Keshavjee, M.D., Chair, Division of Thoracic Surgery, University of Toronto, and LARGO study lead, at the 27th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT).

Data from the study (Abstract 351) shows that the immune responses of lung transplant recipients can result in novel molecular signatures identifying the absence or presence of acute cellular rejection (ACR). That molecular signature can be identified using the quantitative real-time polymerase chain reaction (RT-PCR), a technology that measures the intracellular RNA levels of individual genes.

By distinguishing the patterns of gene expression in white blood cells (leukocytes), which fluctuate during the rejection of foreign tissue, PCR-based gene profiling can identify individual genes and pathways associated with the rejection status of transplanted lungs. In addition, the study shows that some of the genes whose expression changes during rejection of a transplanted lung are the same as those whose expression changes during the rejection of a transplanted heart.

Using microarray analysis, the researchers identified 259 genes that were differentially expressed for A0 and >A2 rejection grades (based on a standardized severity scale of 0-4). RT-PCR confirmed 14 of these genes as candidates for analysis, revealing a high correlation with those identified using microarray analysis. Seven of those genes were considered statistically significant.

"We are excited to confirm that new monitoring methods, such as non-invasi
'"/>

Contact: Margaret Clark
mclark@masonpr.com
210-857-2521
International Society for Heart and Lung Transplantation
27-Apr-2007


Page: 1 2

Related biology news :

1. Clinical trial data regarding NKTR-061 will be presented at ATS International Conference
2. Latest plant health research to be presented in San Diego
3. Presidential Recognition Awards presented at the 2007 AIUM Annual Convention
4. Soliris (eculizumab) data to be presented at American Society of Hematology
5. Agronomy, crop, soils research presented in Indianapolis
6. UW-Madison work on stem cells, cardiac health to be presented at ACS
7. Weizmann Women & Science Award presented to Dr. Mary-Claire King
8. IOF-Novartis Young Scholars Awards presented to seven researchers from six countries
9. Coma misrepresented in movies
10. Latest plant disease research to be presented in Quebec City
11. AIUM Presidential Recognition Awards presented

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/18/2019)... ... December 17, 2019 , ... Mitotech S.A, a Luxembourg-based clinical-stage ... its U.S. Phase 3 study VISTA-2 building on positive results of VISTA-1 clinical ... to severe Dry Eye Disease (DED). SkQ1 belongs to the class of cardiolipin ...
(Date:12/18/2019)... SEATTLE (PRWEB) , ... December 18, 2019 , ... ... higher education planning, has announced the Top 10 Master's in Biotechnology Degree Programs ... accredited colleges and universities in the nation. Each program is evaluated based on ...
(Date:12/14/2019)... ... 12, 2019 , ... Crop Enhancement Inc., an ... Jean Pougnier as chief business officer. Mr. Pougnier will lead the company’s efforts ... will position the company for maximum commercial success. As part of the expansion ...
Breaking Biology News(10 mins):
(Date:1/7/2020)... (PRWEB) , ... January 06, 2020 , ... ... a Digital World at The Fletcher School at Tufts University, is pleased to ... Foundation. The grant will be administered by Tufts University, and will help to ...
(Date:12/31/2019)... ... December 31, 2019 , ... Vici ... development lab in Maryland. Emphasis will be in expanding capabilities in ... Vici Health Sciences will be well positioned to meet the growing demand for ...
(Date:12/27/2019)... HARBOR TOWNSHIP, N.J. (PRWEB) , ... December 27, ... ... manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical ... first calendar year under new management . Following acquisition by CLJ Holdings ...
(Date:12/18/2019)... ... December 17, 2019 , ... Innovative Health, Inc. ... Electrophysiology (EP) devices since the company’s inception in 2016. This marks a record ... Johnson & Johnson company) have received 2 and 4 EP device clearances, respectively, ...
Breaking Biology Technology:
Cached News: