HOME >> BIOLOGY >> NEWS
Deciphering the genetic babel of brain cells

Gene chips, or microarrays, have proven to be immensely important in measuring the activity of thousands of genes at once in such cells as cancer cells or immune cells. The use of these chips has given scientists snapshots of gene activity that lead to better understanding of the genetic machinery of the cells. This understanding has led to new ways to kill cancers or to manipulate the immune system, for example.

Gene chips consist of vast arrays of thousands of specific genetic segments spotted onto tiny chips. When gene extracts of cells are applied to the chips, labeled with fluorescent indicators, genes from the cell extracts attach to their complementary counterparts on the chips. Measurements of the fluorescence of each spot give scientists an indication of the activity of particular genes.

As vital as they are to studies of individual types of cells, gene chips have proven to be less useful in efforts to understand the genetic signatures of specific brain cells, because a myriad of subtly different subtypes of brain cells are intertwined in brain tissue.

Now, however, researchers led by Jeffrey Macklis, Bradley Molyneaux, and Paola Arlotta of the MGH-HMS Center for Nervous System Repair at Harvard Medical School and Massachusetts General Hospital and Harvard Stem Cell Institute have developed a way to distinguish particular brain cell subtypes in tissue and to separate them for genetic analysis with microarrays. Their technique will prove enormously helpful to neuroscientists studying the development and function of the brain. For example, it will enable researchers to genetically tag, manipulate, and even knock out the function of specific subtypes of neurons to study their function. Also, by comparing genetic profiles of cells in normal and diseased brains, researchers can gain invaluable clues to the origins of neurological disorders.

In their technique, the scientists first labeled a specific brain cell in living brain tiss
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
19-Jan-2005


Page: 1 2 3

Related biology news :

1. Deciphering the Arctic Ocean climate puzzle
2. Deciphering an autism mystery
3. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
4. Does the desire to consume alcohol and tobacco come from our genetic makeup?
5. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
6. Penn researchers discover pathway that eliminates genetic defects in red blood cells
7. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
8. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
9. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
10. Identified main genetic variants involved in response to HIV
11. Restless legs genetics on the move

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... ... June 04, 2020 , ... Murrieta Genomics has announced that its ... simplified sample preparation for Next Generation Genomic Sequencing (NGS) . This is the ... complexity of sample preparation. , “I have been at the bench for over 20 ...
(Date:6/5/2020)... ... 04, 2020 , ... Greffex, a pioneering vaccine and gene therapy company based ... understands the need for a global perspective to make an impact in a post ... will serve as an independent, director of the company. , “The Greffex board is ...
(Date:5/30/2020)... Calif. (PRWEB) , ... May 29, 2020 , ... ... enabler of digital transformation for enterprises globally, has collaborated with EchoNous Inc. to ... FDA. It can measure systolic heart function, which has been clinically tested ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... The SDX® Respiratory Gating System ... has reached its 20th anniversary of worldwide use. Introduced in the US over ... including University of Pennsylvania, University of Michigan, University of Maryland, University of California ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... aid in the early detection and prevention of high-burden diseases, and Centric Consulting, ... hospitals and healthcare organizations to utilize existing data in order to identify and ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... today announced that the launch of a new clinical diagnostics immuno-oncology ... the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that aids ...
Breaking Biology Technology:
Cached News: