The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Decoding gene expression in cancer tumors using noninvasive imaging

By correlating images of cancerous liver tissue with gene expression patterns, a research team led by a radiologist at the University of California, San Diego (UCSD) School of Medicine has developed tools that may some day allow physicians to view a CT image of a cancer tumor and discern its genetic activity. The study, designed to help doctors obtain the molecular details of a specific tumor or disease without having to do an invasive biopsy procedure, will be published online on May 21 in Nature Biotechnology.

According to principle investigator Michael Kuo, M.D., assistant professor of interventional radiology at UCSD, the study represents the convergence of two developing fields of medical research: the mapping of the human genome and advances in diagnostic imaging.

The research team, which included investigators from Stanford University School of Medicine, systematically compared features from CT images of liver tumors with gene expression patterns obtained from surgery and tissue biopsies. Once they pinpointed the genomic correlates of the features detected by CT imaging, the researchers found that the two very different aspects of studying cancer how the tumor looks in a CT scan and how it behaves on a molecular level had a very strong connection.

"We studied what the various genes were doing and the biological activity they were involved in such as angiogenesis or cell growth. We also looked at how the genes contributed to a particular phenotype in the liver tumor seen on the CT scans, for example, the presence of characteristics vessels, or the tumor's texture and other important diagnostic imaging traits," said Kuo.

The research process sought to reveal the relationship between genetic activity patterns in liver tumors and the tumor's appearance on CT scans, and provide a simple means of translation. The scientists initially began with approximately 135 basic tumor descriptors, and then narrowed down th
'"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
21-May-2007


Page: 1 2 3

Related biology news :

1. Decoding mushrooms secrets could combat carbon, find better biofuels and safer soils
2. Decoding protein structures helps illuminate cause of diabetes
3. Decoding the logic of olfaction
4. A low expression of MX2 gene exists in the white blood cells of narcoleptics
5. Gene expression pattern could lead to improved treatment of pediatric septic shock
6. Boston Univeristy bioengineers devise dimmer swith to regulate gene expression in mammal cells
7. Clocking in and out of gene expression
8. High cholesterol diets modify gene expression in atherosclerosis
9. Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
10. Growing nerve cells in 3-D dramatically affects gene expression
11. XDx to present recent success with AlloMap molecular expression testing

Post Your Comments:
(Date:11/24/2009)... 24, 2009) New research on bacterial communities ...ls predictable temporal patterns, suggesting that ...for monitoring climate change in the polar regions...gs of the National Academy of Sciences Early Edit...ivers shifted synchronously over time, correlating...
(Date:11/23/2009)...vember 23, 2009 Applied mathematicians dissected ...olia ), a characteristic long leaf with a saddle-l...g the edges. The simple cause of the lily,s fan-li...during differential growthwas revealed by using an.... , Haiyi Liang, a postdoctoral student at Harva...
(Date:11/23/2009)...research suggests that a common oral bacterium may...t by Nichols et al, "Unique Lipids from a Common H...ds Capable of Enhancing Autoimmunity," appears in ...f Pathology . , Multiple sclerosis (MS), a disea...pinal cord, affects nearly 1 in 700 people in the ...
Breaking Biology News(10 mins):Researchers establish common seasonal pattern among bacterial communities in Arctic rivers 2The cause behind the characteristic shape of a long leaf revealed 2Factors from common human bacteria may trigger multiple sclerosis 2Killing cancer like a vampire slayer 57532 1Killing cancer like a vampire slayer 57532 2Proposal to reintroduce Iberian lynx on abandoned agricultural land 57527 1Proposal to reintroduce Iberian lynx on abandoned agricultural land 57527 2Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals 9967 1Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals 9967 2Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals 9967 3
(Date:11/24/2009)... SEATTLE,Nov.24/PRNewswire-FirstCall/--CellTherape...esentatthe21stAnnualPiperJaffrayHealthCareConferen...wYorkPalaceHotel. ,, CTIwillpresentonTuesday,De...liveaudiowebcastofCTI,spresentationwillbeavailable...bleforreplayafterwards. , ,PiperJaffrayHealthCare...
(Date:11/23/2009)...ene consists of a two-dimensional carbon layer in ... lattice, resembling a honeycomb. Carbon nanotubes... of graphene sheets form graphite. Graphene boasts...y tear-resistant, an excellent thermal conductor, ...leness and ductility. In addition, graphene is imp...
(Date:11/23/2009)... Contec’s Sporicidin disin...ive hospital-grade disinfectants against H1N1 and ...rg, SC (PRWEB) November 24, 2009 -- Contec Inc, th...as announced that their Sporicidin disinfectants ...all Influenza A viruses, including Pandemic 2009 H...
(Date:11/23/2009)... REDWOODCITY,Calif.,Nov.23/PRNewswire/--PearlThera...rapeuticproductsforthetreatmentofchronicrespirator...tothecompany,sBoardofDirectors.Mr.Rosenhas25yearso...stries,includingkeyrolesatGileadSciencesandALZACor...rsonPearl,sBoardtosix. ,, "Howiebringsawealthof...
Breaking Biology Technology:Polymer with honeycomb structure 2Sporicidin Brand Disinfectant Kills H1N1 in 3 Minutes 2Pearl Therapeutics Appoints Howie Rosen to Board of Directors 2
Other News:
...s shown that the development of permanent resistan...t be prevented in the longer-term. The only soluti...sing these less. ......The reduced effectiveness o...uman health. For example, plants can have a gene i...
...s week's issue of THE LANCET provides further evid...g a functional immune system for infants with seve...a genetic disease which prevents the immune system...ning. This leaves individuals at high risk of infe...
People screened for genetic disorders must have appropriate follow-up and monitoring to avoid stress and anxiety, according to new research sponsored by the ESRC. ......Those with a condition may also
... we ready for a future where brain scans invade ou...ns chemically to keep competitive at our jobs? Co...nd, if so, what does that mean for how we think of...n this month's edition of the journal Trends in Co...
Permanent resistance to antibiotics cannot be prevented 2Screening for genetic disorders: Need to avoid anxiety 2Your brain and you: Forecasting the ethical challenges ahead for neuroscience and society 2Your brain and you: Forecasting the ethical challenges ahead for neuroscience and society 3
...TAN, Kan. -- Kansas State University is one of sev...million federal grant to study how plants respond ...thways underlying their responses evolve in differ...f the premier labs in the world on this project, w...
...earch reported this month in The Plant Cell, scien...linseed plants that accumulate significant levels ...UFA) in seed. This is the first report of the succ... oilseed crop, and is an excellent example of how ...
...p from the Salk institute illuminates the structur...ynthase, the enzyme that produces resveratrol, the... ...Plant natural products called stilbenes can c...e been shown to possess health benefits for humans...
...strategy for cancer therapy, which converts the tu...matory response into a cancer-killing outcome, is ... the University of California, San Diego (UCSD) Sc...sight into the immune system's response to inflamm...
K-State, other universities to study how climate affects plant evolution 2Genetic modification of linseed produces healthier omega 3 and 6 fatty acids 2Genetic modification of linseed produces healthier omega 3 and 6 fatty acids 3Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases 2New anti-inflammatory strategy for cancer therapy identified by UCSD researchers 2New anti-inflammatory strategy for cancer therapy identified by UCSD researchers 3New anti-inflammatory strategy for cancer therapy identified by UCSD researchers 4