HOME >> BIOLOGY >> NEWS
Decoding gene expression in cancer tumors using noninvasive imaging

By correlating images of cancerous liver tissue with gene expression patterns, a research team led by a radiologist at the University of California, San Diego (UCSD) School of Medicine has developed tools that may some day allow physicians to view a CT image of a cancer tumor and discern its genetic activity. The study, designed to help doctors obtain the molecular details of a specific tumor or disease without having to do an invasive biopsy procedure, will be published online on May 21 in Nature Biotechnology.

According to principle investigator Michael Kuo, M.D., assistant professor of interventional radiology at UCSD, the study represents the convergence of two developing fields of medical research: the mapping of the human genome and advances in diagnostic imaging.

The research team, which included investigators from Stanford University School of Medicine, systematically compared features from CT images of liver tumors with gene expression patterns obtained from surgery and tissue biopsies. Once they pinpointed the genomic correlates of the features detected by CT imaging, the researchers found that the two very different aspects of studying cancer how the tumor looks in a CT scan and how it behaves on a molecular level had a very strong connection.

"We studied what the various genes were doing and the biological activity they were involved in such as angiogenesis or cell growth. We also looked at how the genes contributed to a particular phenotype in the liver tumor seen on the CT scans, for example, the presence of characteristics vessels, or the tumor's texture and other important diagnostic imaging traits," said Kuo.

The research process sought to reveal the relationship between genetic activity patterns in liver tumors and the tumor's appearance on CT scans, and provide a simple means of translation. The scientists initially began with approximately 135 basic tumor descriptors, and then narrowed down th
'"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
21-May-2007


Page: 1 2 3

Related biology news :

1. Decoding mushrooms secrets could combat carbon, find better biofuels and safer soils
2. Decoding protein structures helps illuminate cause of diabetes
3. Decoding the logic of olfaction
4. A low expression of MX2 gene exists in the white blood cells of narcoleptics
5. Gene expression pattern could lead to improved treatment of pediatric septic shock
6. Boston Univeristy bioengineers devise dimmer swith to regulate gene expression in mammal cells
7. Clocking in and out of gene expression
8. High cholesterol diets modify gene expression in atherosclerosis
9. Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
10. Growing nerve cells in 3-D dramatically affects gene expression
11. XDx to present recent success with AlloMap molecular expression testing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... Elgia ... inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan has joined the ... Dr. Canan previously served as Executive Director of Global Health at Bristol Myers ...
(Date:8/21/2020)... ... 18, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology ... and Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) application ... COVID-19. Approval of this IND allows Sentien to initiate a Phase 1/2 study ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... monitoring systems that are ideal for public health agencies of all sizes. With ... diseases and helping at-risk individuals find appropriate health care, Mosio helps public health ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... , ... ERT, the global leader in clinical ... one of the 100 most inspiring individuals in the life-sciences industry by PharmaVoice. ... on how they have inspired their colleagues and affected positive changes in their ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... can combine up to three different materials for use with CRM, neurostimulation, vascular, ... to three materials to meet specific design requirements, performance, and cost criteria; especially ...
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and ...
Breaking Biology Technology:
Cached News: