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Deconstructing the genome of a notorious yeast

Yeast infections are often just a minor inconvenience, but in 30% of severe cases, they can lead to death. Candida albicans, the species that causes superficial cases of thrush and vaginitis, is responsible for many of these deaths. Most susceptible are premature infants, people with HIV, cancer patients, and organ transplant patients.

Andre Nantel and an international consortium of C. albicans experts have now essentially written the dictionary for the genome of this infamous yeast. Previous studies determined its DNA sequence and used simple automated methods to look for genes. But in this new study, forty-three scientists have collaborated to present a more meaningful and detailed annotation of the 6,354 genes in the genome. This comprehensive annotation will be a vital tool for the C. albicans research community and will help in developing improved diagnoses and therapies to treat C. albicans infections.


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Contact: Paul Ocampo
pocampo@plos.org
415-624-1224
Public Library of Science
16-Jun-2005


Page: 1

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