HOME >> BIOLOGY >> NEWS
Defective movement of cell's power plants implicated in commom inherited neurological disorder

WASHINGTON, DC, January 16, 2007 Contrary to previous thinking, the inefficient movement of cell's "power plants" - the mitochondria - within a cell, rather than their low energy production, may be a contributing factor in the development of Charcot-Marie-Tooth disease (CMT), new research shows.

The study, published in the January 10 issue of The Journal of Neuroscience, is the first to show that mutations in the gene Mitofusin 2 (MFN2), known to cause a form of CMT, also disrupt the movement of the cell's mitochondria, which deliver energy within the cell. A minor disruption in mitochondria movement reduces the energy supply, weakening or even killing the cell.

In CMT, which affects 1 in 2,500 individuals, nerves and muscles in the feet and hands weaken, causing numbness and, in many cases, the loss of function. CMT affects peripheral nerves, among the longest nerves in the body where energy transport is vital.

"This work is of critical importance because the design of effective therapeutic approaches requires an understanding of the underlying disease mechanism," says Brian Popko, PhD, professor in neurological diseases at the University of Chicago who is not connected to the study.

The new research also provides strong evidence that effective energy transportation is key to long cell life, according to senior author Robert H. Baloh, PhD, at the Washington University School of Medicine.

Using rat tissue, Baloh and colleagues removed neurons similar to those affected in CMT patients. They then inserted mutant MFN2 genes in the nucleus of those cells using engineered viruses. Time-lapse videos were taken with a fluorescent microscope in order to observe the speed at which the mitochondria moved. In normal cells, mitochondria are highly mobile. However, in the neurons with mutant MFN2 genes, movement is significantly reduced.

Still unknown is exactly how the mutated MFN2 protein alters mitochondri
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
16-Jan-2007


Page: 1 2

Related biology news :

1. Defective sweet taste receptor gene shapes cat cuisine
2. St. Jude study yields secrets of chromosome movement
3. Cellular message movement captured on video
4. Information processing in the central nervous system: the signalling system controlling movement
5. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
6. Electric fish shed light on ways the brain directs movement
7. How movement lubricates bone joints
8. UNC scientists solve mystery of how largest cellular motor protein powers movement
9. 1st international study group for new movement discipline
10. Electronic chip, interacting with the brain, modifies pathways for controlling movement
11. Research links ecstasy to survival of key movement-related cells in brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology:
Cached News: