HOME >> BIOLOGY >> NEWS
Defective movement of cell's power plants implicated in commom inherited neurological disorder

WASHINGTON, DC, January 16, 2007 Contrary to previous thinking, the inefficient movement of cell's "power plants" - the mitochondria - within a cell, rather than their low energy production, may be a contributing factor in the development of Charcot-Marie-Tooth disease (CMT), new research shows.

The study, published in the January 10 issue of The Journal of Neuroscience, is the first to show that mutations in the gene Mitofusin 2 (MFN2), known to cause a form of CMT, also disrupt the movement of the cell's mitochondria, which deliver energy within the cell. A minor disruption in mitochondria movement reduces the energy supply, weakening or even killing the cell.

In CMT, which affects 1 in 2,500 individuals, nerves and muscles in the feet and hands weaken, causing numbness and, in many cases, the loss of function. CMT affects peripheral nerves, among the longest nerves in the body where energy transport is vital.

"This work is of critical importance because the design of effective therapeutic approaches requires an understanding of the underlying disease mechanism," says Brian Popko, PhD, professor in neurological diseases at the University of Chicago who is not connected to the study.

The new research also provides strong evidence that effective energy transportation is key to long cell life, according to senior author Robert H. Baloh, PhD, at the Washington University School of Medicine.

Using rat tissue, Baloh and colleagues removed neurons similar to those affected in CMT patients. They then inserted mutant MFN2 genes in the nucleus of those cells using engineered viruses. Time-lapse videos were taken with a fluorescent microscope in order to observe the speed at which the mitochondria moved. In normal cells, mitochondria are highly mobile. However, in the neurons with mutant MFN2 genes, movement is significantly reduced.

Still unknown is exactly how the mutated MFN2 protein alters mitochondri
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
16-Jan-2007


Page: 1 2

Related biology news :

1. Defective sweet taste receptor gene shapes cat cuisine
2. St. Jude study yields secrets of chromosome movement
3. Cellular message movement captured on video
4. Information processing in the central nervous system: the signalling system controlling movement
5. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
6. Electric fish shed light on ways the brain directs movement
7. How movement lubricates bone joints
8. UNC scientists solve mystery of how largest cellular motor protein powers movement
9. 1st international study group for new movement discipline
10. Electronic chip, interacting with the brain, modifies pathways for controlling movement
11. Research links ecstasy to survival of key movement-related cells in brain

Post Your Comments:
(Date:7/21/2015)... , July 21, 2015  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... wallet, announces that it has filed provisional patent ... Method. This invention highlights next ... authorizes an account, but also the user using ...
(Date:7/13/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ... today announced sampling of ClearPad ® 4300, ... (TDDI) product targeting smartphones and tablets. This new ... , best-in-class touch controller IP and systems ... in the company,s Japan Design Center. TDDI enables ...
(Date:7/9/2015)... 2015 Research and ... the "Biometrics for Banking; Market & Technology ... to their offering. The adoption for ... growth and the forecast is that by 2020 ... companies involved in delivering biometric systems to the ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
(Date:8/4/2015)...  Blueprint Medicines (NASDAQ: BPMC ), a leader ... genomically defined diseases, today announced that Jeffrey Albers ... at the 2015 Wedbush PacGrow Healthcare Conference on Tuesday, ... A live webcast of the event will be available ... website at www.blueprintmedicines.com . An archived replay of ...
(Date:8/4/2015)... Aug. 4, 2015 /PRNewswire/ -- Sinovac Biotech Ltd. (Nasdaq: ... China , today announced that it ... quarter, ended June 30, 2015, after market close on ... call on Thursday, August 13, 2015, at 8:00 a.m. ... Standard Time) to review the Company,s financial results and ...
(Date:8/3/2015)... Aug. 3, 2015  MiMedx Group, Inc. (NASDAQ: ... amniotic tissue and patent-protected processes to develop and market ... Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental sectors of ... 35 th Annual Canaccord|Genuity Growth Conference in ... Chairman and CEO, William C. Taylor , President ...
(Date:8/3/2015)... 2015  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... life-threatening diseases, today announced that it will host its ... on Thursday, August 13, 2015 at 4:30 p.m. Eastern ... the release of fiscal 2016 first quarter results.  A ... two hours after the call at the Investor Relations ...
Breaking Biology Technology:Sinovac to Host Conference Call to Report Second Quarter 2015 Unaudited Financial Results 2MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2
Cached News: