HOME >> BIOLOGY >> NEWS
Defective movement of cell's power plants implicated in commom inherited neurological disorder

WASHINGTON, DC, January 16, 2007 Contrary to previous thinking, the inefficient movement of cell's "power plants" - the mitochondria - within a cell, rather than their low energy production, may be a contributing factor in the development of Charcot-Marie-Tooth disease (CMT), new research shows.

The study, published in the January 10 issue of The Journal of Neuroscience, is the first to show that mutations in the gene Mitofusin 2 (MFN2), known to cause a form of CMT, also disrupt the movement of the cell's mitochondria, which deliver energy within the cell. A minor disruption in mitochondria movement reduces the energy supply, weakening or even killing the cell.

In CMT, which affects 1 in 2,500 individuals, nerves and muscles in the feet and hands weaken, causing numbness and, in many cases, the loss of function. CMT affects peripheral nerves, among the longest nerves in the body where energy transport is vital.

"This work is of critical importance because the design of effective therapeutic approaches requires an understanding of the underlying disease mechanism," says Brian Popko, PhD, professor in neurological diseases at the University of Chicago who is not connected to the study.

The new research also provides strong evidence that effective energy transportation is key to long cell life, according to senior author Robert H. Baloh, PhD, at the Washington University School of Medicine.

Using rat tissue, Baloh and colleagues removed neurons similar to those affected in CMT patients. They then inserted mutant MFN2 genes in the nucleus of those cells using engineered viruses. Time-lapse videos were taken with a fluorescent microscope in order to observe the speed at which the mitochondria moved. In normal cells, mitochondria are highly mobile. However, in the neurons with mutant MFN2 genes, movement is significantly reduced.

Still unknown is exactly how the mutated MFN2 protein alters mitochondri
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
16-Jan-2007


Page: 1 2

Related biology news :

1. Defective sweet taste receptor gene shapes cat cuisine
2. St. Jude study yields secrets of chromosome movement
3. Cellular message movement captured on video
4. Information processing in the central nervous system: the signalling system controlling movement
5. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
6. Electric fish shed light on ways the brain directs movement
7. How movement lubricates bone joints
8. UNC scientists solve mystery of how largest cellular motor protein powers movement
9. 1st international study group for new movement discipline
10. Electronic chip, interacting with the brain, modifies pathways for controlling movement
11. Research links ecstasy to survival of key movement-related cells in brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... Md. , June 22, 2016  The American College ... Trade Show Executive Magazine as one of the ... on May 25-27 at the Bellagio in Las ... on the highest percentage of growth in each of the ... of exhibiting companies and number of attendees. The 2015 ACMG ...
(Date:6/21/2016)... 2016 NuData Security announced today that Randy ... principal product architect and that Jon Cunningham ... development. Both will report directly to Christopher ... reflect NuData,s strategic growth in its product and ... demand and customer focus values. ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading ... the Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio ... and clinical trial team. , Using the CONSULT module, patients and physicians can schedule ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of ... their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been ... Target to its list of well-respected retailers. This list includes such fine stores ...
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
Breaking Biology Technology:
Cached News: