HOME >> BIOLOGY >> NEWS
Delving deeper into the machinery of cocaine addiction

Researchers are now understanding in greater detail the molecular machinery underlying the short-term brain changes that produce the high of cocaine, as well as the longer-term changes behind addiction. Their findings offer hope for targeted drugs that can short-circuit that addiction machinery.

In the October 20, 2005, issue of Neuron, researchers led by Eric J. Nestler and Arvind Kumar of The University of Texas Southwestern Medical Center have pinpointed a key molecular mechanism by which genes are switched on in the brain that govern both short-term and long-term effects of cocaine. Such activation is called transcriptional activation because it induces the gene to begin making copies of itself into messenger RNA that trigger protein production.

In their experiments, the researchers studied a process called "chromatin remodeling"--in which the histone proteins enfolding genes are chemically altered to render the genes active. They administered to rats both short-term, acute cocaine doses and long-term, chronic cocaine and analyzed the alteration of the histones affecting specific genes involved in cocaine response in the brain.

In their studies, they used an analytical technique called "chromatin immunoprecipitation assays" to measure the effects of cocaine on histone proteins. This technique, they emphasized, makes it possible "to study such transcriptional mechanisms in the brain in vivo and understand, with increasing complexity, how chronic cocaine administration leads to the long-term regulation of its target genes."

The researchers found that giving the rats acute doses of cocaine induced histone modifications that activated a gene called cFos, which is an important regulator of many other genes. However, this gene was desensitized by chronic cocaine.

In contrast, they found, histone modifications activated two other genes, BDNF and Cdk5, only during chronic cocaine administration. Their findings, they wrote, "direct
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
19-Oct-2005


Page: 1 2

Related biology news :

1. Nanoparticles carry chemotherapy drug deeper into solid tumors
2. Dig deeper to find Martian life
3. Climate models need deeper roots, scientists say
4. Not finding life? Dig deeper.
5. Gene-transcription machinery seen poised for action, held in check until needed
6. Biologists probe the machinery of cellular protein factories
7. Dissecting the machinery of nicotines reward
8. Reactive oxygen species shown essential for development of inner ears balance machinery
9. Clearing jams in copy machinery
10. Gambling monkeys give insight into neural machinery of risk
11. Immune cells genetic jam session is controlled by cell division machinery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... 2017  The general public,s help is being enlisted in what,s thought ... in and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the ... with the gut. The project's goal is to help advance scientific knowledge ... ...
(Date:8/15/2017)... HAMPTON, Va. , Aug. 15 2017   ivWatch LLC ... effectiveness of intravenous (IV) therapy, today announced receipt of its ISO ... (QMS) developed by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for ... "This ...
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their boarding ... ... biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at the ... to allow eligible Delta SkyMiles Members who are enrolled in CLEAR to ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... August 23, 2017 , ... ... news outlet had initiated coverage on NuLife Sciences. According to Soulstring, NuLife Sciences ... transplant industry, focused on kidney transplant technology that integrates proprietary recellularization processes intended ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... ability to manipulate 3D models of pediatric patients’ neuroanatomy and accurately tailor radiation ... of the Journal of Medical Imaging. The advance is reported in an article ...
(Date:8/23/2017)... ... August 22, 2017 , ... Mettler-Toledo, one of the market leaders in product ... . This turnkey system inspects labels, prints, and packaging properties fully automatically, and, thanks ... lines and extended as needed. , The high-end version of the V2630 was ...
(Date:8/23/2017)... (PRWEB) , ... August 22, 2017 , ... ... announced that two market innovators, Munich Re , one of the world’s ... (IQT), the strategic investor that accelerates the development of technologies to support the ...
Breaking Biology Technology:
Cached News: