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Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

known as structure-based drug design."

Capitalizing on information gleaned from their structural studies, Noel's lab has already started that structure-based program. "We have designed the first generation of inhibitors and now it is a matter of chemically synthesizing them, testing them in test tubes and cells, and imaging them bound to Scp1 in 3D," says Noel. This will set the stage for the rational fine-tuning of their efficacy using an established process Noel likens to molecular dentistry, because his group is striving to shape inhibitory molecules to fit the groove in Scp1 much the same way that a dentist molds a filling to fit the cavity in a patient's tooth.


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Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100
Salk Institute
7-Dec-2006


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