HOME >> BIOLOGY >> NEWS
Developing a more effective vaccine for tuberculosis

The microorganism that causes tuberculosis, M. Tuberculosis, infects more than a one third of the world's population. Although the currently used vaccine (M. bovis BCG) provides young children with protection from tuberculosis, it is not effective at preventing the type of tuberculosis that most adolescents and adults suffer from. Therefore, there is an intensive research effort designed to develop new, more efficient vaccines that protect all individuals from tuberculosis.

In a study that appears in the August issue of the Journal of Clinical Investigation, Steven Porcelli and colleagues from the Albert Einstein College of Medicine, New York, show that in mice, immune cells known as CD8+ T cells are more efficiently activated by strains of M. Tuberculosis that lack a protein known as SecA2 than strains of M. Tuberculosis that express SecA2. Efficient CD8+ T cell activation was associated with increased death (by a process known as apoptosis) of another immune cell type, the macrophage. Importantly, vaccination of mice and guinea pigs with M. Tuberculosis lacking SecA2 provided increased protection against infection with M. Tuberculosis than did vaccination with M. bovis BCG. These data led the authors to suggest that this approach, in combination with others currently under development, could be used to generate a new vaccine that protects all individuals from tuberculosis.

The importance of this study for the development of new vaccines to control the tuberculosis pandemic is discussed in more detail in the accompanying commentary by W. Henry Boom from Case Western Reserve University.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
1-Aug-2007


Page: 1

Related biology news :

1. Using Nanotechnology to Improve Health Care in Developing Countries
2. AAAS/EurekAlert! refocus on China with 2007 Fellowships for Science Reporters in Developing Regions
3. Developing uses for sugar-cane bagasse: Biotechnology applied to the paper industry
4. Developing radiotracers for imaging studies in addiction
5. Developing countries take the lead in a global program to catalogue human mutations
6. Developing nations may save the tropical forest
7. AAAS and EurekAlert! announce winners of the 2006 Fellowships for Reporters from Developing Regions
8. Developing nervous system sculpted by opposing chemical messengers
9. Smokeless tobacco more effective than cigarettes for delivering dangerous carcinogens into the body
10. Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
11. Implanon, Norplant and Jadelle are all effective contraceptives -- but side effects vary

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A ... pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer ... age to IVF success. , After comparing the results from the fresh and ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
(Date:10/7/2017)... , ... October 06, 2017 ... ... experience providing advanced instruments and applications consulting for microscopy and surface analysis, ... in application consulting, Nanoscience Analytical offers a broad range of contract analysis ...
Breaking Biology Technology:
Cached News: