HOME >> BIOLOGY >> NEWS
Developing nervous system sculpted by opposing chemical messengers

in medical conditions such as spinal cord injury.

Lee, along with Salk colleagues Weichun Lin, Bertha Dominguez, Jiefei Yang, Prafulla Aryal, Eugene Brandon and Fred Gage, discovered that the creation of synapses is controlled by the nerves themselves. As they grow towards the muscle cells, the nerve cells release a powerful chemical messenger from their growing ends. Called acetylcholine, this neurotransmitter 'edits out' the potential synapse sites on the muscle cell not destined to connect to a nerve. In mature animals, acetylcholine is a key neurotransmitter responsible for transmitting signals between nerve cells and muscle.

Using a combination of genetic and pharmacological techniques to block the various components of the chemical pathways involved, the Salk researchers painstakingly showed that acetylcholine works in tandem with another chemical produced by nerve cells, called agrin. Where the end of the nerve touches the muscle cell, agrin is concentrated enough to overcome the 'editing' effect of the acetylcholine. Further away from the nerve end, the levels of agrin are not high enough to overcome the more powerful influence of acetylcholine, and the redundant synapse sites are dismantled.

"The result is an interesting mechanism whereby two opposing forces work together to create the crucial synaptic connections between motor neurons and muscle cells," said co-author Prafulla Aryal.

"Although we have suspected for 25 years that something like this was happening, until now no-one has been able to demonstrate it in a living system," said Lee. "It is likely that this process occurs all over the nervous system. If you're going to repair or regenerate nerves in, for example, spinal cord injury you need to know how to form synapses for the right connections to be made."


'"/>

Contact: Cathy Yarbrough
yarbrough@salk.edu
858-452-8051
Salk Institute
2-Jun-2005


Page: 1 2

Related biology news :

1. Developing a more effective vaccine for tuberculosis
2. Using Nanotechnology to Improve Health Care in Developing Countries
3. AAAS/EurekAlert! refocus on China with 2007 Fellowships for Science Reporters in Developing Regions
4. Developing uses for sugar-cane bagasse: Biotechnology applied to the paper industry
5. Developing radiotracers for imaging studies in addiction
6. Developing countries take the lead in a global program to catalogue human mutations
7. Developing nations may save the tropical forest
8. AAAS and EurekAlert! announce winners of the 2006 Fellowships for Reporters from Developing Regions
9. Weizmann scientists discover a new line of communication between nervous system cells
10. Origins of nervous system found in genes of sea sponge, report scientists at UC Santa Barbara
11. Origins of nervous system found in genes of sea sponge

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... ... 2020 , ... Cure Glioblastoma, a registered 501(c)(3) nonprofit research ... adult brain cancer—announced today the appointments of its first Senior Fellows: John Boockvar, ... organization’s initiatives and overall vision. , "Senior Fellows are more than advisors; they ...
(Date:6/28/2020)... ... , ... In an upcoming episode scheduled for the fall of 2020, Advancements ... (POCT). Check local listings for more info. , Today, the majority of testing is ... labs throughout the country. Results are then available several days later. Now, in an ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... monoclonal antibody development services, today announced that the company has received ISO9001:2015 ... the pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... ... (EMMA International), a global leader in FDA compliance consulting has been named on ... private companies. The list represents a unique look at the most successful companies ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... Corrigan, President and CEO has been named one of the 100 most inspiring ... sectors, PharmaVoice 100 honorees are selected based on how they have inspired their ...
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, ... controller that can drive one or two switches in a push-pull configuration; yielding ...
Breaking Biology Technology:
Cached News: