HOME >> BIOLOGY >> NEWS
Differences in gene usage dramatically change bacteria's 'lifestyles'

nella and E. coli share the gene for an antibiotic resistance regulatory protein called PmrA. By controlling when other proteins are produced, PmrA can make the cell wall more resistant to damage from the antibiotic polymyxin B. The PmrA protein normally activates in response to high iron levels.

In a paper recently published in Genes and Development, Groisman's lab established that another protein, PmrD, also can activate PmrA in response to low magnesium levels.

In the new study, Groisman's lab discovered that E. coli has a different version of PmrD that is unable to turn on the PmrA protein in response to low magnesium.

"We're not really sure what the significance of low magnesium is, but there are some indications that it may be important to the bacteria's ability to survive in white blood cells or outside of the host in soil or water," Groisman says.

When scientists transplanted the Salmonella form of PmrD into E. coli, the bacteria gained the ability to resist polymyxin B in low magnesium environments.

Based on data still to be published, Groisman suspects that many other aspects of microbial lifestyle are affected by differences in regulation of identical genes.

He notes that the idea of different organisms making altered use of the same genes sprang from recent analyses of the human genome.

"Humans not only appear to have far fewer genes than expected, there also seem to be fewer genes that are unique to human DNA than anticipated," Groisman explains.

In addition to instructions for building proteins, DNA contains stretches of code that affect when genes are turned on and off. As life becomes more complex over the course of evolution, Groisman explains, these regulatory sections appear to take up larger portions of the DNA, allowing genes to be turned on and off in ways that are more intricately responsive to the environment and other factors.

Human DNA, Groisman speculates, may be hea
'"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
29-Nov-2004


Page: 1 2 3

Related biology news :

1. Photos reveal first tool usage in wild gorillas
2. Jefferson scientists patent dramatically improves
3. Growing nerve cells in 3-D dramatically affects gene expression
4. Plant size morphs dramatically as scientists tinker with outer layer
5. Lack of a key enzyme dramatically increases resistance to sepsis
6. Simple idea to dramatically improve dengue vaccinations
7. Moderate lifetime reductions in LDL cholesterol dramatically reduce risk of heart disease
8. Ownership of Southern forestland dramatically changing
9. UF Researcher: Global warming dramatically changed ancient forests
10. Caloric restriction wont dramatically extend life span in humans: UCLA research
11. New miniaturised chip dramatically reduces time taken for DNA analysis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/23/2017)... DUBLIN , Mar. 23, 2017 Research ... Anti-Theft System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 8.8% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel visited ... to the DERMALOG stand together with the Japanese Prime Minster Shinzo Abe. ... the largest German biometrics company the two government leaders could see the ... well as DERMALOGĀ“s multi-biometrics system.   Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... ... May 22, 2017 , ... Cancer diagnostics and pathology ... B2 at the Association for Pathology Informatics Annual Summit at the ... demonstrating its Cancer Diagnostic Cockpit and Consultation Portal, Inspirata will present research it ...
(Date:5/21/2017)... , ... May 20, 2017 , ... ... helps avoid the lengthy trial and error process by finding the right antidepressant ... can also strengthen the doctor-patient relationship through a personalized approach to treatment. ...
(Date:5/19/2017)... ... 2017 , ... The University City Science Center is seeking ... commercialization, and who are affiliated with the 21 partner academic and research institutions ... in its tenth round, is the first multi-institutional proof-of-concept program for the life ...
(Date:5/18/2017)... ... May 18, 2017 , ... Lajollacooks4u has ... Challenge is a two-hour team-building package designed for groups of 10-30 people. ... Abel, which include items, such as Blackened Shrimp with Edamame Salad, Pizza Rolls ...
Breaking Biology Technology:
Cached News: