HOME >> BIOLOGY >> NEWS
Differences in gene usage dramatically change bacteria's 'lifestyles'

nella and E. coli share the gene for an antibiotic resistance regulatory protein called PmrA. By controlling when other proteins are produced, PmrA can make the cell wall more resistant to damage from the antibiotic polymyxin B. The PmrA protein normally activates in response to high iron levels.

In a paper recently published in Genes and Development, Groisman's lab established that another protein, PmrD, also can activate PmrA in response to low magnesium levels.

In the new study, Groisman's lab discovered that E. coli has a different version of PmrD that is unable to turn on the PmrA protein in response to low magnesium.

"We're not really sure what the significance of low magnesium is, but there are some indications that it may be important to the bacteria's ability to survive in white blood cells or outside of the host in soil or water," Groisman says.

When scientists transplanted the Salmonella form of PmrD into E. coli, the bacteria gained the ability to resist polymyxin B in low magnesium environments.

Based on data still to be published, Groisman suspects that many other aspects of microbial lifestyle are affected by differences in regulation of identical genes.

He notes that the idea of different organisms making altered use of the same genes sprang from recent analyses of the human genome.

"Humans not only appear to have far fewer genes than expected, there also seem to be fewer genes that are unique to human DNA than anticipated," Groisman explains.

In addition to instructions for building proteins, DNA contains stretches of code that affect when genes are turned on and off. As life becomes more complex over the course of evolution, Groisman explains, these regulatory sections appear to take up larger portions of the DNA, allowing genes to be turned on and off in ways that are more intricately responsive to the environment and other factors.

Human DNA, Groisman speculates, may be hea
'"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
29-Nov-2004


Page: 1 2 3

Related biology news :

1. Photos reveal first tool usage in wild gorillas
2. Jefferson scientists patent dramatically improves
3. Growing nerve cells in 3-D dramatically affects gene expression
4. Plant size morphs dramatically as scientists tinker with outer layer
5. Lack of a key enzyme dramatically increases resistance to sepsis
6. Simple idea to dramatically improve dengue vaccinations
7. Moderate lifetime reductions in LDL cholesterol dramatically reduce risk of heart disease
8. Ownership of Southern forestland dramatically changing
9. UF Researcher: Global warming dramatically changed ancient forests
10. Caloric restriction wont dramatically extend life span in humans: UCLA research
11. New miniaturised chip dramatically reduces time taken for DNA analysis

Post Your Comments:
(Date:11/21/2014)... REDMOND, Wash. , Nov. 20, 2014 ... access for the Internet of Things (IoT), today announced ... position of chief operating officer. Previously a strategic advisor ... marketing, finance, and operations. Mr. Traynor is based out ... . He reports to Chris Muench , ...
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
(Date:11/15/2014)... 2014  While we may still be a few years ... "Star Trek" to gain instant access to all that ailed ... smartphones and tablets for monitoring and measuring our health are ... may seem a tad Orwellian to some, but a new ... these technological opportunities into their healthcare regime. These ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
(Date:12/17/2014)... Dec. 17, 2014   Synageva BioPharma Corp. ... therapeutic products for rare disorders, announced today its presentation ... in San Francisco, CA. ... Executive Officer, will present on Monday, January 12, 2015, ... will be webcast live and may be accessed from ...
(Date:12/15/2014)... Limited (NASDAQ GS: SEED) (" Origin ", or the " ... China , today announced that the Company will ... 2014, before the market opens on Thursday, January 8, 2015. ... 8, 2015, at 8:00 a.m. ET / 9:00 p.m. ... participate in the call, please dial +1-888-346-8982 in ...
(Date:12/13/2014)... December 12, 2014 The DNA ... in 2013, and is expected to grow at ... , Browse through the TOC of the DNA ... trends and segments, with help of various tables ... global DNA Microarray market consists of instrument, consumables, ...
(Date:12/13/2014)... Texas , Dec. 12, 2014  Vermillion, Inc. ... announced today the appointments of Veronica G. H. ... to the Company,s Board of Directors, bringing the total ... independent. Jim LaFrance , Chairman, ... am tremendously pleased to announce the appointments of Veronica ...
Breaking Biology Technology:Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 4Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 2Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 3
Cached News: