HOME >> BIOLOGY >> NEWS
Differences in gene usage dramatically change bacteria's 'lifestyles'

nella and E. coli share the gene for an antibiotic resistance regulatory protein called PmrA. By controlling when other proteins are produced, PmrA can make the cell wall more resistant to damage from the antibiotic polymyxin B. The PmrA protein normally activates in response to high iron levels.

In a paper recently published in Genes and Development, Groisman's lab established that another protein, PmrD, also can activate PmrA in response to low magnesium levels.

In the new study, Groisman's lab discovered that E. coli has a different version of PmrD that is unable to turn on the PmrA protein in response to low magnesium.

"We're not really sure what the significance of low magnesium is, but there are some indications that it may be important to the bacteria's ability to survive in white blood cells or outside of the host in soil or water," Groisman says.

When scientists transplanted the Salmonella form of PmrD into E. coli, the bacteria gained the ability to resist polymyxin B in low magnesium environments.

Based on data still to be published, Groisman suspects that many other aspects of microbial lifestyle are affected by differences in regulation of identical genes.

He notes that the idea of different organisms making altered use of the same genes sprang from recent analyses of the human genome.

"Humans not only appear to have far fewer genes than expected, there also seem to be fewer genes that are unique to human DNA than anticipated," Groisman explains.

In addition to instructions for building proteins, DNA contains stretches of code that affect when genes are turned on and off. As life becomes more complex over the course of evolution, Groisman explains, these regulatory sections appear to take up larger portions of the DNA, allowing genes to be turned on and off in ways that are more intricately responsive to the environment and other factors.

Human DNA, Groisman speculates, may be hea
'"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
29-Nov-2004


Page: 1 2 3

Related biology news :

1. Photos reveal first tool usage in wild gorillas
2. Jefferson scientists patent dramatically improves
3. Growing nerve cells in 3-D dramatically affects gene expression
4. Plant size morphs dramatically as scientists tinker with outer layer
5. Lack of a key enzyme dramatically increases resistance to sepsis
6. Simple idea to dramatically improve dengue vaccinations
7. Moderate lifetime reductions in LDL cholesterol dramatically reduce risk of heart disease
8. Ownership of Southern forestland dramatically changing
9. UF Researcher: Global warming dramatically changed ancient forests
10. Caloric restriction wont dramatically extend life span in humans: UCLA research
11. New miniaturised chip dramatically reduces time taken for DNA analysis

Post Your Comments:
(Date:10/22/2014)... 2014  Leading identity analyst firm Acuity Market Intelligence ... world,s population will have a chip-based National eID card, ... . Asia , with its vast ... more than 60% of all National eID cards issued ... "The Global National eID Industry Report: 2014 ...
(Date:10/19/2014)... in India over the last 30 years contributed ... growth during that time, according to a new ... Change ., "Energy access is fundamental to development: ... including education, communication, and health," says IIASA researcher ... increased energy access is widely agreed to be ...
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Improved electricity access has little impact on climate change 2Whole-exome sequencing shows potential as diagnostic tool 2
(Date:10/22/2014)... NJ (PRWEB) October 22, 2014 ... and services – has been working with a team ... and New Haven Farms Community Farming Collaborative to provide ... ePRO solution. The study, which started in May, ... program that provides participants weekly exposure to and participation ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Grace Century, ... and healthcare projects, announces the addition of Dr. ... to its advisory team. Dr. Siddiqui will provide further ... , A graduate of University College Medical School ... degreed in medicine in 2001. With further certification as ...
(Date:10/22/2014)... 22, 2014 According to new ... Service Type (Consulting, Integration, Deployment & Support), by ... Model (Public, Private, Others (Hybrid & Community)) - ... and segments the Cloud Professional Services Market into ... of revenues. It also identifies the drivers and ...
(Date:10/22/2014)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... its Oral Amphotericin B program.  The company recently ... work involving samples from HIV/AIDS patients exposed ... pre clinical studies and regulatory filings to move ... utilizing approximately $700,000 of funding and technological advice ...
Breaking Biology Technology:myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3
Cached News: