HOME >> BIOLOGY >> NEWS
Discoveries by UAB and Florida scientists may help transplanted organs survive longer

BIRMINGHAM, Ala. Scientists may have found a way to dramatically slow organ transplant rejection by as much as several years.

That's the promising implication of an animal study carried out by researchers at the University of Alabama at Birmingham (UAB) and the University of Florida (UF) published in today's (May 2) issue of Proceedings of the National Academy of Sciences.

The research team reported that they have identified the biological pathway of a potent molecule that could delay rejection of transplanted organs by preventing blood-vessel deterioration.

"One of the principal problems for kidney transplantation is organ availability," said Mark A. Atkinson, Ph.D., a study co-author and director of the Center for Immunology and Transplantation Research at UF. "That occurs in part because after several years, people with kidney transplants often lose function of the organ. With about 60,000 people on the waiting list for a transplant, it would help immensely to find a way to reduce a patient's need for a second or third kidney."

The helpful molecule, IL-10, has anti-inflammatory, immunosuppressive and other properties that help keep blood vessels healthy. Chronic vascular rejection, characterized by thickening of the interior lining that eventually chokes off the blood supply, is a major cause of the loss of function in solid organ transplants.

The study, carried out in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects.

Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of the report, said the group found that IL-10 was active through the heme oxygenase-dependent (HO-1) biological pathway between cells.

"We found that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal
'"/>


2-May-2005


Page: 1 2

Related biology news :

1. Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
2. Discoveries should aid research into cause of ALS
3. Discoveries may advance stem cell therapy for Parkinsons, cancer patients
4. Census of Marine Life - Discoveries and Highlights 2004: Scientists add 4m+ records, 13,000 species
5. Study finds contaminated water reaching Floridas offshore keys
6. Florida Tech explores microalgae for biofuel
7. NASA satellite data helps assess the health of Floridas coral reef
8. University of Florida study shows leptin could combat type 2 diabetes
9. Cigarette smoke blocks cell repair mechanism, University of Florida study shows
10. Discovery of genetic mutation in Florida beach mice suggests extinct mammoth had light and dark fur
11. Florida Tech to host 25th Anniversary Indian River Lagoon Symposium

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... ... November 14, 2018 , ... ... a tool that speeds up the analysis and publication of biomedical data from ... of their studies. Until now, the primary method available to share biomedical research ...
(Date:11/15/2018)... ... November 14, 2018 , ... ... will present new scientific evidence on gene-disease relationships and how it supports medical ... be held in Atlanta, November 14-17. , Ambry has been selected by ...
(Date:11/13/2018)... EAST NORRITON, Pa. (PRWEB) , ... November 13, ... ... and Chief Executive Officer Jonathan Retano will be a featured presenter at the ... the company will host a hospitality suite on Friday, November 16, where conference ...
Breaking Biology News(10 mins):
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth in Sandy Springs, ... from Dr. Dan Myers at THE DENTIST Centers without a referral. Dr. Myers is ... the last 20 years. He now offers skilled dental care in two practice locations ...
(Date:11/13/2018)... ... November 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, ... of Kauai. Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is ... he began traveling to the island of Kauai on an almost weekly basis to ...
(Date:11/13/2018)... ... , ... , Park Systems, world leader in Atomic Force Microscopes (AFM) announces ... AFM technology in China, Park Systems has decided to provide direct support for China’s ... with Park AFM. , The Grand Opening of the Park Beijing Office will be ...
(Date:11/9/2018)... ... November 08, 2018 , ... ... States, adopted a machine-learning powered approach to increasing recovery rates by creating a ... Artificially Intelligent Collections (AIC) product developed by NLP Logix, a Jacksonville, Florida-based AI ...
Breaking Biology Technology:
Cached News: