HOME >> BIOLOGY >> NEWS
Discoveries by UAB and Florida scientists may help transplanted organs survive longer

BIRMINGHAM, Ala. Scientists may have found a way to dramatically slow organ transplant rejection by as much as several years.

That's the promising implication of an animal study carried out by researchers at the University of Alabama at Birmingham (UAB) and the University of Florida (UF) published in today's (May 2) issue of Proceedings of the National Academy of Sciences.

The research team reported that they have identified the biological pathway of a potent molecule that could delay rejection of transplanted organs by preventing blood-vessel deterioration.

"One of the principal problems for kidney transplantation is organ availability," said Mark A. Atkinson, Ph.D., a study co-author and director of the Center for Immunology and Transplantation Research at UF. "That occurs in part because after several years, people with kidney transplants often lose function of the organ. With about 60,000 people on the waiting list for a transplant, it would help immensely to find a way to reduce a patient's need for a second or third kidney."

The helpful molecule, IL-10, has anti-inflammatory, immunosuppressive and other properties that help keep blood vessels healthy. Chronic vascular rejection, characterized by thickening of the interior lining that eventually chokes off the blood supply, is a major cause of the loss of function in solid organ transplants.

The study, carried out in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects.

Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of the report, said the group found that IL-10 was active through the heme oxygenase-dependent (HO-1) biological pathway between cells.

"We found that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal
'"/>


2-May-2005


Page: 1 2

Related biology news :

1. Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
2. Discoveries should aid research into cause of ALS
3. Discoveries may advance stem cell therapy for Parkinsons, cancer patients
4. Census of Marine Life - Discoveries and Highlights 2004: Scientists add 4m+ records, 13,000 species
5. Study finds contaminated water reaching Floridas offshore keys
6. Florida Tech explores microalgae for biofuel
7. NASA satellite data helps assess the health of Floridas coral reef
8. University of Florida study shows leptin could combat type 2 diabetes
9. Cigarette smoke blocks cell repair mechanism, University of Florida study shows
10. Discovery of genetic mutation in Florida beach mice suggests extinct mammoth had light and dark fur
11. Florida Tech to host 25th Anniversary Indian River Lagoon Symposium

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... , ... Accumen Inc. is helping healthcare get better, faster. ... to provide COVID-19 saliva testing kits nationally. , “Accumen has been partnering ... years. Early in the COVID-19 crisis, we identified supply chain gaps and began ...
(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life ... and compliance, announces a new solution to manage regulated workloads on Microsoft Azure. ... their technology stack complies with FDA and global regulations. USDM's new managed service ...
(Date:7/10/2020)... CHURCH, Va. (PRWEB) , ... July 08, 2020 ... ... The Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July ... may need a comparability study, but what is the most effective way to ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... The ... radiation centers in 16 countries, has reached its 20th anniversary of worldwide use. ... routine use at top universities including University of Pennsylvania, University of Michigan, University ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). ... Specifically, for medical devices, the NMPA has departments dealing with medical device registration (pre-market ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt ... the market and we were pleased that the IFT jury recognized that.” reFRESH™ couples ... a natural way to extend the shelf life and improve the safety of perishable ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a ... and food industries, is pleased to announce that Charles Galea has joined its ... , Charles is an accomplished and results-driven sales executive with over 10 years ...
Breaking Biology Technology:
Cached News: