Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment

>The two genes appear to influence stem cell self-renewal by controlling two different arms of the pathway, says Korkaya. In breast cancer, the loss of PTEN is linked to nearly a quarter of all cases, while the overproduction of HER2 is associated with nearly 40 percent of all cases. Patients with a combined defect of PTEN loss and HER2 amplification represent worse prognosis than either defect alone.

To replicate this clinical phenomenon and study the link between stem cell self-renewal and tumorigenesis, the researchers altered the expression of the two genes in a line of human breast carcinoma cells. In experimental settings, their results confirmed this clinical data that either defect increases stem cell population by three to five times. Furthermore, Korkaya observed an additive effect and an approximate 10-fold increase in stem cell population when they created a cell line with deleted PTEN and HER2 overexpression. Another property of aggressive tumors is metastasis; the team also found that these cells had increased invasive capacity in a matrigel invasion assay.

"In general, tumors are heterogeneous including stem and non-stem cell populations in a given malignancy," Korkaya said. "If the stem cells acquired mutations in their self-renewing pathways, they will then begin reproducing at an accelerated rate, leading to a particularly aggressive form of cancer."

The researchers believe further studies will identify new biomarkers that will enable physicians to clinically screen patients for mammary stem cells and provide specific treatments designed to target these cells.

Local Radiotherapy Might Contribute to Leukemia Risk in Breast Cancer by Recruitment of Hematopoietic Stem Cells: Abstract 5050

Radiation therapy affects not only the cancer mass, but also the surrounding tissues, including the bone marrow. Signals from the cells in the bone marrow damaged by cancer radiotherapy could be involved

Contact: Staci Vernick Goldberg
American Association for Cancer Research

Page: 1 2 3 4 5 6

Related biology news :

1. Discoveries should aid research into cause of ALS
2. Discoveries may advance stem cell therapy for Parkinsons, cancer patients
3. Discoveries by UAB and Florida scientists may help transplanted organs survive longer
4. Census of Marine Life - Discoveries and Highlights 2004: Scientists add 4m+ records, 13,000 species
5. Newly created cancer stem cells could aid breast cancer research
6. ESF EURYI award winner aims to stop cancer cells reading their own DNA
7. OHSU turns mouse into factory for human liver cells
8. UCLA scientists produce functioning neurons from human embryonic stem cells
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
11. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells

Post Your Comments:

(Date:6/4/2019)... ... June 04, 2019 , ... Molecular Devices, ... Susan Murphy as the new President of Molecular Devices, replacing Greg Milosevich who ... company, Danaher Corporation. , Since joining Molecular Devices in a scientific engineering role, ...
(Date:6/3/2019)... ... June 03, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , June ...
(Date:5/31/2019)... ... 2019 , ... Join Julie Peacock, Vice President of Product ... June 19, 2019 at 1pm EDT where she will demonstrate how role-based data ... contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. , ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 13, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... redesigned website aims to improve LDA’s ability to communicate directly with the marketplace; ...
(Date:5/4/2019)... ... 03, 2019 , ... Diopsys Inc, the world leader in ... vision test, a new full field electroretinography (ffERG) protocol designed to detect ... Americans will have glaucoma, with black Americans having the highest prevalence rate. This ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... in the greater Boston area. Gone are the days of painful hair transplant ... Robotic Hair Restoration System is the only robotic intelligent solution to offer a ...
(Date:4/16/2019)... , ... April 16, 2019 , ... ... systems, applications, and technology, today announced that Bank South Pacific (BSP), the largest ... RFP process. The bank awarded Fulcrum a contract to deliver a fingerprint-based Know ...
Breaking Biology Technology:
Cached News: