Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment

in the development of secondary acute myeloma by drawing hematopoietic stem cells, the blood-producing cells of the bone marrow, from distant sites into the irradiated bone marrow, according to researchers from the Ontario Cancer Institute. Their findings suggest that local radiotherapy leads to leukemia, even though radiotherapy directly affects only a small fraction of the bone marrow.

While often effective in treating breast cancer, localized radiation therapy increases the risk of developing secondary cancer, which most frequently manifests in the form of acute myeloid leukemia. In breast cancer, less than 10 percent of bone marrow is exposed to radiation therapy, yet a much higher percentage of hematopoietic stem cells could be affected.

To understand this effect, the researchers labeled and tracked the movement of hematopoietic stem cells in an animal model. Following local radiation therapy, they found that more than four times more hematopoietic stem cells accumulated in the irradiated bone marrow, compared to the non-irradiated bone marrow. Through molecular screening, they found that cells in the area were creating an overabundance of three protein signals known to recruit hematopoietic stem cells: SDF1, MMP2 and MMP9.

"Cells within the bone marrow send out these chemical signals as a sort of call for help, which recruits a large number of hematopoietic stem cells into the affected areas, supposedly to replace damaged cells," said Carlo Bastianutto, Ph.D., a scientific associate at the Ontario Cancer Institute. "In effect, this becomes a trap for this specific population of stem cells, drawing them into the bone marrow present in the radiation field and getting them exposed to the following radiation cycles. This story might repeat at every cycle of radiation therapy, therefore increasing the chance of producing a leukemic stem cell."

According to the OCI researchers, the recruiting signal might be stopped by chemi

Contact: Staci Vernick Goldberg
American Association for Cancer Research

Page: 1 2 3 4 5 6

Related biology news :

1. Discoveries should aid research into cause of ALS
2. Discoveries may advance stem cell therapy for Parkinsons, cancer patients
3. Discoveries by UAB and Florida scientists may help transplanted organs survive longer
4. Census of Marine Life - Discoveries and Highlights 2004: Scientists add 4m+ records, 13,000 species
5. Newly created cancer stem cells could aid breast cancer research
6. ESF EURYI award winner aims to stop cancer cells reading their own DNA
7. OHSU turns mouse into factory for human liver cells
8. UCLA scientists produce functioning neurons from human embryonic stem cells
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
11. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells

Post Your Comments:

(Date:10/8/2019)... ... October 08, 2019 , ... ... collaboration with the National Research Council of Canada (NRC) to create the ... and lab-on-a-chip technologies and in manufacturing, LIFT will offer a competitive capacity ...
(Date:10/8/2019)... ... October 07, 2019 , ... Imaging data sets are ... as optical projection tomography, optical coherence tomography, echocardiogram, light sheet microscopy, MRI and ... sets inhouse, a lot of research groups struggle with transforming these large and ...
(Date:10/4/2019)... ... October 04, 2019 , ... Representatives with ... 10 at the Grand Elysée Hamburg Rothenbaumchaussee in Hamburg. , “To better connect ... said Miao Guo, Vice President of Operations and spokesperson for MyBioGate. , Guo ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... , ... October 02, 2019 , ... ... life sciences leadership firm that is enabling clinical program outsourcing success by cultivating ... by award-winning pharma and biotech veteran executive Brenda Reese, phaseUP™ brings clients deep, ...
(Date:10/3/2019)... ... October 02, 2019 , ... ... spectrometry, is pleased to announce that it has moved into a new, 5000 ... analytical instruments, the new facility demonstrates the company's continuous commitment to quality research ...
(Date:9/24/2019)... , ... September 24, 2019 ... ... presenting their latest research in the area of high-level X-ray methods using ... Pamela Smith, COO of Improved Pharma, will present “Synchrotron X-Ray Diffraction and ...
(Date:9/24/2019)... POWAY, Calif. (PRWEB) , ... September 24, 2019 ... ... human adipose-derived stem cell company, has completed training and site qualification for clinical ... the process of recruitment and screening of potential clinical trial participants. , Clinical ...
Breaking Biology Technology:
Cached News: