HOME >> BIOLOGY >> NEWS
Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment

eagues discovered that as few as 10 cells producing high amounts of CD44 were capable of creating tumors in an animal model. In contrast, other tumor cells were 10 to 50 times less tumorigenic. The fact that they were tumorigenic at all, the researchers say, indicates that CD44 alone is unlikely to be the sole indicator of stem cell-ness among the tumor cell population. However, according to Chu, the discovery that high CD44 producing cells have cancer stem cell properties provides an entry point into further research into cancer-causing stem cells.

BRCA1 regulates human mammary stem cell self-renewal and differentiation: Abstract 5700

Mutations in the well-known breast cancer susceptibility gene BRCA1 have a role in the propagation of aggressive stem cell-driven cancer. The findings, according to researchers at the University of Michigan, offer further evidence that breast cancer treatment strategies require a stronger focus on the stem cells that drive the disease.

"Our lab previously identified the presence of mammary stem cells and, since BRCA1 is such a strong predictor of breast cancer, we were interested in the involvement of the gene in stem cells," said Suling Liu, Ph.D., a researcher at the University of Michigans Comprehensive Cancer Center. "If mammary stem cells are, indeed, the driving force of breast cancer, then we need to know more about their function if we hope to create more effective therapies."

To investigate the role of the gene in stem cells, the team engineered a lentivirus to carry small interfering RNA segments that, in effect, silence the BRCA1 gene. They then observed how a population of mammary stem cells functioned without the ability to produce BRCA1. When BRCA1 was inhibited, the number of stem cells was increased by 75 percent. These new cells, in turn, produced three times the normal amount of a stem cell marker protein ALDH1.

In an animal model of the disease, the knockdow
'"/>

Contact: Staci Vernick Goldberg
goldberg@aacr.org
267-646-0616
American Association for Cancer Research
18-Apr-2007


Page: 1 2 3 4 5 6

Related biology news :

1. Discoveries should aid research into cause of ALS
2. Discoveries may advance stem cell therapy for Parkinsons, cancer patients
3. Discoveries by UAB and Florida scientists may help transplanted organs survive longer
4. Census of Marine Life - Discoveries and Highlights 2004: Scientists add 4m+ records, 13,000 species
5. Newly created cancer stem cells could aid breast cancer research
6. ESF EURYI award winner aims to stop cancer cells reading their own DNA
7. OHSU turns mouse into factory for human liver cells
8. UCLA scientists produce functioning neurons from human embryonic stem cells
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
11. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... ... June 12, 2019 , ... ... discovery services, Abveris plans to leverage the Geneious Biologics platform as a premium ... Chief Technology Officer at Abveris, says: “The Geneious team has done an excellent ...
(Date:6/4/2019)... ... June 04, 2019 , ... In’Tech Medical SAS ( ... Q1-19 revenues of $31M, up 12% from Q1-18. The growth is associated with ... & operational excellence initiatives worldwide. , Laurent Pruvost , President & CEO ...
(Date:6/3/2019)... ... June 03, 2019 , ... Stay on top of current hot topics through ... Access to all webinars is free, so be sure to register today to save ... http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , June 10 ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... , ... June 18, 2019 , ... Personalized Stem ... New Drug (IND) application to the FDA for use of a person’s own adipose-derived ... a treatment of osteoarthritis in the knee. This IND is the first of ...
(Date:6/11/2019)... ... June 11, 2019 , ... ... Clinic, a national leader in opioid treatment, announced today they are partnering to ... , Mytonomy recently deployed its virtual care platform at the Mayo Clinic to ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... applications from the USPTO providing proprietary interest to our methodology, processes, and ... DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep ...
(Date:5/21/2019)... ADDIS ABABA, Ethiopia (PRWEB) , ... May 21, ... ... Lehranstalt für Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing ... the brewing and malting industry in Africa. The event, which is supported through ...
Breaking Biology Technology:
Cached News: