Discovery at the Feinstein suggests new treatment approach for inflammatory conditions

MANHASSET, NY -- Scientists at The Feinstein Institute for Medical Research have made a discovery that may change the way inflammatory conditions are treated. The researchers looked at certain nerve cell receptors in the brain and found they control inflammation in the body. The discovery presents a potential new approach for treating inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease. The study, by Valentin Pavlov, PhD, Kevin Tracey, MD, and colleagues, was published in the March 28 issue of Proceedings of the National Academy of Sciences.

The brain chemical acetylcholine binds to muscarinic receptors on nerve cells in the brain, causing the brain to send messages to the body that slow the inflammatory response. The receptors can be stimulated though a number of mechanisms, including by use of drugs that mimic the effect of acetylcholine, by blocking an enzyme that naturally destroys acetylcholine, or by provoking the nerve cells to release more acetylcholine. The researchers also tested muscarinic receptors in other parts of the body, but unlike the central receptors in the brain, they do not play an essential role in controlling the inflammatory response.

"Medications in a class of drugs called centrally acting cholinergic agents are already available on the U.S. market, approved by the Food and Drug Administration (FDA) for treating Alzheimer's disease," said Dr. Tracey, who is also Director and Chief Executive Officer of The Feinstein. "Our next step will be to conduct a clinical trial with one of these drugs as an anti-inflammatory agent to evaluate its effect on inflammatory measures in healthy people."

The research team plans to test galantamine, a drug whose active ingredient was first extracted from a plant and is now synthesized in the laboratory, which works primarily by blocking the enzyme that destroys acetylcholine. The drug allows the nerve cells in the brain to communicate their anti-inflammatory

Contact: Christina Verni
North Shore-Long Island Jewish (LIJ) Health System

Page: 1 2

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery could help bring down price of DNA sequencing
4. Discovery in orange cauliflower may lead to more nutritious crops
5. Discovery of new family of pseudo-metallic chemicals
6. Discovery in plants suggests entirely new approach to treating human cancers
7. Discovery of master switch for the communication process between chloroplast and nuclei of plants
8. Discovery of new cave millipedes casts light on Arizona cave ecology
9. Discovery of chemical profiles for infectious diarrhea
10. Discovery could lead to better control of hemorrhagic fever viruses
11. Honey bee researcher wins National Research Initiative Discovery Award

Post Your Comments:

(Date:8/19/2019)... ... August 19, 2019 , ... Since ... use of ultra-thin two dimensional slices which are placed on microscope slides, stained ... complex tissues and complicated features such as vasculature and thus researchers in the ...
(Date:8/15/2019)... ... ... Deep Science Ventures (DSV), a new paradigm for applied science, today announced ... 100 companies over the next 10 years to address the urgent need for new ... was founded to create a better method for launching science companies; one that takes ...
(Date:8/15/2019)... ... , ... Serialization deadlines in the US and European Union ... becomes fully applied in the United States in 2023, pharmaceutical companies are scrutinizing ... most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal system capabilities. ...
Breaking Biology News(10 mins):
(Date:8/15/2019)... ... August 15, 2019 , ... PathSensors announced today that Roger ... of the Institute of Food Technologists (IFT) Board of Directors, Illinois Institute of ... for Food Safety and Applied Nutrition (JIFSAN) Advisory Council and the University of ...
(Date:8/14/2019)... STATE COLLEGE, Pa. (PRWEB) , ... August 13, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, announced the appointment ... of healthcare industry experience to the Board. , Mark McLoughlin will lend his ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... prepackaged mobile phases for QC laboratories. After gaining a few significant clients, Lifecycle ... approach into a valued supplier of manufacturing processing solutions, including reagents for tissue ...
(Date:8/8/2019)... , ... August 08, 2019 , ... ... Agents for sales and service organizations, today announced that the company’s Studio ... Award for the IVA market . Inference will officially accept the award at ...
Breaking Biology Technology:
Cached News: