HOME >> BIOLOGY >> NEWS
Discovery could help bring down price of DNA sequencing

EVANSTON, IL -- In May, Nobel Laureate James D. Watson, the scientist who co-discovered the structure of DNA, became the first person to receive his own complete personal genome -- all three billion base pairs of his DNA code sequenced. The cost was $1 million, and the process took two months.

A million dollars for a map of all your genes is way out of reach for most people. The National Institutes of Health would like to bring it down to $1,000 by the year 2014, but plenty of technological hurdles remain before youll be able to secure your genetic blueprint for this more affordable price.

One promising method for speeding up DNA sequencing, and thus reducing its cost, is nanopore sequencing, where DNA moves through a tiny hole, much like thread going through a needle. The technique can detect individual DNA molecules, but the DNA gallops through so fast that it is impossible to read the individual letters, or bases, and determine the sequence. (The four letters of the genomic alphabet are A, T, G and C, each representing one of the base nucleotides that make up DNA.)

Using a theory based on classical hydrodynamics, a Northwestern University researcher now has explained the nature of the resistive force that determines the speed of the DNA as it moves through the nanopore, which is just five to 10 nanometers wide. (One nanometer is a billionth of a meter.) This understanding could help scientists figure out how to slow the DNA down enough to make it readable and usable -- for medical and biotechnology applications, in particular.

Sandip Ghosal, associate professor of mechanical engineering in Northwesterns McCormick School of Engineering and Applied Science, is the first to apply classical hydrodynamics to the interaction of DNA with a nanopore. The findings, an important step toward achieving single-base resolution in nanopore sequencing, were published in the June 8 issue of the journal Physical Review Letters (PRL).


'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
29-Jun-2007


Page: 1 2

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery in orange cauliflower may lead to more nutritious crops
4. Discovery of new family of pseudo-metallic chemicals
5. Discovery in plants suggests entirely new approach to treating human cancers
6. Discovery of master switch for the communication process between chloroplast and nuclei of plants
7. Discovery of new cave millipedes casts light on Arizona cave ecology
8. Discovery of chemical profiles for infectious diarrhea
9. Discovery could lead to better control of hemorrhagic fever viruses
10. Honey bee researcher wins National Research Initiative Discovery Award
11. Faculty of 1,000 biology launch Pharmacology & Drug Discovery Faculty

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/27/2020)... , ... January 27, 2020 , ... On Thursday, February ... Solutions Life Sciences, Reed Tech and Richard Castle, Global Account Manager Medical ... discussing the procedure, other topics include EU MDR timing deadlines, best practices in creating ...
(Date:1/24/2020)... ... January 24, 2020 , ... Shoreline Biome , ... strain level, today announced that the company will debut a novel new DNA isolation ... , The new product, Shoreline Biome's Rapid Prep kit, is a fast and easy-to-use ...
(Date:1/24/2020)... (PRWEB) , ... January 24, 2020 , ... Worldwide ... Technology President Dr. Stanley Stanbridge and Vice President of Sales and Marketing Jeff ... Fox Business Network as sponsored content on Sunday, Jan. 26, 2020 at 5:30 p.m. ...
Breaking Biology News(10 mins):
(Date:1/27/2020)... ... 27, 2020 , ... Valencell, the leading innovator in wearable ... by Halma plc , a FTSE 100 global group of life-saving technology ... WSJ Joshua Fund. A representative from Halma will join the Valencell board of ...
(Date:1/23/2020)... , ... January 22, 2020 , ... ... developments in the cosmetic surgery industry at two recent North American investor forums ... at the Canaccord Genuity Medical Technologies & Diagnostics Forum on November 21, 2019 ...
(Date:1/22/2020)... , ... January 21, 2020 , ... QCDx , ... biopsy from a simple blood draw, today announced the sale of the proprietary RareScope™ ... Rare Scope will be used in clinical cancer research. , “The RareScope can detect ...
(Date:1/8/2020)... ... January 08, 2020 , ... Anomet Products ... properties for use in harsh environments inside or outside of the human body. ... metals or alloys to achieve specific properties such as corrosion-resistance, biocompatibility, or operation ...
Breaking Biology Technology:
Cached News: