HOME >> BIOLOGY >> NEWS
Discovery could lead to better control of hemorrhagic fever viruses

Researchers report discovering the receptor through which a group of life-threatening hemorrhagic fever viruses enter and attack the body's cells, and show that infection can be inhibited by blocking this receptor. The findings, to be published online by the journal Nature on February 7, give a clue to the high lethality of New World arenaviruses, suggest a way of reducing the severity of infection, and point the way toward a sorely needed treatment strategy.

The four viruses, known as the Machupo, Guanarito, Junin and Sabia viruses, cause Bolivian, Venezuelan, Argentine and Brazilian hemorrhagic fever, respectively, with mortality rates of about 30 percent. No vaccine is available, though a weakened form of Junin virus has been given to Argentinean farmers with some success. In addition to causing occasional disease outbreaks, mostly in poor, rural areas of South America, the viruses are of U.S. government interest because of their potential as bioterrorism agents. All four are classified as NIAID Category A Priority Pathogens and must be handled in Biosafety Level 4 containment facilities.

The researchers, led by Hyeryun Choe, PhD, of Children's Hospital Boston's Pulmonary Division, and Michael Farzan, PhD, of Harvard Medical School (HMS), first investigated the Machupo virus. To identify its cellular receptor, they made copies of the "spike" protein, used by the virus to gain entry into cells, and added it to cells from African green monkeys, known to be highly susceptible to Machupo virus infection. Later, they broke the cells open and isolated the spike protein and the cellular protein to which it had attached itself. Then, using a technique called mass spectrometry, they analyzed this attached cellular protein to determine its identity.

The receptor, identified in Choe's lab by Jonathan Abraham, PhD, an MD-PhD student at HMS, turned out to be transferrin receptor 1 (TfR1), a well-known protein that is key in enabling cells t
'"/>

Contact: Rachel Pugh
rachel.pugh@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
7-Feb-2007


Page: 1 2 3

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery could help bring down price of DNA sequencing
4. Discovery in orange cauliflower may lead to more nutritious crops
5. Discovery of new family of pseudo-metallic chemicals
6. Discovery in plants suggests entirely new approach to treating human cancers
7. Discovery of master switch for the communication process between chloroplast and nuclei of plants
8. Discovery of new cave millipedes casts light on Arizona cave ecology
9. Discovery of chemical profiles for infectious diarrhea
10. Honey bee researcher wins National Research Initiative Discovery Award
11. Faculty of 1,000 biology launch Pharmacology & Drug Discovery Faculty

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... , ... May 28, 2020 , ... ... that interim results from their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) ... Meeting which will take place virtually on May 29th, 2020. Dr. Benedito Carneiro, ...
(Date:5/21/2020)... SOMERSET, N.J. (PRWEB) , ... May 20, 2020 ... ... technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and ... Catalent Cell & Gene Therapy, will be presenting at the ISCT 2020 Paris ...
(Date:5/14/2020)... ... 13, 2020 , ... DuPont Nutrition & Biosciences (DuPont) today ... dairy market. This unique product allows for process optimization and cost reduction, enabling ... across North America. , Among the numerous benefits Bonlacta™ offers, it is fast ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 12, 2020 , ... NanoString Technologies ... together thousands of industry leaders, clinicians, research scientists, medical professionals and academics from ... June, MD, Director of the Center for Cellular Immunotherapies at the Perelman School ...
(Date:5/9/2020)... , ... May 08, 2020 , ... Worldwide Business ... their successful business program on Sunday, May 10, 2020 and Wednesday, May 13, 2020 ... This episode’s exclusive interviews will spotlight key executives from Techolution and ...
(Date:5/5/2020)... ... 05, 2020 , ... Smart Meter, a diabetes ... iGlucose® LTE Cat-M Cellular Connected Diabetes Blood Glucose Monitor and Remote Patient ... and broadest cellular connectivity available, to provide patients with seamless connectivity to their ...
(Date:4/23/2020)... (PRWEB) , ... April 22, 2020 , ... ... equipment for healthcare providers to protect themselves from COVID-19. Virginia has only been ... the Federal Emergency Management Association (FEMA). , As Governor Northam told the Virginia ...
Breaking Biology Technology:
Cached News: