HOME >> BIOLOGY >> NEWS
Discovery in plants suggests entirely new approach to treating human cancers

BLOOMINGTON, Ind. -- For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone -- auxin -- interacts with its hormone receptor, called TIR1. Their report, on the cover of this week's issue of Nature, also may have important implications for the treatment of human disease, because TIR1 is similar to human enzymes that are known to be involved in cancer.

"Learning that auxin regulates TIR1 is a huge advance for plant biology that will probably have important implications for agriculture in the future," said IU Bloomington plant biologist Mark Estelle. "It's a bonus for us that TIR1 is related to proteins in other organisms, including humans. Some of TIR1's human relatives play a role in different human cancers, and it is possible that our work on plants will eventually lead to new cancer drugs."

Until now it was believed enzymes like TIR1, called ubiquitin ligases, could only be controlled through protein-protein interactions. Ubiquitin ligases influence growth and light response in plants, poison mitigation in yeasts and also cancerous cell division in humans.

"Although ubiquitin ligases have long been recognized as potential drug targets for treating cancers and other human diseases, it's been a bumpy road for scientists to come up with a feasible approach," said University of Washington School of Medicine pharmacologist Ning Zheng, who led the research. "The mechanism by which auxin works points out a new direction for us to develop therapeutic compounds targeting ubiquitin ligases."

The scientists extracted and purified TIR1 from the common plant model Arabidopsis. By x-raying crystals of the protein, Zheng, Estelle and colleagues determined the enzyme's three-dimensional structure -- a first for plant hormone receptors. The scientists then soaked the crystal in a solution containing auxin and
'"/>

Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
4-Apr-2007


Page: 1 2

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery could help bring down price of DNA sequencing
4. Discovery in orange cauliflower may lead to more nutritious crops
5. Discovery of new family of pseudo-metallic chemicals
6. Discovery of master switch for the communication process between chloroplast and nuclei of plants
7. Discovery of new cave millipedes casts light on Arizona cave ecology
8. Discovery of chemical profiles for infectious diarrhea
9. Discovery could lead to better control of hemorrhagic fever viruses
10. Honey bee researcher wins National Research Initiative Discovery Award
11. Faculty of 1,000 biology launch Pharmacology & Drug Discovery Faculty

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... SOMERSET, N.J. (PRWEB) , ... August 25, 2020 ... ... technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and ... the upcoming 16th Annual PEGS Boston Virtual Conference & Expo, taking place between ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... and expo uniting life science, data science, informatics and IT leaders goes VIRTUAL ... this period of uncertainty and change, Bio-IT takes the leadership role of keeping ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... the prestigious National STEM Scholar Program, a unique professional development program that provides ... support for middle school science teachers nationwide. , Created in partnership between the ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... TORONTO (PRWEB) , ... July 29, 2020 , ... eSource ... and inefficiencies. This webinar will cover the history of eSource, the reasons it did ... From EMR/EHR to wearables, to site source, the industry is moving towards capturing data ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and ...
Breaking Biology Technology:
Cached News: