HOME >> BIOLOGY >> NEWS
Discovery of a molecular mechanism underlying limb architecture

Montreal, October 24, 2006 A genetic study performed by Dr. Marie Kmita, a researcher at the Institut de Recherches Cliniques de Montral (IRCM), in collaboration with Drs Basile Tarchini and Denis Duboule of the University of Geneva in Switzerland, sheds light on the origins of the architecture of arms and legs. The results of their research, to be published in the October 26 issue of the prestigious journal Nature, describe how the operational mode of several "architect" genes has been recycled in the course of evolution to enable limb formation.

The establishment of the body architecture is genetically controlled and involves a family of "architect" genes called the Hox genes which has been conserved throughout evolution. The ancestral function of the Hox genes is to set up "foundations" of the body by defining positional information that instruct cells about their fate. This is how the body is shaped and how organs and skeletal elements are positioned. In the course of evolution, some of these genes have been reused to control limb development. Indeed, previous research by Dr. Kmita showed that without these genes, limbs would not form.

The particular feature of Hox genes is that they are aligned along the DNA molecule in the same order as the structures they will form. The sequential activation of these genes is therefore responsible for the defined distribution of organs and various parts of the skeleton along the anterior-posterior axis (from the head to the feet). The study, carried out by Dr. Kmita and her colleagues, shows that the ancestral strategy underlying Hox genes' activation was recycled during the emergence of vertebrate limbs to set up the architecture of arms and legs. In embryonic limb buds, the Hox genes are sequentially activated so that their domains of activity overlap along the anterior-posterior axis (from the thumb to the little finger), with a maximum activity in the posterior domain. It is precisely this peak of a
'"/>

Contact: Lucette Thriault
lucette.theriault@ircm.qc.ca
514-987-5535
Institut de recherches cliniques de Montreal
25-Oct-2006


Page: 1 2

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery could help bring down price of DNA sequencing
4. Discovery in orange cauliflower may lead to more nutritious crops
5. Discovery of new family of pseudo-metallic chemicals
6. Discovery in plants suggests entirely new approach to treating human cancers
7. Discovery of master switch for the communication process between chloroplast and nuclei of plants
8. Discovery of new cave millipedes casts light on Arizona cave ecology
9. Discovery of chemical profiles for infectious diarrhea
10. Discovery could lead to better control of hemorrhagic fever viruses
11. Honey bee researcher wins National Research Initiative Discovery Award

Post Your Comments:
(Date:7/30/2014)... of the Entomological Society of America (ESA) has elected ... election as a Fellow acknowledges outstanding contributions to entomology ... extension, or administration. The following Fellows will be recognized ... which will be held November 16-19, 2014 in Portland, ... a professor with the Department of Plant, Soil and ...
(Date:7/30/2014)... Laboratory has received a pledge of $1 million from ... the Laboratory,s new Neurobehavioral Biometry Center. , ... will enable the Laboratory to develop a greater breadth ... ultimate goal of accelerating the pace of research to ... as a premier resource for the Laboratory and its ...
(Date:7/30/2014)... a changing climate threaten some of the world,s ... conservationists establish seed collections to save the seeds ... preserving some genetic diversity., For decades, these seed ... offer a one-size-fits-all approach for how many seeds ... samples regardless of species, pollination mode, growth habitat ...
Breaking Biology News(10 mins):Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Saving seeds the right way can save the world's plants 2
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
(Date:7/30/2014)... MD (PRWEB) July 30, 2014 ... today the release of the REVELERIS® Prep ... organic chemists, preparative chromatographers, and other researchers to ... using a single unit. , With the REVELERIS® ... flash and preparative chromatography modes with a simple ...
(Date:7/30/2014)... July 30, 2014  Replikins Ltd. today released new ... Ebola virus. Before the current outbreaks, the mean Ebola ... amino acids) between 1995 and 2002 was 1.1; the ... 2012, and sixteen-fold in 2013, thus predicting the current ... technology has been shown to be able to predict ...
(Date:7/30/2014)... 2014   Wyle has been named ... Mission Support Services (FILMSS) contract awarded by the ... terms of the contract, Wyle will provide mission ... Calif. In particular, Wyle will provide program and ... on the International Space Station and collaborative science ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Grace Launches New REVELERIS® Prep Purification System 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2
Cached News: