HOME >> BIOLOGY >> NEWS
Discovery of a molecular mechanism underlying limb architecture

Montreal, October 24, 2006 A genetic study performed by Dr. Marie Kmita, a researcher at the Institut de Recherches Cliniques de Montral (IRCM), in collaboration with Drs Basile Tarchini and Denis Duboule of the University of Geneva in Switzerland, sheds light on the origins of the architecture of arms and legs. The results of their research, to be published in the October 26 issue of the prestigious journal Nature, describe how the operational mode of several "architect" genes has been recycled in the course of evolution to enable limb formation.

The establishment of the body architecture is genetically controlled and involves a family of "architect" genes called the Hox genes which has been conserved throughout evolution. The ancestral function of the Hox genes is to set up "foundations" of the body by defining positional information that instruct cells about their fate. This is how the body is shaped and how organs and skeletal elements are positioned. In the course of evolution, some of these genes have been reused to control limb development. Indeed, previous research by Dr. Kmita showed that without these genes, limbs would not form.

The particular feature of Hox genes is that they are aligned along the DNA molecule in the same order as the structures they will form. The sequential activation of these genes is therefore responsible for the defined distribution of organs and various parts of the skeleton along the anterior-posterior axis (from the head to the feet). The study, carried out by Dr. Kmita and her colleagues, shows that the ancestral strategy underlying Hox genes' activation was recycled during the emergence of vertebrate limbs to set up the architecture of arms and legs. In embryonic limb buds, the Hox genes are sequentially activated so that their domains of activity overlap along the anterior-posterior axis (from the thumb to the little finger), with a maximum activity in the posterior domain. It is precisely this peak of a
'"/>

Contact: Lucette Thriault
lucette.theriault@ircm.qc.ca
514-987-5535
Institut de recherches cliniques de Montreal
25-Oct-2006


Page: 1 2

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery could help bring down price of DNA sequencing
4. Discovery in orange cauliflower may lead to more nutritious crops
5. Discovery of new family of pseudo-metallic chemicals
6. Discovery in plants suggests entirely new approach to treating human cancers
7. Discovery of master switch for the communication process between chloroplast and nuclei of plants
8. Discovery of new cave millipedes casts light on Arizona cave ecology
9. Discovery of chemical profiles for infectious diarrhea
10. Discovery could lead to better control of hemorrhagic fever viruses
11. Honey bee researcher wins National Research Initiative Discovery Award

Post Your Comments:
(Date:10/14/2014)... fly genome for the first time, revealing robust immune ... thrives in pathogen-rich dung piles and garbage heaps. , ... Genome Biology , will increase understanding of house fly ... to resist insecticides, which could lead to novel control ... transmit more than 100 human and animal diseases, including ...
(Date:10/14/2014)... Sinai-led research team has discovered a new kind of stem ... cell that lines liver blood vessels, according to a study ... The existence of such a cell type contradicts current theory ... and may hold clues to origins of, and future treatment ... a single cell into a complex being made up of ...
(Date:10/14/2014)... – Scientists from The Scripps Research Institute (TSRI) have ... Health (NIH) to lead an investigation of Lassa fever ... Africa. The study aims to understand how Lassa fever ... others survive the inflection. , "The ultimate goal ... how Lassa fever virus causes disease and develop new ...
Breaking Biology News(10 mins):House fly genome reveals expanded immune system 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
(Date:10/19/2014)... The Latin American hardware encryption display market report defines ... and forecast of revenue. This market was valued at ... $2,366.8 million by 2018, at a CAGR of 70.3% ... of the Latin American hardware encryption market report to ... also provides a glimpse of the segmentation of the ...
(Date:10/19/2014)... Asian Automatic patient billing report defines and segments the ... The Automatic patient billing market in Asia is estimated ... a developing CAGR of 7.2% from 2013 to 2018. ... patient billing market, to get an idea of the ... the segmentation of this market in the same region, ...
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by Application ... & by Geography - Forecasts & Analysis 2014–2020", ... market into various sub segments with an in-depth ... also identifies the factors driving this market, various ... adoption trends. , The unmanned ground vehicle market ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The ... - Trends and Forecasts to 2019", analyzes the ... in order to understand the industry details such ... opportunities across various geographic regions. , Browse 81 ... 202 Slides and in-depth TOC on “1,6-Hexanediol Market ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 51,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
Cached News: