HOME >> BIOLOGY >> NEWS
Discovery of new protein could provide new understanding of male fertility

Bethesda, Md. Scientists have discovered a new enzyme involved in the degradation of proteins inside cells, a process that helps eliminate or recycle proteins that are no longer needed. The unexpected discovery, made by Marcus Groettrup, chair of the immunology department at the University of Constance, Konstanz, Germany, and colleagues, overthrows the idea that protein degradation is initiated by only one enzyme. Also, the new enzyme is very highly expressed in the testis, which could provide a new understanding of male fertility.

We essentially found that cleanup in the cell is not supervised by one but by two proteins, Groettrup says. It is important because everything we know about this cleanup process assumes that only one enzyme initiates it. The second protein we discovered may either share some functions with the first one or do totally different things.

The new study, to be published in the August 3 issue of the Journal of Biological Chemistry, was selected as a Paper of the Week by the journals editors, meaning that it belongs to the top one percent of papers reviewed in significance and overall importance.

Before being degraded, proteins are tagged with a small protein called ubiquitin. Three types of enzymes are involved in the tagging process. An enzyme called activating enzyme E1 first activates ubiquitin and binds to it. Then the ubiquitin is transferred to a second enzyme called ubiquitin-conjugating enzyme E2. And a third enzyme, called ubiquitin ligase E3 binds to both E2 and the protein to be degraded, so that E2 can transfer the ubiquitin to the protein. By binding to other ubiquitin-carrying E2 enzymes, E3 transfers many ubiquitins to the protein, signaling to the cell that the protein needs to be degraded.

Until now, only one type of E1 enzyme for ubiquitin has been known to exist in the human genome, while 34 E2 enzymes and 531 E3 enzymes have been discovered. Bec
'"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
2-Aug-2007


Page: 1 2 3

Related biology news :

1. Discovery in plant virus may help prevent HIV and similar viruses
2. Discovery could help bring down price of DNA sequencing
3. Discovery in orange cauliflower may lead to more nutritious crops
4. Discovery of new family of pseudo-metallic chemicals
5. Discovery in plants suggests entirely new approach to treating human cancers
6. Discovery of master switch for the communication process between chloroplast and nuclei of plants
7. Discovery of new cave millipedes casts light on Arizona cave ecology
8. Discovery of chemical profiles for infectious diarrhea
9. Discovery could lead to better control of hemorrhagic fever viruses
10. Honey bee researcher wins National Research Initiative Discovery Award
11. Faculty of 1,000 biology launch Pharmacology & Drug Discovery Faculty

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: