HOME >> BIOLOGY >> NEWS
Discovery offers cancer prevention, diagnosis, treatment hopes

EAST LANSING, Mich. Michigan State University researchers have found that a certain gene, expressed within a human adult stem cell, could hold the key to not only offering new hope to cancer patients, but also to answering the question of how cancer originates.

The discovery that the gene known as oct-4 is expressed in normal adult stem cells, by MSU's James Trosko and colleagues, is detailed in the February issue of Carcinogenesis, one of the world's top cancer-research journals.

It was already known that the oct-4 gene was located in embryonic stem cells as well as tumor cells, but researchers were uncertain whether it was expressed in adult stem cells.

The MSU researchers, using methods pioneered in their laboratory, were able to test adult stem cells for the expression of the oct-4 gene and found that it was expressed in some adult stem cells.

"If oct-4 is a biomarker for adult stem cells that gives rise to cancer cells," Trosko said, "then learning how to turn off the expression of the oct-4 gene in cancer cells or even in pre-malignant cells should have tremendous implications for both prevention and treatment of cancer."

In particular, he said, the use of oct-4 as a screening marker to identify new chemoprevention dietary agents and chemotherapeutic drugs could be extremely helpful in fighting cancer.

"This is especially significant in light of recent findings that, within the billions of cells of a tumor, there exists a few 'cancer stem cells' that seem to be the cells that are resistant to cancer therapy," Trosko said. "In other words, current practices to treat cancers have been directed at the wrong tumor cells."

The oct-4 gene is a "regulatory" gene, one whose job is to control the expression of other genes.

When it comes to the question of where cancer cells originate, there are two prevailing theories: Either a single stem cell is the target for the process to begin, or any highly spec
'"/>

Contact: Tom Oswald
oswald@msu.edu
517-432-0920
Michigan State University
17-Feb-2005


Page: 1 2

Related biology news :

1. Discovery of new protein could provide new understanding of male fertility
2. Discovery in plant virus may help prevent HIV and similar viruses
3. Discovery could help bring down price of DNA sequencing
4. Discovery in orange cauliflower may lead to more nutritious crops
5. Discovery of new family of pseudo-metallic chemicals
6. Discovery in plants suggests entirely new approach to treating human cancers
7. Discovery of master switch for the communication process between chloroplast and nuclei of plants
8. Discovery of new cave millipedes casts light on Arizona cave ecology
9. Discovery of chemical profiles for infectious diarrhea
10. Discovery could lead to better control of hemorrhagic fever viruses
11. Honey bee researcher wins National Research Initiative Discovery Award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... June 25, 2019 , ... ... Using 23andMe raw data, easily available from 23andMe, customers can get access to ... service is available for both 23andMe Ancestry and Health + Ancestry customers., With ...
(Date:6/16/2019)... , ... June 14, 2019 , ... ... invited to lecture at the fifth annual Neodent World Congress. Attended by thousands ... innovative progress and latest advancements in the world of dentistry. The three-day event ...
(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly growing ... leverage the Geneious Biologics platform as a premium hub for bioinformatics and computer ... says: “The Geneious team has done an excellent job accommodating our specific data, ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... June ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... partnership agreement with Shanghai Zillion has been signed. The agreement will grant exclusive ...
(Date:6/11/2019)... CITY, Calif. (PRWEB) , ... June 10, 2019 ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to DeepDyve’s ... of physics-related content to DeepDyve’s continually expanding library of more than 20 million ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
(Date:5/31/2019)... (PRWEB) , ... May 29, ... ... our patent applications from the USPTO providing proprietary interest to our methodology, ... FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our ...
Breaking Biology Technology:
Cached News: