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Doctors link common chemotherapy drug to jawbone necrosis

s, osteoblasts -- "the good guys"-- put calcium in the matrix of the bone and make bone stronger, and osteoclasts -- "the bad guys" -- take calcium away, diminishing the internal strength of the bone. Bone remodeling is like a necessary game of tug-of-war between the goods guys and the bad. Bone mass and mineral content constantly adjust throughout the life cycle to support the places on the skeleton where the most outside force occurs.

Novartis's Aredia (pamidronate disodium) and Zometa (zoledronic acid) injections are the two intravenous bisphophosphonates used in chemotherapy regimens. Novartis changed their labeling in August. Merck's Fosamax (alendronate) and Procter and Gamble Pharmaceuticals's Actonel (risedronate sodium) are the most commonly used oral bisphosphonates, which are only indicated for osteoporosis. Labeling for the oral forms has not been changed. "The oral form is much less potent than the intravenous form and appears to be substantially less likely to cause the problem," said Dr. Ruggiero.


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Contact: Christina Verni
cverni@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
13-Dec-2004


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